Open Access
Science, volume 374, issue 6571, pages 1106-1113
Impact of neurodegenerative diseases on human adult hippocampal neurogenesis
J Terreros-Roncal
1, 2, 3
,
Elena P. Moreno-Jiménez
1, 2, 3
,
Miguel Flor-García
1, 2, 3
,
C B Rodríguez Moreno
1, 3
,
M F Trinchero
4
,
F CAFINI
5
,
Alberto R??bano
6
,
M Llorens-Martín
1, 3
2
3
Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
|
4
Laboratory of Neuronal Plasticity, Leloir Institute (IIBBA-CONICET), Buenos Aires, Argentina.
|
6
Neuropathology Department, CIEN Foundation, Madrid, Spain.
|
Publication type: Journal Article
Publication date: 2021-11-26
Journal:
Science
scimago Q1
SJR: 11.902
CiteScore: 61.1
Impact factor: 44.7
ISSN: 00368075, 10959203
Multidisciplinary
Abstract
Disease and hippocampal dysfunction
Impaired function of the brain’s hippocampus can underpin psychiatric symptoms and cognitive impairment. Looking at postmortem brain samples from patients affected by any of several neurodegenerative disorders, Terreros-Roncal et al . investigated whether adult neurogenesis was disrupted (see the Perspective by Gage). Indeed, functions of the neurogenic niche shifted and the cells produced were abnormal in shape and differentiation. The neuronal plasticity characteristic of the hippocampus may make it especially susceptible to the ravages of neurodegenerative disease. —PJH
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