Open Access
Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis
Kjetil Bjornevik
1
,
Marianna Cortese
1
,
B. Healy
2, 3, 4
,
Jens Kuhle
5
,
Michael J. Mina
6, 7, 8
,
Yumei Leng
6
,
Stephen J. Elledge
6
,
David W. Niebuhr
9
,
Ann I. Scher
9
,
K. L. Munger
1
,
A Ascherio
1, 10, 11
6
8
Publication type: Journal Article
Publication date: 2022-01-21
scimago Q1
wos Q1
SJR: 10.416
CiteScore: 48.4
Impact factor: 45.8
ISSN: 00368075, 10959203
PubMed ID:
35025605
Multidisciplinary
Abstract
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system of unknown etiology. We tested the hypothesis that MS is caused by Epstein-Barr virus (EBV) in a cohort comprising more than 10 million young adults on active duty in the US military, 955 of whom were diagnosed with MS during their period of service. Risk of MS increased 32-fold after infection with EBV but was not increased after infection with other viruses, including the similarly transmitted cytomegalovirus. Serum levels of neurofilament light chain, a biomarker of neuroaxonal degeneration, increased only after EBV seroconversion. These findings cannot be explained by any known risk factor for MS and suggest EBV as the leading cause of MS.
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Total citations:
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Citations from 2024:
804
(51.83%)
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GOST
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Bjornevik K. et al. Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis // Science. 2022. Vol. 375. No. 6578. pp. 296-301.
GOST all authors (up to 50)
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Bjornevik K., Cortese M., Healy B., Kuhle J., Mina M. J., Leng Y., Elledge S. J., Niebuhr D. W., Scher A. I., Munger K. L., Ascherio A. Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis // Science. 2022. Vol. 375. No. 6578. pp. 296-301.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1126/science.abj8222
UR - https://doi.org/10.1126/science.abj8222
TI - Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis
T2 - Science
AU - Bjornevik, Kjetil
AU - Cortese, Marianna
AU - Healy, B.
AU - Kuhle, Jens
AU - Mina, Michael J.
AU - Leng, Yumei
AU - Elledge, Stephen J.
AU - Niebuhr, David W.
AU - Scher, Ann I.
AU - Munger, K. L.
AU - Ascherio, A
PY - 2022
DA - 2022/01/21
PB - American Association for the Advancement of Science (AAAS)
SP - 296-301
IS - 6578
VL - 375
PMID - 35025605
SN - 0036-8075
SN - 1095-9203
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2022_Bjornevik,
author = {Kjetil Bjornevik and Marianna Cortese and B. Healy and Jens Kuhle and Michael J. Mina and Yumei Leng and Stephen J. Elledge and David W. Niebuhr and Ann I. Scher and K. L. Munger and A Ascherio},
title = {Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis},
journal = {Science},
year = {2022},
volume = {375},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {jan},
url = {https://doi.org/10.1126/science.abj8222},
number = {6578},
pages = {296--301},
doi = {10.1126/science.abj8222}
}
Cite this
MLA
Copy
Bjornevik, Kjetil, et al. “Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis.” Science, vol. 375, no. 6578, Jan. 2022, pp. 296-301. https://doi.org/10.1126/science.abj8222.