Open Access
Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells
Bogdan Bintu
1
,
Leslie J Mateo
2
,
Jun Han Su
1
,
Nicholas A Sinnott Armstrong
3
,
Mirae Parker
4
,
Seon Kinrot
1
,
Kei Yamaya
2
,
Alistair Boettiger
2
,
Xiaowei Zhuang
1
1
Publication type: Journal Article
Publication date: 2018-10-26
scimago Q1
wos Q1
SJR: 10.416
CiteScore: 48.4
Impact factor: 45.8
ISSN: 00368075, 10959203
PubMed ID:
30361340
Multidisciplinary
Abstract
Imaging chromatin spatial organization
The genome is organized within the nucleus as three-dimensional domains that modulate DNA-templated processes. Bintu et al. used high-throughput Oligopaint labeling and imaging to observe chromatin dynamics inside the nuclei of several different mammalian cell lines. After combining the datasets, single-cell matrices revealed chromatin arranged in topologically associating domains (TADs). Removing cohesin resulted in a loss of aggregate TADs among populations of cells, but specific TADs were still detected at the single-cell level. Furthermore, higher-order organization was detected, suggestive of cooperative interactions within the genome.
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915
Total citations:
915
Citations from 2025:
135
(14.75%)
Cite this
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Bintu B. et al. Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells // Science. 2018. Vol. 362. No. 6413.
GOST all authors (up to 50)
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Bintu B., Mateo L. J., Su J. H., Sinnott Armstrong N. A., Parker M., Kinrot S., Yamaya K., Boettiger A., Zhuang X. Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells // Science. 2018. Vol. 362. No. 6413.
Cite this
RIS
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TY - JOUR
DO - 10.1126/science.aau1783
UR - https://doi.org/10.1126/science.aau1783
TI - Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells
T2 - Science
AU - Bintu, Bogdan
AU - Mateo, Leslie J
AU - Su, Jun Han
AU - Sinnott Armstrong, Nicholas A
AU - Parker, Mirae
AU - Kinrot, Seon
AU - Yamaya, Kei
AU - Boettiger, Alistair
AU - Zhuang, Xiaowei
PY - 2018
DA - 2018/10/26
PB - American Association for the Advancement of Science (AAAS)
IS - 6413
VL - 362
PMID - 30361340
SN - 0036-8075
SN - 1095-9203
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Bintu,
author = {Bogdan Bintu and Leslie J Mateo and Jun Han Su and Nicholas A Sinnott Armstrong and Mirae Parker and Seon Kinrot and Kei Yamaya and Alistair Boettiger and Xiaowei Zhuang},
title = {Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells},
journal = {Science},
year = {2018},
volume = {362},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {oct},
url = {https://doi.org/10.1126/science.aau1783},
number = {6413},
doi = {10.1126/science.aau1783}
}