Open Access

American Association for the Advancement of Science (AAAS)

Science advances

, volume 7 , issue 22

Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses

Sham Nambulli ^{1, 2}

Yufei Xiang ³

Natasha L. Tilston-Lunel ^{1, 2}

Linda J. Rennick ^{1, 2}

Zhe Sang ^{3, 4}

William B. Klimstra ^{1, 2, 5}

Douglas Reed ^{1, 5}

Nicholas A. Crossland ^{6, 7}

Yi Shi ^{3, 4}

W. Paul Duprex ^{1, 2}

Hide authors affiliations Show authors affiliations: 7 affiliations

Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA. |

Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA. |

Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA. |

⁴

University of Pittsburgh–Carnegie Mellon University Program in Computational Biology, Pittsburgh, PA, USA. |

⁵

Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA. |

⁶

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA. |

⁷

National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA. |

Publication type: Journal Article

Publication date: 2021-05-28

American Association for the Advancement of Science (AAAS)

Science advances

scimago Q1

wos Q1

SJR: 4.324

CiteScore: 19.6

Impact factor: 12.5

ISSN: 23752548

DOI: 10.1126/sciadv.abh0319

Copy DOI

PubMed ID: 34039613

Multidisciplinary

Abstract

Aerosol delivery of an ultrapotent nanobody efficiently prevents and treats SARS-CoV-2 infection.

Found

1 citation

Puccetti Matteo

35 publications, 1 273 citations

h-index: 17

University of Perugia

1 citation

Hossain M.

🥼 🤝

PhD in Engineering

282 publications, 11 909 citations, 628 reviews

h-index: 59

Bangladesh Atomic Energy Commission

1 citation

Shihab Uddin

🥼 🤝

PhD in Biological/biomedical sciences, senior lecturer, associate member of the Bangladesh Academy of Sciences

28 publications, 512 citations, 3 reviews

h-index: 12

King Fahd University of Petroleum and Minerals

Massachusetts Institute of Technology

Kyushu University

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GOST Copy

Nambulli S. et al. Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses // Science advances. 2021. Vol. 7. No. 22.

GOST all authors (up to 50) Copy

Nambulli S., Xiang Y., Tilston-Lunel N. L., Rennick L. J., Sang Z., Klimstra W. B., Reed D., Crossland N. A., Shi Y., Duprex W. P. Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses // Science advances. 2021. Vol. 7. No. 22.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1126/sciadv.abh0319

UR - https://doi.org/10.1126/sciadv.abh0319

TI - Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses

T2 - Science advances

AU - Nambulli, Sham

AU - Xiang, Yufei

AU - Tilston-Lunel, Natasha L.

AU - Rennick, Linda J.

AU - Sang, Zhe

AU - Klimstra, William B.

AU - Reed, Douglas

AU - Crossland, Nicholas A.

AU - Shi, Yi

AU - Duprex, W. Paul

PY - 2021

DA - 2021/05/28

PB - American Association for the Advancement of Science (AAAS)

IS - 22

VL - 7

PMID - 34039613

SN - 2375-2548

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2021_Nambulli,

author = {Sham Nambulli and Yufei Xiang and Natasha L. Tilston-Lunel and Linda J. Rennick and Zhe Sang and William B. Klimstra and Douglas Reed and Nicholas A. Crossland and Yi Shi and W. Paul Duprex},

title = {Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses},

journal = {Science advances},

year = {2021},

volume = {7},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {may},

url = {https://doi.org/10.1126/sciadv.abh0319},

number = {22},

doi = {10.1126/sciadv.abh0319}

}

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science advances

scimago Q1

wos Q1

SJR

4.324

CiteScore

19.6

Impact factor

12.5

ISSN

23752548 (Electronic)