American Association for the Advancement of Science (AAAS)

Science Translational Medicine

, volume 13 , issue 621

An affinity-enhanced, broadly neutralizing heavy chain–only antibody protects against SARS-CoV-2 infection in animal models

B. Schepens ^{1, 2}

Loes Van Schie ^{1, 2}

Wim Nerinckx ^{1, 2}

K. Roose ^{1, 2}

Wander Van Breedam ^{1, 2}

Daria Fijałkowska ^{1, 2}

Simon Devos ^{1, 2}

Wannes Weyts ^{1, 2}

Sieglinde De Cae ^{1, 2}

Sandrine Vanmarcke ^{1, 2}

Chiara Lonigro ^{1, 2}

Hannah Eeckhaut ^{1, 2}

Dries Van Herpe ^{1, 2}

Jimmy Borloo ³

Ana Filipa Oliveira ³

J. P. Catani ^{1, 2}

Sarah Creytens ^{1, 2}

Dorien De Vlieger ^{1, 2}

Gitte Michielsen ^{1, 2}

Jackeline Cecilia Zavala Marchan ^{1, 2}

George D Moschonas ^{1, 2}

Iebe Rossey ^{1, 2}

Koen Sedeyn ^{1, 2}

Annelies Van Hecke ^{1, 2}

Xin Zhang ^{4, 5}

Lana Langendries ^{4, 5}

Sofie Jacobs ^{4, 5}

Sebastiaan Ter Horst ^{4, 5}

Laura Seldeslachts ⁶

Laurens Liesenborghs ^{4, 5}

Robbert Boudewijns ^{4, 5, 7}

Hendrik Jan Thibaut ^{4, 7, 8}

Kai Dallmeier ^{4, 5, 7}

Greetje Vande Velde ⁶

Birgit Weynand ⁹

Julius Beer ¹⁰

Daniel Schnepf ¹⁰

Annette Ohnemus ¹⁰

Isabel Remory ¹¹

Caroline F H Foo ⁴

Rana Abdelnabi ^{4, 5}

Piet Maes ¹²

Suzanne J. F. Kaptein ^{4, 5}

Joana Rocha-Pereira ^{4, 5}

Dirk Jochmans ^{4, 5}

Leen Delang ^{4, 5}

Frank Peelman ^{1, 13}

W B Offensperger ^{10, 14}

Martin Schwemmle ^{10, 14}

Nick Devoogdt ¹¹

Dominique Tersago ¹⁵

Massimiliano Germani ¹⁶

James T Heads ¹⁶

Alistair Henry ¹⁶

Andrew Popplewell ¹⁶

Mark Ellis ¹⁶

Kevin Brady ¹⁶

Alison Turner ¹⁶

Bruno Dombrecht ³

Catelijne Stortelers ³

Johan Neyts ^{4, 5, 7}

Nico Callewaert ^{1, 2}

Xavier Saelens ^{1, 2}

Hide authors affiliations Show authors affiliations: 16 affiliations

VIB-UGent Center for Medical Biotechnology, VIB, Technologiepark-Zwijnaarde 75, 9052 Ghent, Belgium. |

Department of Biochemistry and Microbiology, Ghent University, Technologiepark-Zwijnaarde 75, 9052 Ghent, Belgium. |

VIB Discovery Sciences, Technologiepark-Zwijnaarde 104B, 9052 Ghent, Belgium. |

⁴

KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute, 3000 Leuven, Belgium. |

⁵

GVN, Global Virus Network, Baltimore, MD 21201, USA. |

⁶

KU Leuven Department of Imaging and Pathology, Biomedical MRI and MoSAIC, 3000 Leuven, Belgium. |

⁷

KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Molecular Vaccinology and Vaccine Discovery Group, 3000 Leuven, Belgium. |

⁸

KU Leuven Department of Microbiology, Immunology and Transplantation, Translational Platform Virology and Chemotherapy (TPVC), Rega Institute, 3000 Leuven, Belgium. |

⁹

KU Leuven Department of Imaging and Pathology, Division of Translational Cell and Tissue Research, Translational Cell and Tissue Research, 3000 Leuven, Belgium. |

¹⁰

Institute of Virology, Medical Center University Freiburg, 79104 Freiburg, Germany. |

¹¹

Department of Medical Imaging, In vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium. |

¹²

KU Leuven, Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical and Epidemiological Virology, Rega Institute, 3000 Leuven, Belgium. |

¹³

Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium. |

¹⁴

Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany. |

¹⁵

ExeVir, Rijvisschestraat 120, 9052 Ghent, Belgium. |

¹⁶

UCB Celltech, Slough, SL1 3WE, UK. |

Publication type: Journal Article

Publication date: 2021-11-24

American Association for the Advancement of Science (AAAS)

Science Translational Medicine

scimago Q1

wos Q1

SJR: 6.722

CiteScore: 27.9

Impact factor: 14.6

ISSN: 19466234, 19466242

DOI: 10.1126/scitranslmed.abi7826

Copy DOI

PubMed ID: 34609205

General Medicine

Abstract

A heavy chain–only antibody drug with broad SARS coronavirus neutralizing activity protects mice and hamsters.

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Schepens B. et al. An affinity-enhanced, broadly neutralizing heavy chain–only antibody protects against SARS-CoV-2 infection in animal models // Science Translational Medicine. 2021. Vol. 13. No. 621.

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@article{2021_Schepens,

author = {B. Schepens and Loes Van Schie and Wim Nerinckx and K. Roose and Wander Van Breedam and Daria Fijałkowska and Simon Devos and Wannes Weyts and Sieglinde De Cae and Sandrine Vanmarcke and Chiara Lonigro and Hannah Eeckhaut and Dries Van Herpe and Jimmy Borloo and Ana Filipa Oliveira and J. P. Catani and Sarah Creytens and Dorien De Vlieger and Gitte Michielsen and Jackeline Cecilia Zavala Marchan and George D Moschonas and Iebe Rossey and Koen Sedeyn and Annelies Van Hecke and Xin Zhang and Lana Langendries and Sofie Jacobs and Sebastiaan Ter Horst and Laura Seldeslachts and Laurens Liesenborghs and Robbert Boudewijns and Hendrik Jan Thibaut and Kai Dallmeier and Greetje Vande Velde and Birgit Weynand and Julius Beer and Daniel Schnepf and Annette Ohnemus and Isabel Remory and Caroline F H Foo and Rana Abdelnabi and Piet Maes and Suzanne J. F. Kaptein and Joana Rocha-Pereira and Dirk Jochmans and Leen Delang and Frank Peelman and W B Offensperger and Martin Schwemmle and Nick Devoogdt and others},

title = {An affinity-enhanced, broadly neutralizing heavy chain–only antibody protects against SARS-CoV-2 infection in animal models},

journal = {Science Translational Medicine},

year = {2021},

volume = {13},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {nov},

url = {https://doi.org/10.1126/scitranslmed.abi7826},

number = {621},

doi = {10.1126/scitranslmed.abi7826}

}

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science Translational Medicine

scimago Q1

wos Q1

SJR

6.722

CiteScore

27.9

Impact factor

14.6

ISSN

19466234 (Print)

19466242 (Electronic)