Open Access
Open access
Science advances, volume 9, issue 43

Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17

Yalong Wang 1, 2, 3
Ruoyu Lou 1
Zhe Zhang 3, 4
Chuyu Xiao 1
Shicheng Yu 2, 3
Siting Wei 1
Yuan Liu 1
Wei Fu 5
Bao-Jie Li 6
Ye-Guang Chen 1, 3, 7
Show full list: 10 authors
Publication typeJournal Article
Publication date2023-10-27
Journal: Science advances
scimago Q1
SJR4.483
CiteScore21.4
Impact factor11.7
ISSN23752548
Multidisciplinary
Abstract

Bone morphogenic protein (BMP) signaling is critical for intestinal development, homeostasis, and function performance. Although the function of BMP signaling in the intestinal epithelium is well appreciated, the direct effect of BMP on intestinal stromal cells is poorly understood. Here, we show that disruption of BMP signaling by genetic ablation of Alk3 or Smad4 expands the stromal cell pool, the mucosa tumefaction, and colonic polyposis in the large intestine. Interleukin (IL) secretion by stromal cells is notably increased, including IL-1, IL-11, and IL-17. Specifically, IL-1 and IL-17a hyperactivate the mucin production by goblet cells through nuclear factor κB signaling, and abnormal mucin accumulation results in the morphological changes, epithelial barrier destruction, and polyposis development. Together, our results provide an insight into the role of BMP signaling in intestinal stromal cells to regulate epithelium function. This study further highlights the role of mucin-producing goblet cells in intestinal homeostasis and colitis development.

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