Open Access
Reactivation of the pluripotency program precedes formation of the cranial neural crest
Antoine Zalc
1
,
Rahul Sinha
2
,
Gunsagar Gulati
2
,
Daniel J Wesche
2
,
Patrycja Daszczuk
1
,
Tomek Swigut
1
,
Irving Weissman
2
,
Joanna Wysocka
1, 2, 3, 4
Publication type: Journal Article
Publication date: 2021-02-05
scimago Q1
wos Q1
SJR: 10.416
CiteScore: 48.4
Impact factor: 45.8
ISSN: 00368075, 10959203
PubMed ID:
33542111
Multidisciplinary
Abstract
Reactivating neural crest pluripotency
Cranial neural crest cells (CNCCs) are a transient cell group with an extraordinary differentiation potential that extends beyond its ectodermal lineage to form the majority of facial mesenchyme. Zalc et al. identified a neuroepithelial precursor population that transiently reactivates pluripotency factors to generate CNCCs. The pluripotency factor Oct4 is required for the expansion of CNCC developmental potential to form facial mesenchyme. Analysis of the chromatin landscape of Oct4 + CNCC precursors showed that these cells resemble those of epiblast stem cells, with additional features suggestive of future priming for neural crest programs. Thus, to expand their cellular potency, CNCC precursors undergo a natural in vivo reprogramming event.
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127
Total citations:
127
Citations from 2024:
50
(39.68%)
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Zalc A. et al. Reactivation of the pluripotency program precedes formation of the cranial neural crest // Science. 2021. Vol. 371. No. 6529.
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Zalc A., Sinha R., Gulati G., Wesche D. J., Daszczuk P., Swigut T., Weissman I., Wysocka J. Reactivation of the pluripotency program precedes formation of the cranial neural crest // Science. 2021. Vol. 371. No. 6529.
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TY - JOUR
DO - 10.1126/science.abb4776
UR - https://doi.org/10.1126/science.abb4776
TI - Reactivation of the pluripotency program precedes formation of the cranial neural crest
T2 - Science
AU - Zalc, Antoine
AU - Sinha, Rahul
AU - Gulati, Gunsagar
AU - Wesche, Daniel J
AU - Daszczuk, Patrycja
AU - Swigut, Tomek
AU - Weissman, Irving
AU - Wysocka, Joanna
PY - 2021
DA - 2021/02/05
PB - American Association for the Advancement of Science (AAAS)
IS - 6529
VL - 371
PMID - 33542111
SN - 0036-8075
SN - 1095-9203
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Zalc,
author = {Antoine Zalc and Rahul Sinha and Gunsagar Gulati and Daniel J Wesche and Patrycja Daszczuk and Tomek Swigut and Irving Weissman and Joanna Wysocka},
title = {Reactivation of the pluripotency program precedes formation of the cranial neural crest},
journal = {Science},
year = {2021},
volume = {371},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {feb},
url = {https://doi.org/10.1126/science.abb4776},
number = {6529},
doi = {10.1126/science.abb4776}
}