Open Access

Science, volume 321, issue 5897, pages 1834-1837

Antigen Recognition by Variable Lymphocyte Receptors

Byung Woo Han ^{1, 2, 3}

Brantley R. Herrin ^{1, 2, 3}

Max D. Cooper ^{1, 2, 3}

IAN A. WILSON ^{1, 2, 3}

Hide authors affiliations Show authors affiliations: 3 affiliations

Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037, USA. |

Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, CA 92037, USA. |

Emory Vaccine Center and Department of Pathology and Laboratory Medicine, Emory University, 1462 Clifton Road NE, Atlanta, GA 30322, USA. |

Publication type: Journal Article

Publication date: 2008-09-26

American Association for the Advancement of Science (AAAS)

Journal: Science

Quartile SCImago

Quartile WOS

Impact factor: 56.9

ISSN: 00368075, 10959203

DOI: 10.1126/science.1162484

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Multidisciplinary

Abstract

Variable lymphocyte receptors (VLRs) rather than antibodies play the primary role in recognition of antigens in the adaptive immune system of jawless vertebrates. Combinatorial assembly of leucine-rich repeat (LRR) gene segments achieves the required repertoire for antigen recognition. We have determined a crystal structure for a VLR-antigen complex, VLR RBC36 in complex with the H-antigen trisaccharide from human blood type O erythrocytes, at 1.67 angstrom resolution. RBC36 binds the H-trisaccharide on the concave surface of the LRR modules of the solenoid structure where three key hydrophilic residues, multiple van der Waals interactions, and the highly variable insert of the carboxyl-terminal LRR module determine antigen recognition and specificity. The concave surface assembled from the most highly variable regions of the LRRs, along with diversity in the sequence and length of the highly variable insert, can account for the recognition of diverse antigens by VLRs.

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Citations by journals

	1 2 3 4 5 6 7 8
Proceedings of the National Academy of Sciences of the United States of America	Proceedings of the National Academy of Sciences of the United States of America, 8, 5.23% Proceedings of the National Academy of Sciences of the United States of America 8 publications, 5.23%
Fish and Shellfish Immunology	Fish and Shellfish Immunology, 7, 4.58% Fish and Shellfish Immunology 7 publications, 4.58%
Journal of Immunology	Journal of Immunology, 6, 3.92% Journal of Immunology 6 publications, 3.92%
Scientific Reports	Scientific Reports, 4, 2.61% Scientific Reports 4 publications, 2.61%
Journal of Biological Chemistry	Journal of Biological Chemistry, 3, 1.96% Journal of Biological Chemistry 3 publications, 1.96%
Structure	Structure, 3, 1.96% Structure 3 publications, 1.96%
ACS Chemical Biology	ACS Chemical Biology, 3, 1.96% ACS Chemical Biology 3 publications, 1.96%
Methods in Molecular Biology	Methods in Molecular Biology, 3, 1.96% Methods in Molecular Biology 3 publications, 1.96%
Annual Review of Immunology	Annual Review of Immunology, 3, 1.96% Annual Review of Immunology 3 publications, 1.96%
Oncotarget	Oncotarget, 2, 1.31% Oncotarget 2 publications, 1.31%
Frontiers in Immunology	Frontiers in Immunology, 2, 1.31% Frontiers in Immunology 2 publications, 1.31%
Acta Biochimica et Biophysica Sinica	Acta Biochimica et Biophysica Sinica, 2, 1.31% Acta Biochimica et Biophysica Sinica 2 publications, 1.31%
Communications Biology	Communications Biology, 2, 1.31% Communications Biology 2 publications, 1.31%
Nature Reviews Immunology	Nature Reviews Immunology, 2, 1.31% Nature Reviews Immunology 2 publications, 1.31%
PLoS ONE	PLoS ONE, 2, 1.31% PLoS ONE 2 publications, 1.31%
Current Opinion in Immunology	Current Opinion in Immunology, 2, 1.31% Current Opinion in Immunology 2 publications, 1.31%
Biochimica et Biophysica Acta - Proteins and Proteomics	Biochimica et Biophysica Acta - Proteins and Proteomics, 2, 1.31% Biochimica et Biophysica Acta - Proteins and Proteomics 2 publications, 1.31%
Journal of Immunological Methods	Journal of Immunological Methods, 2, 1.31% Journal of Immunological Methods 2 publications, 1.31%
Developmental and Comparative Immunology	Developmental and Comparative Immunology, 2, 1.31% Developmental and Comparative Immunology 2 publications, 1.31%
Molecular Immunology	Molecular Immunology, 2, 1.31% Molecular Immunology 2 publications, 1.31%
European Journal of Immunology	European Journal of Immunology, 2, 1.31% European Journal of Immunology 2 publications, 1.31%
Advances in Immunology	Advances in Immunology, 2, 1.31% Advances in Immunology 2 publications, 1.31%
Advances in Experimental Medicine and Biology	Advances in Experimental Medicine and Biology, 2, 1.31% Advances in Experimental Medicine and Biology 2 publications, 1.31%
Science advances	Science advances, 2, 1.31% Science advances 2 publications, 1.31%
Physical Review B	Physical Review B, 1, 0.65% Physical Review B 1 publication, 0.65%
JCI insight	JCI insight, 1, 0.65% JCI insight 1 publication, 0.65%
Acta Crystallographica Section F Structural Biology and Crystallization Communications	Acta Crystallographica Section F Structural Biology and Crystallization Communications, 1, 0.65% Acta Crystallographica Section F Structural Biology and Crystallization Communications 1 publication, 0.65%
Acta Crystallographica Section D: Structural Biology	Acta Crystallographica Section D: Structural Biology, 1, 0.65% Acta Crystallographica Section D: Structural Biology 1 publication, 0.65%
Viral Immunology	Viral Immunology, 1, 0.65% Viral Immunology 1 publication, 0.65%
	1 2 3 4 5 6 7 8

Citations by publishers

	5 10 15 20 25 30 35 40 45
Elsevier	Elsevier, 42, 27.45% Elsevier 42 publications, 27.45%
Springer Nature	Springer Nature, 24, 15.69% Springer Nature 24 publications, 15.69%
Wiley	Wiley, 13, 8.5% Wiley 13 publications, 8.5%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 8, 5.23% Proceedings of the National Academy of Sciences (PNAS) 8 publications, 5.23%
Annual Reviews	Annual Reviews, 7, 4.58% Annual Reviews 7 publications, 4.58%
The American Association of Immunologists	The American Association of Immunologists, 6, 3.92% The American Association of Immunologists 6 publications, 3.92%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 5, 3.27% Multidisciplinary Digital Publishing Institute (MDPI) 5 publications, 3.27%
Oxford University Press	Oxford University Press, 5, 3.27% Oxford University Press 5 publications, 3.27%
American Chemical Society (ACS)	American Chemical Society (ACS), 4, 2.61% American Chemical Society (ACS) 4 publications, 2.61%
Frontiers Media S.A.	Frontiers Media S.A., 3, 1.96% Frontiers Media S.A. 3 publications, 1.96%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 3, 1.96% American Society for Biochemistry and Molecular Biology 3 publications, 1.96%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 3, 1.96% American Association for the Advancement of Science (AAAS) 3 publications, 1.96%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 3, 1.96% Cold Spring Harbor Laboratory 3 publications, 1.96%
Impact Journals	Impact Journals, 2, 1.31% Impact Journals 2 publications, 1.31%
International Union of Crystallography (IUCr)	International Union of Crystallography (IUCr), 2, 1.31% International Union of Crystallography (IUCr) 2 publications, 1.31%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 2, 1.31% Public Library of Science (PLoS) 2 publications, 1.31%
American Physical Society (APS)	American Physical Society (APS), 1, 0.65% American Physical Society (APS) 1 publication, 0.65%
American Society for Clinical Investigation	American Society for Clinical Investigation, 1, 0.65% American Society for Clinical Investigation 1 publication, 0.65%
Mary Ann Liebert	Mary Ann Liebert, 1, 0.65% Mary Ann Liebert 1 publication, 0.65%
Wolters Kluwer Health	Wolters Kluwer Health, 1, 0.65% Wolters Kluwer Health 1 publication, 0.65%
China Science Publishing & Media	China Science Publishing & Media, 1, 0.65% China Science Publishing & Media 1 publication, 0.65%
Science in China Press	Science in China Press, 1, 0.65% Science in China Press 1 publication, 0.65%
Federation of American Societies for Experimental Biology (FASEB)	Federation of American Societies for Experimental Biology (FASEB), 1, 0.65% Federation of American Societies for Experimental Biology (FASEB) 1 publication, 0.65%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 0.65% Royal Society of Chemistry (RSC) 1 publication, 0.65%
Pleiades Publishing	Pleiades Publishing, 1, 0.65% Pleiades Publishing 1 publication, 0.65%
American Society of Plant Biologists	American Society of Plant Biologists, 1, 0.65% American Society of Plant Biologists 1 publication, 0.65%
EMBO press	EMBO press, 1, 0.65% EMBO press 1 publication, 0.65%
Cambridge University Press	Cambridge University Press, 1, 0.65% Cambridge University Press 1 publication, 0.65%
Walter de Gruyter	Walter de Gruyter, 1, 0.65% Walter de Gruyter 1 publication, 0.65%
	5 10 15 20 25 30 35 40 45

We do not take into account publications without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

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GOST Copy

Han B. W. et al. Antigen Recognition by Variable Lymphocyte Receptors // Science. 2008. Vol. 321. No. 5897. pp. 1834-1837.

GOST all authors (up to 50) Copy

Han B. W., Herrin B. R., Cooper M. D., WILSON I. A. Antigen Recognition by Variable Lymphocyte Receptors // Science. 2008. Vol. 321. No. 5897. pp. 1834-1837.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1126/science.1162484

UR - https://doi.org/10.1126/science.1162484

TI - Antigen Recognition by Variable Lymphocyte Receptors

T2 - Science

AU - Han, Byung Woo

AU - Herrin, Brantley R.

AU - Cooper, Max D.

AU - WILSON, IAN A.

PY - 2008

DA - 2008/09/26 00:00:00

PB - American Association for the Advancement of Science (AAAS)

SP - 1834-1837

IS - 5897

VL - 321

SN - 0036-8075

SN - 1095-9203

ER -

BibTex |

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BibTex Copy

@article{2008_Han,

author = {Byung Woo Han and Brantley R. Herrin and Max D. Cooper and IAN A. WILSON},

title = {Antigen Recognition by Variable Lymphocyte Receptors},

journal = {Science},

year = {2008},

volume = {321},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {sep},

url = {https://doi.org/10.1126/science.1162484},

number = {5897},

pages = {1834--1837},

doi = {10.1126/science.1162484}

}

MLA

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MLA Copy

Han, Byung Woo, et al. “Antigen Recognition by Variable Lymphocyte Receptors.” Science, vol. 321, no. 5897, Sep. 2008, pp. 1834-1837. https://doi.org/10.1126/science.1162484.

Found error?

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science

Quartile SCImago

Quartile WOS

Impact factor

56.9

ISSN

00368075 (Print)
10959203 (Electronic)