American Association for the Advancement of Science (AAAS)

Science Translational Medicine

, volume 12 , issue 572

Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis

Olivier Govaere ¹

Simon Cockell ²

Dina G Tiniakos ^{1, 3}

Rachel Queen ²

Ramy Younes ^{1, 4}

Michele Vacca ⁵

Leigh Alexander ⁶

Federico Ravaioli ^{1, 7}

Jeremy Palmer ¹

Salvatore Petta ⁸

Jerome Boursier ⁹

C. Rosso ⁴

Katherine Johnson ¹

Kristy Wonders ¹

Christopher P. Day ¹

Mattias Ekstedt ¹⁰

Matej Orešič ¹¹

Rebecca Darlay ¹²

Heather J. Cordell ¹²

F.P. Marra ¹³

Antonio Vidal-Puig ⁵

Pierre Bedossa ^{1, 14}

Jörn M. Schattenberg ¹⁵

Karine Clément ¹⁶

Michael Allison ¹⁷

Elisabetta Bugianesi ⁴

Vlad Ratziu ¹⁴

A. Daly ¹

Annalisa Berzigotti ^{1, 18}

Hide authors affiliations Show authors affiliations: 18 affiliations

Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. |

Bioinformatics Support Unit, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. |

Department of Pathology, Aretaieio Hospital, National and Kapodistrian University of Athens, 15771 Athens, Greece. |

⁴

Department of Medical Sciences, Division of Gastro-Hepatology, A.O. Città della Salute e della Scienza di Torino, University of Turin, 10124 Turin, Italy. |

⁵

University of Cambridge Metabolic Research Laboratories, Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK. |

⁶

SomaLogic Inc., Boulder, CO 80301, USA. |

⁷

Department of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, Italy. |

⁸

Sezione di Gastroenterologia, Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, 90133 Palermo, Italy. |

⁹

Hepatology Department, Angers University Hospital, 49933 Angers, France. |

¹⁰

Department of Health, Medicine and Caring Sciences, Linköping University, 581 83 Linköping, Sweden. |

¹¹

School of Medical Sciences, Örebro University, 702 81 Örebro, Sweden. |

¹²

Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. |

¹³

Dipartimento di Medicina Sperimentale e Clinica, University of Florence, 50121 Florence, Italy. |

¹⁴

Assistance Publique–Hôpitaux de Paris, Hôpital Pitié Salpêtrière, Sorbonne University, ICAN (Institute of Cardiometabolism and Nutrition), 75013 Paris, France. |

¹⁵

Department of Medicine, University Hospital Mainz, 55131 Mainz, Germany. |

¹⁶

Nutrition and Obesities: Systemic Approaches, INSERM, Sorbonne University, 75006 Paris, France.

Sorbonne University

French Institute of Health and Medical Research

¹⁷

Liver Unit, Department of Medicine, NIHR Cambridge Biomedical Research Centre, Cambridge University NHS Foundation Trust, Cambridge CB2 0QQ, UK.

University of Cambridge

NIHR Cambridge Biomedical Research Centre

¹⁸

NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne NE7 7DN, UK. |

Publication type: Journal Article

Publication date: 2020-12-02

American Association for the Advancement of Science (AAAS)

Science Translational Medicine

scimago Q1

wos Q1

SJR: 6.722

CiteScore: 27.9

Impact factor: 14.6

ISSN: 19466234, 19466242

DOI: 10.1126/scitranslmed.aba4448

Copy DOI

PubMed ID: 33268509

General Medicine

Abstract

A 25-gene expression signature associates with progression of fibrosing steatohepatitis in independent NAFLD cohorts.

Found

1 citation

Huang Wei

11 publications, 160 citations

h-index: 7

China Institute of Water Resources and Hydropower Research

1 citation

Juul Jens

PhD, lecturer

1 787 publications, 118 333 citations, 107 reviews

h-index: 168

University of Copenhagen

1 citation

Muller Werner

professor, full member of the Academia Europaea

260 publications, 31 303 citations

h-index: 82

University of Manchester

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Cite this

GOST |

Cite this

GOST Copy

Govaere O. et al. Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis // Science Translational Medicine. 2020. Vol. 12. No. 572.

GOST all authors (up to 50) Copy

Govaere O., Cockell S., Tiniakos D. G., Queen R., Younes R., Vacca M., Alexander L., Ravaioli F., Palmer J., Petta S., Boursier J., Rosso C., Johnson K., Wonders K., Day C. P., Ekstedt M., Orešič M., Darlay R., Cordell H. J., Marra F., Vidal-Puig A., Bedossa P., Schattenberg J. M., Clément K., Allison M., Bugianesi E., Ratziu V., Daly A., Berzigotti A. Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis // Science Translational Medicine. 2020. Vol. 12. No. 572.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1126/scitranslmed.aba4448

UR - https://doi.org/10.1126/scitranslmed.aba4448

TI - Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis

T2 - Science Translational Medicine

AU - Govaere, Olivier

AU - Cockell, Simon

AU - Tiniakos, Dina G

AU - Queen, Rachel

AU - Younes, Ramy

AU - Vacca, Michele

AU - Alexander, Leigh

AU - Ravaioli, Federico

AU - Palmer, Jeremy

AU - Petta, Salvatore

AU - Boursier, Jerome

AU - Rosso, C.

AU - Johnson, Katherine

AU - Wonders, Kristy

AU - Day, Christopher P.

AU - Ekstedt, Mattias

AU - Orešič, Matej

AU - Darlay, Rebecca

AU - Cordell, Heather J.

AU - Marra, F.P.

AU - Vidal-Puig, Antonio

AU - Bedossa, Pierre

AU - Schattenberg, Jörn M.

AU - Clément, Karine

AU - Allison, Michael

AU - Bugianesi, Elisabetta

AU - Ratziu, Vlad

AU - Daly, A.

AU - Berzigotti, Annalisa

PY - 2020

DA - 2020/12/02

PB - American Association for the Advancement of Science (AAAS)

IS - 572

VL - 12

PMID - 33268509

SN - 1946-6234

SN - 1946-6242

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2020_Govaere,

author = {Olivier Govaere and Simon Cockell and Dina G Tiniakos and Rachel Queen and Ramy Younes and Michele Vacca and Leigh Alexander and Federico Ravaioli and Jeremy Palmer and Salvatore Petta and Jerome Boursier and C. Rosso and Katherine Johnson and Kristy Wonders and Christopher P. Day and Mattias Ekstedt and Matej Orešič and Rebecca Darlay and Heather J. Cordell and F.P. Marra and Antonio Vidal-Puig and Pierre Bedossa and Jörn M. Schattenberg and Karine Clément and Michael Allison and Elisabetta Bugianesi and Vlad Ratziu and A. Daly and Annalisa Berzigotti},

title = {Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis},

journal = {Science Translational Medicine},

year = {2020},

volume = {12},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {dec},

url = {https://doi.org/10.1126/scitranslmed.aba4448},

number = {572},

doi = {10.1126/scitranslmed.aba4448}

}

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science Translational Medicine

scimago Q1

wos Q1

SJR

6.722

CiteScore

27.9

Impact factor

14.6

ISSN

19466234 (Print)

19466242 (Electronic)