Open Access

Science

, volume 359 , issue 6374 , pages 424-428

The nature of nurture: Effects of parental genotypes

Augustine Kong ^{1, 2, 3}

Gudmar Thorleifsson ¹

Michael L. Frigge ¹

Bjarni Jóhann Vilhjálmsson ^{4, 5}

Alexander I Young ^{1, 2, 6}

Thorgeir E. Thorgeirsson ¹

Benonisdottir S ¹

Ásmundur Oddsson ¹

Bjarni V. Halldorsson ¹

Gisli Masson ¹

Daniel Gudbjartsson ^{1, 3}

A. Helgason ^{1, 7}

Bjornsdottir G ¹

Unnur Thorsteinsdottir ^{1, 8}

Kari Stefansson ^{1, 8}

Hide authors affiliations Show authors affiliations: 8 affiliations

deCODE genetics/Amgen, 101 Reykjavik, Iceland. |

Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, UK. |

School of Engineering and Natural Sciences, University of Iceland, 101 Reykjavik, Iceland. |

⁴

Bioinformatics Research Centre, Aarhus University, 8000 Aarhus, Denmark. |

⁵

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. |

⁶

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK. |

⁷

Department of Anthropology, University of Iceland, 101 Reykjavik, Iceland. |

⁸

Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland. |

Publication type: Journal Article

Publication date: 2018-01-26

American Association for the Advancement of Science (AAAS)

Science

scimago Q1

wos Q1

SJR: 10.416

CiteScore: 48.4

Impact factor: 45.8

ISSN: 00368075, 10959203

DOI: 10.1126/science.aan6877

Copy DOI

PubMed ID: 29371463

Multidisciplinary

Abstract

Genetic variants provide a nurturing environment

Genetic variants in parents may affect the fitness of their offspring, even if the child does not carry the allele. This indirect effect is referred to as “genetic nurture.” Kong et al. used data from genome-wide association studies of educational attainment to construct polygenic scores for parents that only considered the nontransmitted alleles (see the Perspective by Koellinger and Harden). The findings suggest that genetic nurture is ultimately due to genetic variation in the population and is mediated by the environment that parents create for their children.

Science , this issue p. 424 ; see also p. 386

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Kong A. et al. The nature of nurture: Effects of parental genotypes // Science. 2018. Vol. 359. No. 6374. pp. 424-428.

GOST all authors (up to 50) Copy

Kong A., Thorleifsson G., Frigge M. L., Vilhjálmsson B. J., Young A. I., Thorgeirsson T. E., S B., Oddsson Á., Halldorsson B. V., Masson G., Gudbjartsson D., Helgason A., G B., Thorsteinsdottir U., Stefansson K. The nature of nurture: Effects of parental genotypes // Science. 2018. Vol. 359. No. 6374. pp. 424-428.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1126/science.aan6877

UR - https://doi.org/10.1126/science.aan6877

TI - The nature of nurture: Effects of parental genotypes

T2 - Science

AU - Kong, Augustine

AU - Thorleifsson, Gudmar

AU - Frigge, Michael L.

AU - Vilhjálmsson, Bjarni Jóhann

AU - Young, Alexander I

AU - Thorgeirsson, Thorgeir E.

AU - S, Benonisdottir

AU - Oddsson, Ásmundur

AU - Halldorsson, Bjarni V.

AU - Masson, Gisli

AU - Gudbjartsson, Daniel

AU - Helgason, A.

AU - G, Bjornsdottir

AU - Thorsteinsdottir, Unnur

AU - Stefansson, Kari

PY - 2018

DA - 2018/01/26

PB - American Association for the Advancement of Science (AAAS)

SP - 424-428

IS - 6374

VL - 359

PMID - 29371463

SN - 0036-8075

SN - 1095-9203

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2018_Kong,

author = {Augustine Kong and Gudmar Thorleifsson and Michael L. Frigge and Bjarni Jóhann Vilhjálmsson and Alexander I Young and Thorgeir E. Thorgeirsson and Benonisdottir S and Ásmundur Oddsson and Bjarni V. Halldorsson and Gisli Masson and Daniel Gudbjartsson and A. Helgason and Bjornsdottir G and Unnur Thorsteinsdottir and Kari Stefansson},

title = {The nature of nurture: Effects of parental genotypes},

journal = {Science},

year = {2018},

volume = {359},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {jan},

url = {https://doi.org/10.1126/science.aan6877},

number = {6374},

pages = {424--428},

doi = {10.1126/science.aan6877}

}

MLA

Cite this

MLA Copy

Kong, Augustine, et al. “The nature of nurture: Effects of parental genotypes.” Science, vol. 359, no. 6374, Jan. 2018, pp. 424-428. https://doi.org/10.1126/science.aan6877.

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science

scimago Q1

wos Q1

SJR

10.416

CiteScore

48.4

Impact factor

45.8

ISSN

00368075 (Print)

10959203 (Electronic)