Open Access
Autocrine-based selection of ligands for personalized CAR-T therapy of lymphoma
Oleg V Markov
2
,
Ivan V. Chernikov
2
,
Hongkai Zhang
3, 4
,
Teresa Jones
3
,
Alexandra V Senkova
2
,
Elena L. Chernolovskaya
2
,
Marina A Zenkova
2
,
Roman S Kalinin
1
,
Maria P Rubtsova
5
,
Dmitry D Genkin
7
,
Alexey A. Belogurov
1
,
Jia Xie
3
,
A. G. Gabibov
1
,
6
Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus.
|
7
OJSC Pharmsynthez, 197110 St. Petersburg, Russian Federation.
|
Publication type: Journal Article
Publication date: 2018-11-02
scimago Q1
wos Q1
SJR: 4.324
CiteScore: 19.6
Impact factor: 12.5
ISSN: 23752548
PubMed ID:
30443597
Multidisciplinary
Abstract
We report the development of a novel platform to enhance the efficacy and safety of follicular lymphoma (FL) treatment. Since lymphoma is a clonal malignancy of a diversity system, every tumor has a different antibody on its cell surface. Combinatorial autocrine-based selection is used to rapidly identify specific ligands for these B cell receptors on the surface of FL tumor cells. The selected ligands are used in a chimeric antigen receptor T cell (CAR-T) format for redirection of human cytotoxic T lymphocytes. Essentially, the format is the inverse of the usual CAR-T protocol. Instead of being a guide molecule, the antibody itself is the target. Thus, these studies raise the possibility of personalized treatment of lymphomas using a private antibody binding ligand that can be obtained in a few weeks.
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Total citations:
24
Citations from 2024:
4
(16.67%)
Cite this
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BibTex |
MLA
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GOST
Copy
Stepanov G. V. et al. Autocrine-based selection of ligands for personalized CAR-T therapy of lymphoma // Science advances. 2018. Vol. 4. No. 11. p. eaau4580.
GOST all authors (up to 50)
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Stepanov G. V., Markov O. V., Chernikov I. V., Gladkikh D. V., Zhang H., Jones T., Senkova A. V., Chernolovskaya E. L., Zenkova M. A., Kalinin R. S., Rubtsova M. P., Meleshko A. N., Genkin D. D., Belogurov A. A., Xie J., Gabibov A. G., Lerner R. A. Autocrine-based selection of ligands for personalized CAR-T therapy of lymphoma // Science advances. 2018. Vol. 4. No. 11. p. eaau4580.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1126/sciadv.aau4580
UR - https://doi.org/10.1126/sciadv.aau4580
TI - Autocrine-based selection of ligands for personalized CAR-T therapy of lymphoma
T2 - Science advances
AU - Stepanov, Gennady V
AU - Markov, Oleg V
AU - Chernikov, Ivan V.
AU - Gladkikh, Daniil V.
AU - Zhang, Hongkai
AU - Jones, Teresa
AU - Senkova, Alexandra V
AU - Chernolovskaya, Elena L.
AU - Zenkova, Marina A
AU - Kalinin, Roman S
AU - Rubtsova, Maria P
AU - Meleshko, Alexander N
AU - Genkin, Dmitry D
AU - Belogurov, Alexey A.
AU - Xie, Jia
AU - Gabibov, A. G.
AU - Lerner, R A
PY - 2018
DA - 2018/11/02
PB - American Association for the Advancement of Science (AAAS)
SP - eaau4580
IS - 11
VL - 4
PMID - 30443597
SN - 2375-2548
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Stepanov,
author = {Gennady V Stepanov and Oleg V Markov and Ivan V. Chernikov and Daniil V. Gladkikh and Hongkai Zhang and Teresa Jones and Alexandra V Senkova and Elena L. Chernolovskaya and Marina A Zenkova and Roman S Kalinin and Maria P Rubtsova and Alexander N Meleshko and Dmitry D Genkin and Alexey A. Belogurov and Jia Xie and A. G. Gabibov and R A Lerner},
title = {Autocrine-based selection of ligands for personalized CAR-T therapy of lymphoma},
journal = {Science advances},
year = {2018},
volume = {4},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {nov},
url = {https://doi.org/10.1126/sciadv.aau4580},
number = {11},
pages = {eaau4580},
doi = {10.1126/sciadv.aau4580}
}
Cite this
MLA
Copy
Stepanov, Gennady V., et al. “Autocrine-based selection of ligands for personalized CAR-T therapy of lymphoma.” Science advances, vol. 4, no. 11, Nov. 2018, p. eaau4580. https://doi.org/10.1126/sciadv.aau4580.