Open Access

Science, volume 369, issue 6508, pages 1255-1260

Evolution and epidemic spread of SARS-CoV-2 in Brazil

Darlan S. Candido ^{1, 2}

Ingra M. Claro ^{2, 3}

Jaqueline G. de Jesus ^{2, 3}

William Marciel de Souza ⁴

Filipe R R Moreira ⁵

Simon Dellicour ^{6, 7}

Thomas A. Mellan ⁸

Louis du Plessis ¹

Rafael H M Pereira ⁹

Flávia C. Silva Sales ^{2, 3}

Erika R. Manuli ^{2, 3}

Julien Thézé ¹⁰

Luiz Domingues Almeida Junior ¹¹

Mariane Talon de Menezes ⁵

Carolina M. Voloch ⁵

Marcílio Jorge Fumagalli ⁴

Thais M. Coletti ^{2, 3}

Camila A. M. da Silva ^{2, 3}

Mariana S. Ramundo ^{2, 3}

Mariene R. Amorim ¹²

Henrique Hoeltgebaum ¹³

Swapnil Mishra ⁸

Mandev S. Gill ⁷

Luiz Max Carvalho ¹⁴

Lewis Buss ²

Carlos A Prete ¹⁵

Jordan Ashworth ¹⁶

Helder I. Nakaya ¹⁷

Pedro S. Peixoto ¹⁸

Oliver J. Brady ^{19, 20}

Samuel M Nicholls ²¹

Amilcar Tanuri ⁵

Atila Rossi ⁵

Carlos K V Braga ⁹

Alexandra L. Gerber ¹¹

Ana Paula de C. Guimarães ¹¹

Nelson Gaburo ²²

Cecilia Salete Alencar ²³

Alessandro C S Ferreira ²⁴

Cristiano X. Lima ^{25, 26}

José Eduardo Levi ²⁷

Celso Granato ²⁸

Giulia Magalhães Ferreira ²⁹

Ronaldo da Silva Francisco ¹¹

Fabiana Granja ^{12, 30}

Márcia Teixeira Garcia ³¹

Maria Luiza Moretti ³¹

Maurício WP Junior ³²

Terezinha M. P. P. Castiñeiras ³³

Carolina S Lazari ³⁴

Sarah C. Hill ^{1, 35}

Andreza Aruska De Souza Santos ³⁶

Camila L. Simeoni ¹²

Julia Forato ¹²

Andrei C. Sposito ³⁷

Angélica Z Schreiber ³⁸

Magnun N N Santos ³⁸

Camila Zolini De Sá ³⁹

Renan P. Souza ³⁹

Luciana C Resende Moreira ⁴⁰

Mauro M Teixeira ⁴¹

Josy Hubner ⁴²

Patricia A.F. Leme ⁴³

Rennan G. Moreira ⁴⁴

Mauricio L. Nogueira ⁴⁵

Neil M Ferguson ⁸

Silvia M. Costa ^{2, 3}

José Luiz Proença-Módena ¹²

Ana Vasconcelos ¹¹

SAMIR M. BHATT ⁸

Philippe Lemey ⁷

Chieh-Hsi Wu ⁴⁶

Andrew Rambaut ⁴⁷

Nick Loman ²¹

Renato S. Aguiar ³⁹

Mark Danta ¹

Ester Sabino ^{2, 3}

Nuno A. Faria ^{1, 2, 8}

Show full list: 78 authors

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Department of Zoology, University of Oxford, Oxford, UK. |

Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. |

Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. |

⁴

Centro de Pesquisa em Virologia, Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto, Brazil. |

⁵

Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. |

⁶

Spatial Epidemiology Lab, Université Libre de Bruxelles, Brussels, Belgium. |

⁷

Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium. |

⁸

MRC Centre for Global Infectious Disease Analysis, J-IDEA, Imperial College London, London, UK. |

⁹

Institute for Applied Economic Research, Brasília, Brazil. |

¹⁰

Université Clermont Auvergne, INRAE, VetAgro Sup, UMR EPIA, Saint-Genès-Champanelle, France. |

¹¹

Laboratório de Bioinformática, Laboratório Nacional de Computação Científica, Petrópolis, Brazil. |

¹²

Departamento de Genética, Evolução, Microbiologia e Imunologia, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Brazil. |

¹³

Department of Mathematics, Imperial College London, London, UK. |

¹⁴

Escola de Matemática Aplicada (EMAp), Fundação Getúlio Vargas, Rio de Janeiro, Brazil. |

¹⁵

Department of Electronic Systems Engineering, University of São Paulo, São Paulo, Brazil. |

¹⁶

Usher Institute, University of Edinburgh, Edinburgh, UK. |

¹⁷

Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil. |

¹⁸

Departamento de Matemática Aplicada, Instituto de Matemática e Estatística, Universidade de São Paulo, São Paulo, Brazil. |

¹⁹

Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK. |

²⁰

Centre for the Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, UK. |

²¹

Institute for Microbiology and Infection, University of Birmingham, Birmingham, UK. |

²²

DB Diagnósticos do Brasil, São Paulo, Brazil. |

²³

LIM 03 Laboratório de Medicina Laboratorial, Hospital das Clínicas Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. |

²⁴

Instituto Hermes Pardini, Belo Horizonte, Brazil. |

²⁵

Departamento de Cirurgia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. |

²⁶

Simile Instituto de Imunologia Aplicada Ltda, Belo Horizonte, Brazil. |

²⁷

Laboratório DASA, São Paulo, Brazil. |

²⁸

Laboratório Fleury, São Paulo, Brazil. |

²⁹

Laboratório de Virologia, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, Brazil. |

³⁰

Centro de Estudos da Biodiversidade, Universidade Federal de Roraima, Boa Vista, Brazil. |

³¹

Divisão de Doenças Infecciosas, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, Brazil. |

³²

Hospital Estadual Sumaré, Universidade Estadual de Campinas, Campinas, Brazil. |

³³

Departamento de Doenças Infecciosas e Parasitárias, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. |

³⁴

Divisão de Laboratório Central do Hospital das Clínicas, da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. |

³⁵

Department of Pathobiology and Population Sciences, Royal Veterinary College, Hatfield, UK. |

³⁶

University of Oxford, Latin American Centre, Oxford School of Global and Area Studies, Oxford, UK. |

³⁷

Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, Brazil. |

³⁸

Departamento de Patologia Clínica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, Brazil. |

³⁹

Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. |

⁴⁰

Departamento de Botânica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. |

⁴¹

Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. |

⁴²

Departamento de Biologia Celular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. |

⁴³

Centro de Saúde da Comunidade, Universidade Estadual de Campinas, Campinas, Brazil. |

⁴⁴

Centro de Laboratórios Multiusuários, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. |

⁴⁵

Laboratório de Pesquisas em Virologia, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil. |

⁴⁶

Mathematical Sciences, University of Southampton, Southampton, UK. |

⁴⁷

Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK. |

Publication type: Journal Article

Publication date: 2020-09-04

American Association for the Advancement of Science (AAAS)

Journal: Science

scimago Q1

SJR: 11.902

CiteScore: 61.1

Impact factor: 44.7

ISSN: 00368075, 10959203

DOI: 10.1126/science.abd2161

Copy DOI

Multidisciplinary

Abstract

The spread of SARS-CoV-2 in Brazil

Brazil has been hard-hit by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Candido et al. combined genomic and epidemiological analyses to investigate the impact of nonpharmaceutical interventions (NPIs) in the country. By setting up a network of genomic laboratories using harmonized protocols, the researchers found a 29% positive rate for SARS-CoV-2 among collected samples. More than 100 international introductions of SARS-CoV-2 into Brazil were identified, including three clades introduced from Europe that were already well established before the implementation of NPIs and travel bans. The virus spread from urban centers to the rest of the country, along with a 25% increase in the average distance traveled by air passengers before travel bans, despite an overall drop in short-haul travel. Unfortunately, the evidence confirms that current interventions remain insufficient to keep virus transmission under control in Brazil.

Science , this issue p. 1255

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RIS Copy

TY - JOUR

DO - 10.1126/science.abd2161

UR - https://doi.org/10.1126/science.abd2161

TI - Evolution and epidemic spread of SARS-CoV-2 in Brazil

T2 - Science

AU - Candido, Darlan S.

AU - Claro, Ingra M.

AU - de Jesus, Jaqueline G.

AU - Souza, William Marciel de

AU - Moreira, Filipe R R

AU - Dellicour, Simon

AU - Mellan, Thomas A.

AU - du Plessis, Louis

AU - Pereira, Rafael H M

AU - Silva Sales, Flávia C.

AU - Manuli, Erika R.

AU - Thézé, Julien

AU - Almeida Junior, Luiz Domingues

AU - de Menezes, Mariane Talon

AU - Voloch, Carolina M.

AU - Fumagalli, Marcílio Jorge

AU - Coletti, Thais M.

AU - da Silva, Camila A. M.

AU - Ramundo, Mariana S.

AU - Amorim, Mariene R.

AU - Hoeltgebaum, Henrique

AU - Mishra, Swapnil

AU - Gill, Mandev S.

AU - Carvalho, Luiz Max

AU - Buss, Lewis

AU - Prete, Carlos A

AU - Ashworth, Jordan

AU - Nakaya, Helder I.

AU - Peixoto, Pedro S.

AU - Brady, Oliver J.

AU - Nicholls, Samuel M

AU - Tanuri, Amilcar

AU - Rossi, Atila

AU - Braga, Carlos K V

AU - Gerber, Alexandra L.

AU - Guimarães, Ana Paula de C.

AU - Gaburo, Nelson

AU - Alencar, Cecilia Salete

AU - Ferreira, Alessandro C S

AU - Lima, Cristiano X.

AU - Levi, José Eduardo

AU - Granato, Celso

AU - Ferreira, Giulia Magalhães

AU - Francisco, Ronaldo da Silva

AU - Granja, Fabiana

AU - Garcia, Márcia Teixeira

AU - Moretti, Maria Luiza

AU - Junior, Maurício WP

AU - Castiñeiras, Terezinha M. P. P.

AU - Lazari, Carolina S

AU - Hill, Sarah C.

AU - De Souza Santos, Andreza Aruska

AU - Simeoni, Camila L.

AU - Forato, Julia

AU - Sposito, Andrei C.

AU - Schreiber, Angélica Z

AU - Santos, Magnun N N

AU - De Sá, Camila Zolini

AU - Souza, Renan P.

AU - Resende Moreira, Luciana C

AU - Teixeira, Mauro M

AU - Hubner, Josy

AU - Leme, Patricia A.F.

AU - Moreira, Rennan G.

AU - Nogueira, Mauricio L.

AU - Ferguson, Neil M

AU - Costa, Silvia M.

AU - Proença-Módena, José Luiz

AU - Vasconcelos, Ana

AU - BHATT, SAMIR M.

AU - Lemey, Philippe

AU - Wu, Chieh-Hsi

AU - Rambaut, Andrew

AU - Loman, Nick

AU - Aguiar, Renato S.

AU - Danta, Mark

AU - Sabino, Ester

AU - Faria, Nuno A.

PY - 2020

DA - 2020/09/04

PB - American Association for the Advancement of Science (AAAS)

SP - 1255-1260

IS - 6508

VL - 369

SN - 0036-8075

SN - 1095-9203

ER -

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@article{2020_Candido,

author = {Darlan S. Candido and Ingra M. Claro and Jaqueline G. de Jesus and William Marciel de Souza and Filipe R R Moreira and Simon Dellicour and Thomas A. Mellan and Louis du Plessis and Rafael H M Pereira and Flávia C. Silva Sales and Erika R. Manuli and Julien Thézé and Luiz Domingues Almeida Junior and Mariane Talon de Menezes and Carolina M. Voloch and Marcílio Jorge Fumagalli and Thais M. Coletti and Camila A. M. da Silva and Mariana S. Ramundo and Mariene R. Amorim and Henrique Hoeltgebaum and Swapnil Mishra and Mandev S. Gill and Luiz Max Carvalho and Lewis Buss and Carlos A Prete and Jordan Ashworth and Helder I. Nakaya and Pedro S. Peixoto and Oliver J. Brady and Samuel M Nicholls and Amilcar Tanuri and Atila Rossi and Carlos K V Braga and Alexandra L. Gerber and Ana Paula de C. Guimarães and Nelson Gaburo and Cecilia Salete Alencar and Alessandro C S Ferreira and Cristiano X. Lima and José Eduardo Levi and Celso Granato and Giulia Magalhães Ferreira and Ronaldo da Silva Francisco and Fabiana Granja and Márcia Teixeira Garcia and Maria Luiza Moretti and Maurício WP Junior and Terezinha M. P. P. Castiñeiras and Carolina S Lazari and others},

title = {Evolution and epidemic spread of SARS-CoV-2 in Brazil},

journal = {Science},

year = {2020},

volume = {369},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {sep},

url = {https://doi.org/10.1126/science.abd2161},

number = {6508},

pages = {1255--1260},

doi = {10.1126/science.abd2161}

}

MLA

Found error?

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science

scimago Q1

SJR

11.902

CiteScore

61.1

Impact factor

44.7

ISSN

00368075 (Print)

10959203 (Electronic)

Evolution and epidemic spread of SARS-CoV-2 in Brazil

The spread of SARS-CoV-2 in Brazil

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