Human dendritic cells in cancer
2
5
6
Publication type: Journal Article
Publication date: 2022-04-11
scimago Q1
wos Q1
SJR: 8.220
CiteScore: 26.9
Impact factor: 16.3
ISSN: 24709468
PubMed ID:
35363544
General Medicine
Immunology
Abstract
Dendritic cells (DCs) are professional antigen-presenting cells, orchestrating innate and adaptive immunity during infections, autoimmune diseases, and malignancies. Since the discovery of DCs almost 50 years ago, our understanding of their biology in humans has increased substantially. Here, we review both antitumor and tolerogenic DC responses in cancer and discuss lineage-specific contributions by their functionally specialized subsets, including the conventional DC (cDC) subsets cDC1 and cDC2, the newly described DC3, and the plasmacytoid DCs (pDCs), focusing on the human setting. In addition, we review the lineage-unrestricted “mature DCs enriched in immunoregulatory molecules” (mregDC) state recently described across different human tumors.
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Metrics
191
Total citations:
191
Citations from 2024:
117
(61.26%)
Cite this
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Cite this
RIS
Copy
TY - JOUR
DO - 10.1126/sciimmunol.abm9409
UR - https://doi.org/10.1126/sciimmunol.abm9409
TI - Human dendritic cells in cancer
T2 - Science immunology
AU - Kvedaraite, Egle
AU - Ginhoux, Florent
PY - 2022
DA - 2022/04/11
PB - American Association for the Advancement of Science (AAAS)
IS - 70
VL - 7
PMID - 35363544
SN - 2470-9468
ER -
Cite this
BibTex (up to 50 authors)
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@article{2022_Kvedaraite,
author = {Egle Kvedaraite and Florent Ginhoux},
title = {Human dendritic cells in cancer},
journal = {Science immunology},
year = {2022},
volume = {7},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {apr},
url = {https://doi.org/10.1126/sciimmunol.abm9409},
number = {70},
doi = {10.1126/sciimmunol.abm9409}
}