Open Access
Systematic discovery of natural CRISPR-Cas12a inhibitors
Тип публикации: Journal Article
Дата публикации: 2018-10-12
SCImago Q1
Tоп 10% SCImago
WOS Q1
БС1
SJR: 10.948
CiteScore: 44.6
Impact factor: 47.3
ISSN: 00368075, 10959203
PubMed ID:
30190307
Multidisciplinary
Краткое описание
Cas12 inhibitors join the anti-CRISPR family
Bacteria and their phages continually coevolve in a molecular arms race. For example, phages use anti-CRISPR proteins to inhibit the bacterial type I and II CRISPR systems (see the Perspective by Koonin and Makarova). Watters et al. and Marino et al. used bioinformatic and experimental approaches to identify inhibitors of type V CRISPR-Cas12a. Cas12a has been successfully engineered for gene editing and nucleic acid detection. Some of the anti-Cas12a proteins identified in these studies had broad-spectrum inhibitory effects on Cas12a orthologs and could block Cas12a-mediated genome editing in human cells.
Science
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Метрики
191
Всего цитирований:
191
Цитирований c 2025:
11
(5.76%)
Цитировать
ГОСТ |
RIS |
BibTex |
MLA
Цитировать
ГОСТ
Скопировать
Watters K. et al. Systematic discovery of natural CRISPR-Cas12a inhibitors // Science. 2018. Vol. 362. No. 6411. pp. 236-239.
ГОСТ со всеми авторами (до 50)
Скопировать
Watters K., Fellmann C., Bai H. B., Ren S. M., Doudna J. A. Systematic discovery of natural CRISPR-Cas12a inhibitors // Science. 2018. Vol. 362. No. 6411. pp. 236-239.
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RIS
Скопировать
TY - JOUR
DO - 10.1126/science.aau5138
UR - https://doi.org/10.1126/science.aau5138
TI - Systematic discovery of natural CRISPR-Cas12a inhibitors
T2 - Science
AU - Watters, Kyle
AU - Fellmann, Christof
AU - Bai, Hua B
AU - Ren, Shawn M
AU - Doudna, Jennifer A.
PY - 2018
DA - 2018/10/12
PB - American Association for the Advancement of Science (AAAS)
SP - 236-239
IS - 6411
VL - 362
PMID - 30190307
SN - 0036-8075
SN - 1095-9203
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2018_Watters,
author = {Kyle Watters and Christof Fellmann and Hua B Bai and Shawn M Ren and Jennifer A. Doudna},
title = {Systematic discovery of natural CRISPR-Cas12a inhibitors},
journal = {Science},
year = {2018},
volume = {362},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {oct},
url = {https://doi.org/10.1126/science.aau5138},
number = {6411},
pages = {236--239},
doi = {10.1126/science.aau5138}
}
Цитировать
MLA
Скопировать
Watters, Kyle, et al. “Systematic discovery of natural CRISPR-Cas12a inhibitors.” Science, vol. 362, no. 6411, Oct. 2018, pp. 236-239. https://doi.org/10.1126/science.aau5138.
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