Open Access

Science

, volume 371 , issue 6527

Developmental cell programs are co-opted in inflammatory skin disease

Gary Reynolds ¹

Peter Vegh ¹

James Fletcher ¹

Elizabeth F M Poyner ^{1, 2}

Emily Stephenson ¹

Issac Goh ¹

Rachel Anne Botting ¹

Ni Huang ³

Bayanne Olabi ^{1, 4}

A Dubois ^{1, 2}

David Dixon ¹

Kile Green ¹

Daniel Maunder ¹

Justin Engelbert ¹

Mirjana Efremova ³

Krzysztof Polanski ³

Laura Jardine ¹

Claire J. Jones ¹

Thomas Ness ¹

Dave Horsfall ¹

Jim Mcgrath ¹

C. S. Carey ¹

Dorin Mirel Popescu ¹

Simone Webb ¹

Xiao-Nong Wang ¹

Ben Sayer ¹

Jong-Eun Park ³

Victor A Negri ⁵

Daria Belokhvostova ⁵

Magnus D. Lynch ⁵

David Mcdonald ¹

Andrew Filby ¹

Tzachi Hagai ⁶

Kerstin B. Meyer ³

A Husain ⁷

Jonathan Coxhead ¹

Roser Vento-Tormo ³

Sam Behjati ^{3, 8}

S. Lisgo ¹

Alexandra-Chloe Villani ^{9, 10}

Jaume Bacardit ¹¹

Philip H Jones ^{3, 12}

Edel A. O'Toole ¹³

Graham Ogg ¹⁴

Neil Rajan ^{1, 2}

N Reynolds ^{2, 15}

Sarah A. Teichmann ^{3, 16}

F. M. Watt ⁵

Muzlifah A. Haniffa ^{1, 2, 3}

Hide authors affiliations Show authors affiliations: 16 affiliations

Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. |

Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4LP, UK. |

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK. |

⁴

Department of Dermatology, NHS Lothian, Lauriston Building, Edinburgh EH3 9EN, UK. |

⁵

Centre for Stem Cells and Regenerative Medicine, King’s College London, Guy’s Hospital Campus, London SE1 9RT, UK. |

⁶

Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel. |

⁷

Department of Pathology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK. |

⁸

Department of Paediatrics, University of Cambridge, Cambridge CB2 0SP, UK. |

⁹

Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. |

¹⁰

Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02129, USA. |

¹¹

School of Computing, Newcastle University, Newcastle upon Tyne NE4 5TG, UK. |

¹²

MRC Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK. |

¹³

Centre for Cell Biology and Cutaneous Research, Blizard Institute, Queen Mary University of London, London, UK. |

¹⁴

MRC Human Immunology Unit, Oxford Biomedical Research Centre, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

University of Oxford

NIHR Oxford Musculoskeletal Biomedical Research Centre

¹⁵

Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. |

¹⁶

Theory of Condensed Matter Group, Cavendish Laboratory/Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK. |

Publication type: Journal Article

Publication date: 2021-01-22

American Association for the Advancement of Science (AAAS)

Science

scimago Q1

wos Q1

SJR: 10.416

CiteScore: 48.4

Impact factor: 45.8

ISSN: 00368075, 10959203

DOI: 10.1126/science.aba6500

Copy DOI

PubMed ID: 33479125

Multidisciplinary

Abstract

Cellular beauty is skin deep

Human skin works as barrier, preventing the entry of pathogens, among other functions. Reynolds et al. used single-cell sequencing to generate an atlas of the human skin from both developing and adult sources, identifying differences and similarities across heterogeneous populations of skin cells. In this atlas, gene expression in the two disease states studied—atopic dermatitis and psoriasis—varied from that in a healthy adult, suggesting that a fetal skin signature is expressed in adult inflamed skin. Furthermore, differences in immune cell composition between healthy fetal and adult skin and that of individuals suffering from disease were observed.

Science , this issue p. eaba6500

Found

1 citation

Begall Sabine

94 publications, 1 962 citations, 5 reviews

h-index: 25

University of Duisburg-Essen

1 citation

Malleret Benoit

103 publications, 9 642 citations, 13 reviews

h-index: 42

Agency for Science, Technology and Research

National University of Singapore

Top-30

Journals

	5 10 15 20 25 30 35
Journal of Investigative Dermatology	Journal of Investigative Dermatology, 34, 8.1% Journal of Investigative Dermatology 34 publications, 8.1%
Frontiers in Immunology	Frontiers in Immunology, 23, 5.48% Frontiers in Immunology 23 publications, 5.48%
Nature Communications	Nature Communications, 17, 4.05% Nature Communications 17 publications, 4.05%
Immunity	Immunity, 11, 2.62% Immunity 11 publications, 2.62%
Journal of Allergy and Clinical Immunology	Journal of Allergy and Clinical Immunology, 10, 2.38% Journal of Allergy and Clinical Immunology 10 publications, 2.38%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 8, 1.9% International Journal of Molecular Sciences 8 publications, 1.9%
Experimental Dermatology	Experimental Dermatology, 7, 1.67% Experimental Dermatology 7 publications, 1.67%
Science immunology	Science immunology, 7, 1.67% Science immunology 7 publications, 1.67%
bioRxiv	bioRxiv, 7, 1.67% bioRxiv 7 publications, 1.67%
Nature Immunology	Nature Immunology, 6, 1.43% Nature Immunology 6 publications, 1.43%
Cell Reports	Cell Reports, 6, 1.43% Cell Reports 6 publications, 1.43%
Allergy: European Journal of Allergy and Clinical Immunology	Allergy: European Journal of Allergy and Clinical Immunology, 6, 1.43% Allergy: European Journal of Allergy and Clinical Immunology 6 publications, 1.43%
Cellular and Molecular Immunology	Cellular and Molecular Immunology, 5, 1.19% Cellular and Molecular Immunology 5 publications, 1.19%
European Journal of Immunology	European Journal of Immunology, 5, 1.19% European Journal of Immunology 5 publications, 1.19%
Journal of Clinical Investigation	Journal of Clinical Investigation, 5, 1.19% Journal of Clinical Investigation 5 publications, 1.19%
Journal of Experimental Medicine	Journal of Experimental Medicine, 5, 1.19% Journal of Experimental Medicine 5 publications, 1.19%
Journal of Dermatological Science	Journal of Dermatological Science, 5, 1.19% Journal of Dermatological Science 5 publications, 1.19%
Nature Genetics	Nature Genetics, 4, 0.95% Nature Genetics 4 publications, 0.95%
Frontiers in Cell and Developmental Biology	Frontiers in Cell and Developmental Biology, 4, 0.95% Frontiers in Cell and Developmental Biology 4 publications, 0.95%
Biomedicines	Biomedicines, 4, 0.95% Biomedicines 4 publications, 0.95%
International Immunopharmacology	International Immunopharmacology, 4, 0.95% International Immunopharmacology 4 publications, 0.95%
Immunological Reviews	Immunological Reviews, 4, 0.95% Immunological Reviews 4 publications, 0.95%
Clinical Immunology	Clinical Immunology, 4, 0.95% Clinical Immunology 4 publications, 0.95%
Advanced Science	Advanced Science, 4, 0.95% Advanced Science 4 publications, 0.95%
Journal of Immunology	Journal of Immunology, 3, 0.71% Journal of Immunology 3 publications, 0.71%
Nature	Nature, 3, 0.71% Nature 3 publications, 0.71%
Cell	Cell, 3, 0.71% Cell 3 publications, 0.71%
Cell Reports Medicine	Cell Reports Medicine, 3, 0.71% Cell Reports Medicine 3 publications, 0.71%
Cell Stem Cell	Cell Stem Cell, 3, 0.71% Cell Stem Cell 3 publications, 0.71%
	5 10 15 20 25 30 35

Publishers

	20 40 60 80 100 120
Elsevier	Elsevier, 116, 27.62% Elsevier 116 publications, 27.62%
Springer Nature	Springer Nature, 73, 17.38% Springer Nature 73 publications, 17.38%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 49, 11.67% Cold Spring Harbor Laboratory 49 publications, 11.67%
Wiley	Wiley, 49, 11.67% Wiley 49 publications, 11.67%
Frontiers Media S.A.	Frontiers Media S.A., 37, 8.81% Frontiers Media S.A. 37 publications, 8.81%
MDPI	MDPI, 22, 5.24% MDPI 22 publications, 5.24%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 10, 2.38% American Association for the Advancement of Science (AAAS) 10 publications, 2.38%
Oxford University Press	Oxford University Press, 7, 1.67% Oxford University Press 7 publications, 1.67%
American Society for Clinical Investigation	American Society for Clinical Investigation, 6, 1.43% American Society for Clinical Investigation 6 publications, 1.43%
Rockefeller University Press	Rockefeller University Press, 5, 1.19% Rockefeller University Press 5 publications, 1.19%
Taylor & Francis	Taylor & Francis, 5, 1.19% Taylor & Francis 5 publications, 1.19%
American Chemical Society (ACS)	American Chemical Society (ACS), 4, 0.95% American Chemical Society (ACS) 4 publications, 0.95%
Ovid Technologies (Wolters Kluwer Health)	Ovid Technologies (Wolters Kluwer Health), 3, 0.71% Ovid Technologies (Wolters Kluwer Health) 3 publications, 0.71%
SAGE	SAGE, 3, 0.71% SAGE 3 publications, 0.71%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 3, 0.71% Proceedings of the National Academy of Sciences (PNAS) 3 publications, 0.71%
The American Association of Immunologists	The American Association of Immunologists, 2, 0.48% The American Association of Immunologists 2 publications, 0.48%
F1000 Research	F1000 Research, 2, 0.48% F1000 Research 2 publications, 0.48%
Portland Press	Portland Press, 2, 0.48% Portland Press 2 publications, 0.48%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 2, 0.48% Public Library of Science (PLoS) 2 publications, 0.48%
Annual Reviews	Annual Reviews, 2, 0.48% Annual Reviews 2 publications, 0.48%
BMJ	BMJ, 1, 0.24% BMJ 1 publication, 0.24%
Institute of Electrical and Electronics Engineers (IEEE)	Institute of Electrical and Electronics Engineers (IEEE), 1, 0.24% Institute of Electrical and Electronics Engineers (IEEE) 1 publication, 0.24%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 1, 0.24% American Association for Cancer Research (AACR) 1 publication, 0.24%
Impact Journals	Impact Journals, 1, 0.24% Impact Journals 1 publication, 0.24%
NII KPSSZ	NII KPSSZ, 1, 0.24% NII KPSSZ 1 publication, 0.24%
The Company of Biologists	The Company of Biologists, 1, 0.24% The Company of Biologists 1 publication, 0.24%
Institute of Cytology and Genetics SB RAS	Institute of Cytology and Genetics SB RAS, 1, 0.24% Institute of Cytology and Genetics SB RAS 1 publication, 0.24%
	20 40 60 80 100 120

We do not take into account publications without a DOI.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

PDF

Metrics

421

Cite this

GOST |

Cite this

GOST Copy

Reynolds G. et al. Developmental cell programs are co-opted in inflammatory skin disease // Science. 2021. Vol. 371. No. 6527.

GOST all authors (up to 50) Copy

Reynolds G. et al. Developmental cell programs are co-opted in inflammatory skin disease // Science. 2021. Vol. 371. No. 6527.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1126/science.aba6500

UR - https://doi.org/10.1126/science.aba6500

TI - Developmental cell programs are co-opted in inflammatory skin disease

T2 - Science

AU - Reynolds, Gary

AU - Vegh, Peter

AU - Fletcher, James

AU - Poyner, Elizabeth F M

AU - Stephenson, Emily

AU - Goh, Issac

AU - Botting, Rachel Anne

AU - Huang, Ni

AU - Olabi, Bayanne

AU - Dubois, A

AU - Dixon, David

AU - Green, Kile

AU - Maunder, Daniel

AU - Engelbert, Justin

AU - Efremova, Mirjana

AU - Polanski, Krzysztof

AU - Jardine, Laura

AU - Jones, Claire J.

AU - Ness, Thomas

AU - Horsfall, Dave

AU - Mcgrath, Jim

AU - Carey, C. S.

AU - Popescu, Dorin Mirel

AU - Webb, Simone

AU - Wang, Xiao-Nong

AU - Sayer, Ben

AU - Park, Jong-Eun

AU - Negri, Victor A

AU - Belokhvostova, Daria

AU - Lynch, Magnus D.

AU - Mcdonald, David

AU - Filby, Andrew

AU - Hagai, Tzachi

AU - Meyer, Kerstin B.

AU - Husain, A

AU - Coxhead, Jonathan

AU - Vento-Tormo, Roser

AU - Behjati, Sam

AU - Lisgo, S.

AU - Villani, Alexandra-Chloe

AU - Bacardit, Jaume

AU - Jones, Philip H

AU - O'Toole, Edel A.

AU - Ogg, Graham

AU - Rajan, Neil

AU - Reynolds, N

AU - Teichmann, Sarah A.

AU - Watt, F. M.

AU - Haniffa, Muzlifah A.

PY - 2021

DA - 2021/01/22

PB - American Association for the Advancement of Science (AAAS)

IS - 6527

VL - 371

PMID - 33479125

SN - 0036-8075

SN - 1095-9203

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2021_Reynolds,

author = {Gary Reynolds and Peter Vegh and James Fletcher and Elizabeth F M Poyner and Emily Stephenson and Issac Goh and Rachel Anne Botting and Ni Huang and Bayanne Olabi and A Dubois and David Dixon and Kile Green and Daniel Maunder and Justin Engelbert and Mirjana Efremova and Krzysztof Polanski and Laura Jardine and Claire J. Jones and Thomas Ness and Dave Horsfall and Jim Mcgrath and C. S. Carey and Dorin Mirel Popescu and Simone Webb and Xiao-Nong Wang and Ben Sayer and Jong-Eun Park and Victor A Negri and Daria Belokhvostova and Magnus D. Lynch and David Mcdonald and Andrew Filby and Tzachi Hagai and Kerstin B. Meyer and A Husain and Jonathan Coxhead and Roser Vento-Tormo and Sam Behjati and S. Lisgo and Alexandra-Chloe Villani and Jaume Bacardit and Philip H Jones and Edel A. O'Toole and Graham Ogg and Neil Rajan and N Reynolds and Sarah A. Teichmann and F. M. Watt and Muzlifah A. Haniffa and others},

title = {Developmental cell programs are co-opted in inflammatory skin disease},

journal = {Science},

year = {2021},

volume = {371},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {jan},

url = {https://doi.org/10.1126/science.aba6500},

number = {6527},

doi = {10.1126/science.aba6500}

}

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science

scimago Q1

wos Q1

SJR

10.416

CiteScore

48.4

Impact factor

45.8

ISSN

00368075 (Print)

10959203 (Electronic)