Open Access
Microglia development follows a stepwise program to regulate brain homeostasis
Orit Matcovitch Natan
1, 2
,
Deborah R Winter
1
,
Amir Giladi
1
,
Stephanie Vargas Aguilar
3, 4, 5, 6
,
Amit Spinrad
1, 2
,
Sandrine Sarrazin
3, 4, 5
,
Hila Ben-Yehuda
2
,
Eyal David
1
,
Fabiola Zelada González
3, 4, 5
,
Pierre Perrin
3, 4, 5
,
Hadas Keren Shaul
1
,
Meital Gury
1
,
David Lara Astaiso
1
,
Christoph A. Thaiss
1
,
Merav Cohen
2
,
Keren Bahar Halpern
7
,
Kuti Baruch
2
,
Aleksandra Deczkowska
2
,
Erika Lorenzo Vivas
1
,
SHALEV ITZKOVITZ
7
,
Eran Elinav
1
,
Michael H Sieweke
3, 4, 5, 6
,
Michal Schwartz
2
,
Ido Amit
1
5
Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France.
|
6
Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC), Robert-Rössle-Straß 10, 13125 Berlin, Germany.
|
Publication type: Journal Article
Publication date: 2016-08-19
scimago Q1
wos Q1
SJR: 10.416
CiteScore: 48.4
Impact factor: 45.8
ISSN: 00368075, 10959203
PubMed ID:
27338705
Multidisciplinary
Abstract
Microglia development follows a stepwise program
Microglia are cells that defend the central nervous system. However, because they migrate into the brain during development, the changes that they undergo, including those that affect gene expression, have been difficult to document. Matcovitch-Natan et al. transcriptionally profiled gene expression and analyzed epigenetic signatures of microglia at the single-cell level in the early postnatal life of mice. They identified three stages of microglia development, which are characterized by gene expression and linked with chromatin changes, occurring in sync with the developing brain. Furthermore, they showed that the proper development of microglia is affected by the microbiome.
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GOST
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Matcovitch Natan O. et al. Microglia development follows a stepwise program to regulate brain homeostasis // Science. 2016. Vol. 353. No. 6301.
GOST all authors (up to 50)
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Matcovitch Natan O., Winter D. R., Giladi A., Vargas Aguilar S., Spinrad A., Sarrazin S., Ben-Yehuda H., David E., Zelada González F., Perrin P., Keren Shaul H., Gury M., Lara Astaiso D., Thaiss C. A., Cohen M., Bahar Halpern K., Baruch K., Deczkowska A., Lorenzo Vivas E., ITZKOVITZ S., Elinav E., Sieweke M. H., Schwartz M., Amit I. Microglia development follows a stepwise program to regulate brain homeostasis // Science. 2016. Vol. 353. No. 6301.
Cite this
RIS
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TY - JOUR
DO - 10.1126/science.aad8670
UR - https://doi.org/10.1126/science.aad8670
TI - Microglia development follows a stepwise program to regulate brain homeostasis
T2 - Science
AU - Matcovitch Natan, Orit
AU - Winter, Deborah R
AU - Giladi, Amir
AU - Vargas Aguilar, Stephanie
AU - Spinrad, Amit
AU - Sarrazin, Sandrine
AU - Ben-Yehuda, Hila
AU - David, Eyal
AU - Zelada González, Fabiola
AU - Perrin, Pierre
AU - Keren Shaul, Hadas
AU - Gury, Meital
AU - Lara Astaiso, David
AU - Thaiss, Christoph A.
AU - Cohen, Merav
AU - Bahar Halpern, Keren
AU - Baruch, Kuti
AU - Deczkowska, Aleksandra
AU - Lorenzo Vivas, Erika
AU - ITZKOVITZ, SHALEV
AU - Elinav, Eran
AU - Sieweke, Michael H
AU - Schwartz, Michal
AU - Amit, Ido
PY - 2016
DA - 2016/08/19
PB - American Association for the Advancement of Science (AAAS)
IS - 6301
VL - 353
PMID - 27338705
SN - 0036-8075
SN - 1095-9203
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2016_Matcovitch Natan,
author = {Orit Matcovitch Natan and Deborah R Winter and Amir Giladi and Stephanie Vargas Aguilar and Amit Spinrad and Sandrine Sarrazin and Hila Ben-Yehuda and Eyal David and Fabiola Zelada González and Pierre Perrin and Hadas Keren Shaul and Meital Gury and David Lara Astaiso and Christoph A. Thaiss and Merav Cohen and Keren Bahar Halpern and Kuti Baruch and Aleksandra Deczkowska and Erika Lorenzo Vivas and SHALEV ITZKOVITZ and Eran Elinav and Michael H Sieweke and Michal Schwartz and Ido Amit},
title = {Microglia development follows a stepwise program to regulate brain homeostasis},
journal = {Science},
year = {2016},
volume = {353},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {aug},
url = {https://doi.org/10.1126/science.aad8670},
number = {6301},
doi = {10.1126/science.aad8670}
}