Science Translational Medicine, volume 13, issue 621

An affinity-enhanced, broadly neutralizing heavy chain–only antibody protects against SARS-CoV-2 infection in animal models

B. Schepens ^{1, 2}

Loes Van Schie ^{1, 2}

Wim Nerinckx ^{1, 2}

K. Roose ^{1, 2}

Wander Van Breedam ^{1, 2}

Daria Fijałkowska ^{1, 2}

Simon Devos ^{1, 2}

Wannes Weyts ^{1, 2}

Sieglinde De Cae ^{1, 2}

Sandrine Vanmarcke ^{1, 2}

Chiara Lonigro ^{1, 2}

Hannah Eeckhaut ^{1, 2}

Dries Van Herpe ^{1, 2}

Jimmy Borloo ³

Ana Filipa Oliveira ³

J. P. Catani ^{1, 2}

Sarah Creytens ^{1, 2}

Dorien De Vlieger ^{1, 2}

Gitte Michielsen ^{1, 2}

Jackeline Cecilia Zavala Marchan ^{1, 2}

George D Moschonas ^{1, 2}

Iebe Rossey ^{1, 2}

Koen Sedeyn ^{1, 2}

Annelies Van Hecke ^{1, 2}

Xin Zhang ^{4, 5}

Lana Langendries ^{4, 5}

Sofie Jacobs ^{4, 5}

Sebastiaan Ter Horst ^{4, 5}

Laura Seldeslachts ⁶

Laurens Liesenborghs ^{4, 5}

Robbert Boudewijns ^{4, 5, 7}

Hendrik Jan Thibaut ^{4, 7, 8}

Kai Dallmeier ^{4, 5, 7}

Greetje Vande Velde ⁶

Birgit Weynand ⁹

Julius Beer ¹⁰

Daniel Schnepf ¹⁰

Annette Ohnemus ¹⁰

Isabel Remory ¹¹

Caroline F H Foo ⁴

Rana Abdelnabi ^{4, 5}

Piet Maes ¹²

Suzanne J. F. Kaptein ^{4, 5}

Joana Rocha-Pereira ^{4, 5}

Dirk Jochmans ^{4, 5}

Leen Delang ^{4, 5}

Frank Peelman ^{1, 13}

W B Offensperger ^{10, 14}

Martin Schwemmle ^{10, 14}

Nick Devoogdt ¹¹

Dominique Tersago ¹⁵

Massimiliano Germani ¹⁶

James T Heads ¹⁶

Alistair Henry ¹⁶

Andrew Popplewell ¹⁶

Mark Ellis ¹⁶

Kevin Brady ¹⁶

Alison Turner ¹⁶

Bruno Dombrecht ³

Catelijne Stortelers ³

Johan Neyts ^{4, 5, 7}

Nico Callewaert ^{1, 2}

Xavier Saelens ^{1, 2}

Hide authors affiliations Show authors affiliations: 16 affiliations

VIB-UGent Center for Medical Biotechnology, VIB, Technologiepark-Zwijnaarde 75, 9052 Ghent, Belgium. |

Department of Biochemistry and Microbiology, Ghent University, Technologiepark-Zwijnaarde 75, 9052 Ghent, Belgium. |

VIB Discovery Sciences, Technologiepark-Zwijnaarde 104B, 9052 Ghent, Belgium. |

⁴

KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute, 3000 Leuven, Belgium. |

⁵

GVN, Global Virus Network, Baltimore, MD 21201, USA. |

⁶

KU Leuven Department of Imaging and Pathology, Biomedical MRI and MoSAIC, 3000 Leuven, Belgium. |

⁷

KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Molecular Vaccinology and Vaccine Discovery Group, 3000 Leuven, Belgium. |

⁸

KU Leuven Department of Microbiology, Immunology and Transplantation, Translational Platform Virology and Chemotherapy (TPVC), Rega Institute, 3000 Leuven, Belgium. |

⁹

KU Leuven Department of Imaging and Pathology, Division of Translational Cell and Tissue Research, Translational Cell and Tissue Research, 3000 Leuven, Belgium. |

¹⁰

Institute of Virology, Medical Center University Freiburg, 79104 Freiburg, Germany. |

¹¹

Department of Medical Imaging, In vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium. |

¹²

KU Leuven, Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical and Epidemiological Virology, Rega Institute, 3000 Leuven, Belgium. |

¹³

Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium. |

¹⁴

Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany. |

¹⁵

ExeVir, Rijvisschestraat 120, 9052 Ghent, Belgium. |

¹⁶

UCB Celltech, Slough, SL1 3WE, UK. |

Publication type: Journal Article

Publication date: 2021-11-24

American Association for the Advancement of Science (AAAS)

Journal: Science Translational Medicine

Quartile SCImago

Quartile WOS

Impact factor: 17.1

ISSN: 19466234, 19466242

DOI: 10.1126/scitranslmed.abi7826

Copy DOI

General Medicine

Abstract

A heavy chain–only antibody drug with broad SARS coronavirus neutralizing activity protects mice and hamsters.

By date By citations

Top-30

Citations by journals

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Frontiers in Immunology	Frontiers in Immunology, 3, 6.82% Frontiers in Immunology 3 publications, 6.82%
Nature Communications	Nature Communications, 3, 6.82% Nature Communications 3 publications, 6.82%
Viruses	Viruses, 2, 4.55% Viruses 2 publications, 4.55%
Antiviral Research	Antiviral Research, 2, 4.55% Antiviral Research 2 publications, 4.55%
Journal of General Virology	Journal of General Virology, 1, 2.27% Journal of General Virology 1 publication, 2.27%
Nanomaterials	Nanomaterials, 1, 2.27% Nanomaterials 1 publication, 2.27%
Frontiers in Cardiovascular Medicine	Frontiers in Cardiovascular Medicine, 1, 2.27% Frontiers in Cardiovascular Medicine 1 publication, 2.27%
Frontiers in Drug Discovery	Frontiers in Drug Discovery, 1, 2.27% Frontiers in Drug Discovery 1 publication, 2.27%
Scientific Reports	Scientific Reports, 1, 2.27% Scientific Reports 1 publication, 2.27%
Biochemical Pharmacology	Biochemical Pharmacology, 1, 2.27% Biochemical Pharmacology 1 publication, 2.27%
Molecular Aspects of Medicine	Molecular Aspects of Medicine, 1, 2.27% Molecular Aspects of Medicine 1 publication, 2.27%
PLoS ONE	PLoS ONE, 1, 2.27% PLoS ONE 1 publication, 2.27%
Small Methods	Small Methods, 1, 2.27% Small Methods 1 publication, 2.27%
FEBS Open Bio	FEBS Open Bio, 1, 2.27% FEBS Open Bio 1 publication, 2.27%
Antibodies	Antibodies, 1, 2.27% Antibodies 1 publication, 2.27%
mAbs	mAbs, 1, 2.27% mAbs 1 publication, 2.27%
EMBO Reports	EMBO Reports, 1, 2.27% EMBO Reports 1 publication, 2.27%
Journal of Experimental Medicine	Journal of Experimental Medicine, 1, 2.27% Journal of Experimental Medicine 1 publication, 2.27%
iScience	iScience, 1, 2.27% iScience 1 publication, 2.27%
Journal of Biomolecular Structure and Dynamics	Journal of Biomolecular Structure and Dynamics, 1, 2.27% Journal of Biomolecular Structure and Dynamics 1 publication, 2.27%
mBio	mBio, 1, 2.27% mBio 1 publication, 2.27%
EBioMedicine	EBioMedicine, 1, 2.27% EBioMedicine 1 publication, 2.27%
Journal of Nanobiotechnology	Journal of Nanobiotechnology, 1, 2.27% Journal of Nanobiotechnology 1 publication, 2.27%
Biomedicine and Pharmacotherapy	Biomedicine and Pharmacotherapy, 1, 2.27% Biomedicine and Pharmacotherapy 1 publication, 2.27%
Russian Chemical Reviews	Russian Chemical Reviews, 1, 2.27% Russian Chemical Reviews 1 publication, 2.27%
PLoS Pathogens	PLoS Pathogens, 1, 2.27% PLoS Pathogens 1 publication, 2.27%
International Journal of Biological Macromolecules	International Journal of Biological Macromolecules, 1, 2.27% International Journal of Biological Macromolecules 1 publication, 2.27%
	1 2 3

Citations by publishers

	1 2 3 4 5 6 7 8
Elsevier	Elsevier, 8, 18.18% Elsevier 8 publications, 18.18%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 8, 18.18% Cold Spring Harbor Laboratory 8 publications, 18.18%
Frontiers Media S.A.	Frontiers Media S.A., 5, 11.36% Frontiers Media S.A. 5 publications, 11.36%
Springer Nature	Springer Nature, 5, 11.36% Springer Nature 5 publications, 11.36%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 4, 9.09% Multidisciplinary Digital Publishing Institute (MDPI) 4 publications, 9.09%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 2, 4.55% Public Library of Science (PLoS) 2 publications, 4.55%
Wiley	Wiley, 2, 4.55% Wiley 2 publications, 4.55%
Taylor & Francis	Taylor & Francis, 2, 4.55% Taylor & Francis 2 publications, 4.55%
Microbiology Society	Microbiology Society, 1, 2.27% Microbiology Society 1 publication, 2.27%
EMBO press	EMBO press, 1, 2.27% EMBO press 1 publication, 2.27%
Rockefeller University Press	Rockefeller University Press, 1, 2.27% Rockefeller University Press 1 publication, 2.27%
American Society for Microbiology	American Society for Microbiology, 1, 2.27% American Society for Microbiology 1 publication, 2.27%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 2.27% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 2.27%
	1 2 3 4 5 6 7 8

We do not take into account publications without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

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Schepens B. et al. An affinity-enhanced, broadly neutralizing heavy chain–only antibody protects against SARS-CoV-2 infection in animal models // Science Translational Medicine. 2021. Vol. 13. No. 621.

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RIS |

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RIS Copy

TY - JOUR

DO - 10.1126/scitranslmed.abi7826

UR - https://doi.org/10.1126/scitranslmed.abi7826

TI - An affinity-enhanced, broadly neutralizing heavy chain–only antibody protects against SARS-CoV-2 infection in animal models

T2 - Science Translational Medicine

AU - Schepens, B.

AU - Van Schie, Loes

AU - Nerinckx, Wim

AU - Roose, K.

AU - Van Breedam, Wander

AU - Fijałkowska, Daria

AU - Devos, Simon

AU - Weyts, Wannes

AU - De Cae, Sieglinde

AU - Vanmarcke, Sandrine

AU - Lonigro, Chiara

AU - Eeckhaut, Hannah

AU - Van Herpe, Dries

AU - Borloo, Jimmy

AU - Oliveira, Ana Filipa

AU - Catani, J. P.

AU - Creytens, Sarah

AU - De Vlieger, Dorien

AU - Michielsen, Gitte

AU - Marchan, Jackeline Cecilia Zavala

AU - Moschonas, George D

AU - Rossey, Iebe

AU - Sedeyn, Koen

AU - Van Hecke, Annelies

AU - Zhang, Xin

AU - Langendries, Lana

AU - Jacobs, Sofie

AU - Ter Horst, Sebastiaan

AU - Seldeslachts, Laura

AU - Liesenborghs, Laurens

AU - Boudewijns, Robbert

AU - Thibaut, Hendrik Jan

AU - Dallmeier, Kai

AU - Velde, Greetje Vande

AU - Weynand, Birgit

AU - Beer, Julius

AU - Schnepf, Daniel

AU - Ohnemus, Annette

AU - Remory, Isabel

AU - Foo, Caroline F H

AU - Abdelnabi, Rana

AU - Maes, Piet

AU - Kaptein, Suzanne J. F.

AU - Rocha-Pereira, Joana

AU - Jochmans, Dirk

AU - Delang, Leen

AU - Peelman, Frank

AU - Offensperger, W B

AU - Schwemmle, Martin

AU - Devoogdt, Nick

AU - Tersago, Dominique

AU - Germani, Massimiliano

AU - Heads, James T

AU - Henry, Alistair

AU - Popplewell, Andrew

AU - Ellis, Mark

AU - Brady, Kevin

AU - Turner, Alison

AU - Dombrecht, Bruno

AU - Stortelers, Catelijne

AU - Neyts, Johan

AU - Callewaert, Nico

AU - Saelens, Xavier

PY - 2021

DA - 2021/11/24 00:00:00

PB - American Association for the Advancement of Science (AAAS)

IS - 621

VL - 13

SN - 1946-6234

SN - 1946-6242

ER -

BibTex

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BibTex Copy

@article{2021_Schepens,

author = {B. Schepens and Loes Van Schie and Wim Nerinckx and K. Roose and Wander Van Breedam and Daria Fijałkowska and Simon Devos and Wannes Weyts and Sieglinde De Cae and Sandrine Vanmarcke and Chiara Lonigro and Hannah Eeckhaut and Dries Van Herpe and Jimmy Borloo and Ana Filipa Oliveira and J. P. Catani and Sarah Creytens and Dorien De Vlieger and Gitte Michielsen and Jackeline Cecilia Zavala Marchan and George D Moschonas and Iebe Rossey and Koen Sedeyn and Annelies Van Hecke and Xin Zhang and Lana Langendries and Sofie Jacobs and Sebastiaan Ter Horst and Laura Seldeslachts and Laurens Liesenborghs and Robbert Boudewijns and Hendrik Jan Thibaut and Kai Dallmeier and Greetje Vande Velde and Birgit Weynand and Julius Beer and Daniel Schnepf and Annette Ohnemus and Isabel Remory and Caroline F H Foo and Rana Abdelnabi and Piet Maes and Suzanne J. F. Kaptein and Joana Rocha-Pereira and Dirk Jochmans and Leen Delang and Frank Peelman and W B Offensperger and Martin Schwemmle and Nick Devoogdt and Dominique Tersago and Massimiliano Germani and James T Heads and Alistair Henry and Andrew Popplewell and Mark Ellis and Kevin Brady and Alison Turner and Bruno Dombrecht and Catelijne Stortelers and Johan Neyts and Nico Callewaert and Xavier Saelens},

title = {An affinity-enhanced, broadly neutralizing heavy chain–only antibody protects against SARS-CoV-2 infection in animal models},

journal = {Science Translational Medicine},

year = {2021},

volume = {13},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {nov},

url = {https://doi.org/10.1126/scitranslmed.abi7826},

number = {621},

doi = {10.1126/scitranslmed.abi7826}

}

Found error?

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science Translational Medicine

Quartile SCImago

Quartile WOS

Impact factor

17.1

ISSN

19466234 (Print)
19466242 (Electronic)