Open Access
Lineage tracing on transcriptional landscapes links state to fate during differentiation
Publication type: Journal Article
Publication date: 2020-02-14
scimago Q1
wos Q1
SJR: 10.416
CiteScore: 48.4
Impact factor: 45.8
ISSN: 00368075, 10959203
PubMed ID:
31974159
Multidisciplinary
Abstract
Mapping cell fate during hematopoiesis
Biologists have long attempted to understand how stem and progenitor cells in regenerating and embryonic tissues differentiate into mature cell types. Through the use of recent technical advances to sequence the genes expressed in thousands of individual cells, differentiation mechanisms are being revealed. Weinreb et al. extended these methods to track clones of cells (cell families) across time. Their approach reveals differences in cellular gene expression as cells progress through hematopoiesis, which is the process of blood production. Using machine learning, they tested how well gene expression measurements account for the choices that cells make. This work reveals that a considerable gap still exists in understanding differentiation mechanisms, and future methods are needed to fully understand—and ultimately control—cell differentiation.
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Metrics
597
Total citations:
597
Citations from 2024:
225
(37.75%)
Cite this
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RIS |
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GOST
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Weinreb C. et al. Lineage tracing on transcriptional landscapes links state to fate during differentiation // Science. 2020. Vol. 367. No. 6479.
GOST all authors (up to 50)
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Weinreb C., Rodriguez-Fraticelli A. E., Camargo F. D., Klein A. M. Lineage tracing on transcriptional landscapes links state to fate during differentiation // Science. 2020. Vol. 367. No. 6479.
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RIS
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TY - JOUR
DO - 10.1126/science.aaw3381
UR - https://doi.org/10.1126/science.aaw3381
TI - Lineage tracing on transcriptional landscapes links state to fate during differentiation
T2 - Science
AU - Weinreb, Caleb
AU - Rodriguez-Fraticelli, Alejo E.
AU - Camargo, Fernando D.
AU - Klein, Allon M.
PY - 2020
DA - 2020/02/14
PB - American Association for the Advancement of Science (AAAS)
IS - 6479
VL - 367
PMID - 31974159
SN - 0036-8075
SN - 1095-9203
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Weinreb,
author = {Caleb Weinreb and Alejo E. Rodriguez-Fraticelli and Fernando D. Camargo and Allon M. Klein},
title = {Lineage tracing on transcriptional landscapes links state to fate during differentiation},
journal = {Science},
year = {2020},
volume = {367},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {feb},
url = {https://doi.org/10.1126/science.aaw3381},
number = {6479},
doi = {10.1126/science.aaw3381}
}