Open Access
Choline acetyltransferase–expressing T cells are required to control chronic viral infection
M A Cox
1
,
Gordon S Duncan
1
,
Gloria H. Y. Lin
1
,
Benjamin E. Steinberg
1, 2
,
Lisa X. Yu
3
,
Dirk Brenner
1, 4, 5
,
Luke N Buckler
1
,
Andrew E. H. Elia
1
,
Andrew C Wakeham
1
,
Brian Nieman
3, 6
,
Carmen Dominguez Brauer
1
,
ALISHA R. ELFORD
1
,
Kyle T Gill
1
,
Shawn P. Kubli
1
,
Jillian Haight
1
,
Thorsten Berger
1
,
Pamela S. Ohashi
1, 7
,
KEVIN TRACEY
8
,
Peder S Olofsson
8, 9
,
Tak W. Mak
1, 6, 7, 10
5
6
9
Publication type: Journal Article
Publication date: 2019-02-08
scimago Q1
wos Q1
SJR: 10.416
CiteScore: 48.4
Impact factor: 45.8
ISSN: 00368075, 10959203
PubMed ID:
30733420
Multidisciplinary
Abstract
ChAT-ty T cells fight viral infection
The neurotransmitter acetylcholine (ACh) is involved in processes such as muscle contraction, neuron communication, and vasodilation. Along with neurons, a population of immunological T cells and B cells express the enzyme choline acetyltransferase (ChAT), which catalyzes the rate-limiting step of ACh production. However, the role of immune cell–derived ACh is unclear. Cox et al. report that the cytokine interleukin-21 (IL-21) induces ChAT expression in CD4 + and CD8 + T cells during lymphocytic choriomeningitis virus infection (see the Perspective by Hickman). T cell–specific deletion of ChAT strongly impaired vasodilation and trafficking of antiviral T cells into infected tissues, which undermined the effective control of a chronic viral infection. Thus, IL-21 plays a critical role during chronic infection. Furthermore, the findings reveal a cholinergic mechanism that can regulate immune cell migration into tissues.
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Metrics
135
Total citations:
135
Citations from 2024:
53
(39.26%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Cox M. A. et al. Choline acetyltransferase–expressing T cells are required to control chronic viral infection // Science. 2019. Vol. 363. No. 6427. pp. 639-644.
GOST all authors (up to 50)
Copy
Cox M. A., Duncan G. S., Lin G. H. Y., Steinberg B. E., Yu L. X., Brenner D., Buckler L. N., Elia A. E. H., Wakeham A. C., Nieman B., Dominguez Brauer C., ELFORD A. R., Gill K. T., Kubli S. P., Haight J., Berger T., Ohashi P. S., TRACEY K., Olofsson P. S., Mak T. W. Choline acetyltransferase–expressing T cells are required to control chronic viral infection // Science. 2019. Vol. 363. No. 6427. pp. 639-644.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1126/science.aau9072
UR - https://doi.org/10.1126/science.aau9072
TI - Choline acetyltransferase–expressing T cells are required to control chronic viral infection
T2 - Science
AU - Cox, M A
AU - Duncan, Gordon S
AU - Lin, Gloria H. Y.
AU - Steinberg, Benjamin E.
AU - Yu, Lisa X.
AU - Brenner, Dirk
AU - Buckler, Luke N
AU - Elia, Andrew E. H.
AU - Wakeham, Andrew C
AU - Nieman, Brian
AU - Dominguez Brauer, Carmen
AU - ELFORD, ALISHA R.
AU - Gill, Kyle T
AU - Kubli, Shawn P.
AU - Haight, Jillian
AU - Berger, Thorsten
AU - Ohashi, Pamela S.
AU - TRACEY, KEVIN
AU - Olofsson, Peder S
AU - Mak, Tak W.
PY - 2019
DA - 2019/02/08
PB - American Association for the Advancement of Science (AAAS)
SP - 639-644
IS - 6427
VL - 363
PMID - 30733420
SN - 0036-8075
SN - 1095-9203
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Cox,
author = {M A Cox and Gordon S Duncan and Gloria H. Y. Lin and Benjamin E. Steinberg and Lisa X. Yu and Dirk Brenner and Luke N Buckler and Andrew E. H. Elia and Andrew C Wakeham and Brian Nieman and Carmen Dominguez Brauer and ALISHA R. ELFORD and Kyle T Gill and Shawn P. Kubli and Jillian Haight and Thorsten Berger and Pamela S. Ohashi and KEVIN TRACEY and Peder S Olofsson and Tak W. Mak},
title = {Choline acetyltransferase–expressing T cells are required to control chronic viral infection},
journal = {Science},
year = {2019},
volume = {363},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {feb},
url = {https://doi.org/10.1126/science.aau9072},
number = {6427},
pages = {639--644},
doi = {10.1126/science.aau9072}
}
Cite this
MLA
Copy
Cox, M. A., et al. “Choline acetyltransferase–expressing T cells are required to control chronic viral infection.” Science, vol. 363, no. 6427, Feb. 2019, pp. 639-644. https://doi.org/10.1126/science.aau9072.