Open Access
DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway
Publication type: Journal Article
Publication date: 2015-10-30
scimago Q1
wos Q1
SJR: 10.416
CiteScore: 48.4
Impact factor: 45.8
ISSN: 00368075, 10959203
PubMed ID:
26405230
Multidisciplinary
Abstract
Viral oncogenes remove the host's STING
Cancer-causing viruses, such as the human papilloma virus (HPV) that causes cervical cancer, account for 12% of human cancers. One way they can cause cancer is by targeting tumor suppressor proteins in the host. Now Lau et al. report that DNA tumor viruses can also thwart the host's immune system. Oncogenes from HPV and human adenovirus bound to the protein STING, a key component of the cGAS-STING pathway that senses and defends against intracellular DNA. In this way, the viruses subvert the host's antiviral immunity and set up shop, which, for an unlucky few, eventually causes cancer.
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Metrics
400
Total citations:
400
Citations from 2024:
72
(18.09%)
Cite this
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MLA
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GOST
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Lau L. et al. DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway // Science. 2015. Vol. 350. No. 6260. pp. 568-571.
GOST all authors (up to 50)
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Lau L., Gray E. E., Brunette R. L., Stetson D. B. DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway // Science. 2015. Vol. 350. No. 6260. pp. 568-571.
Cite this
RIS
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TY - JOUR
DO - 10.1126/science.aab3291
UR - https://doi.org/10.1126/science.aab3291
TI - DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway
T2 - Science
AU - Lau, Laura
AU - Gray, Elizabeth E.
AU - Brunette, Rebecca L
AU - Stetson, Daniel B.
PY - 2015
DA - 2015/10/30
PB - American Association for the Advancement of Science (AAAS)
SP - 568-571
IS - 6260
VL - 350
PMID - 26405230
SN - 0036-8075
SN - 1095-9203
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2015_Lau,
author = {Laura Lau and Elizabeth E. Gray and Rebecca L Brunette and Daniel B. Stetson},
title = {DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway},
journal = {Science},
year = {2015},
volume = {350},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {oct},
url = {https://doi.org/10.1126/science.aab3291},
number = {6260},
pages = {568--571},
doi = {10.1126/science.aab3291}
}
Cite this
MLA
Copy
Lau, Laura, et al. “DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway.” Science, vol. 350, no. 6260, Oct. 2015, pp. 568-571. https://doi.org/10.1126/science.aab3291.