Open Access

Science advances, volume 8, issue 27

A handheld intelligent single-molecule binary bioelectronic system for fast and reliable immunometric point-of-care testing

Eleonora Macchia ^{1, 2}

Zsolt M Kovács Vajna ³

Daniela Loconsole ⁴

Lucia Sarcina ⁵

Massimiliano Redolfi ⁶

Maria Chironna ⁴

Fabrizio Torricelli ³

L. Torsi ⁵

Hide authors affiliations Show authors affiliations: 6 affiliations

Dipartimento di Farmacia-Scienze del Farmaco, Universit. degli Studi di Bari “Aldo Moro,” 70125 Bari, Italy. |

Faculty of Science and Engineering, Åbo Akademi University, 20500 Turku, Finland. |

Dipartimento di Ingegneria dell’Informazione, Università degli Studi di Brescia, 25123 Brescia, Italy. |

⁴

Dipartimento di Scienze Biomediche e Oncologia Umana, Università degli Studi di Bari “Aldo Moro,” 70125 Bari, Italy. |

⁵

Dipartimento di Chimica, Università degli Studi di Bari “Aldo Moro,” 70125 Bari, Italy. |

⁶

Intersail Engineering, Via Pianette, 25064 Gussago, Brescia, Italy. |

Publication type: Journal Article

Publication date: 2022-07-08

American Association for the Advancement of Science (AAAS)

Journal: Science advances

Quartile SCImago

Quartile WOS

Impact factor: 13.6

ISSN: 23752548

DOI: 10.1126/sciadv.abo0881

Copy DOI

Multidisciplinary

Abstract

Molecular tests are highly reliable and sensitive but lack portability and are not simple to use; conversely, easy-to-use antigenic tests still lack high performance. BioScreen combines single-molecule sensitivity and outstanding reliability with ultraportability and simplicity of use. This digital platform is capable of artificial intelligence–based binary classification at the limit of identification of a single marker/virus in 0.1 ml. The diagnostic sensitivity, specificity, and accuracy reach 99.2% as validated through 240 assays, including a pilot clinical trial. The versatile immunometric system can detect the SARS-CoV-2 virus, spike S1, and immunoglobulin G antigen proteins in saliva, blood serum, and swab. BioScreen has a small footprint comprising a disposable cartridge and a handheld electronic reader connected to a smart device. The sample handling is minimal, and the assay time to result is 21 min. Reliable and sensitive self-testing with an ultraportable and easy-to-use diagnostic system operated directly by a patient holds the potential to revolutionize point-of-care testing and early diagnosis.

By date By citations

Top-30

Citations by journals

	1 2 3 4
Advanced Materials	Advanced Materials, 4, 9.3% Advanced Materials 4 publications, 9.3%
Biosensors	Biosensors, 3, 6.98% Biosensors 3 publications, 6.98%
Biosensors and Bioelectronics	Biosensors and Bioelectronics, 3, 6.98% Biosensors and Bioelectronics 3 publications, 6.98%
Advanced Science	Advanced Science, 3, 6.98% Advanced Science 3 publications, 6.98%
ACS applied materials & interfaces	ACS applied materials & interfaces, 3, 6.98% ACS applied materials & interfaces 3 publications, 6.98%
Advanced Materials Interfaces	Advanced Materials Interfaces, 2, 4.65% Advanced Materials Interfaces 2 publications, 4.65%
Nature Communications	Nature Communications, 2, 4.65% Nature Communications 2 publications, 4.65%
Advanced Sensor Research	Advanced Sensor Research, 2, 4.65% Advanced Sensor Research 2 publications, 4.65%
Advanced Materials Technologies	Advanced Materials Technologies, 1, 2.33% Advanced Materials Technologies 1 publication, 2.33%
Nano Today	Nano Today, 1, 2.33% Nano Today 1 publication, 2.33%
PLOS Global Public Health	PLOS Global Public Health, 1, 2.33% PLOS Global Public Health 1 publication, 2.33%
Advanced Functional Materials	Advanced Functional Materials, 1, 2.33% Advanced Functional Materials 1 publication, 2.33%
Bioengineering & Translational Medicine	Bioengineering & Translational Medicine, 1, 2.33% Bioengineering & Translational Medicine 1 publication, 2.33%
Chemosensors	Chemosensors, 1, 2.33% Chemosensors 1 publication, 2.33%
Chemistry - A European Journal	Chemistry - A European Journal, 1, 2.33% Chemistry - A European Journal 1 publication, 2.33%
Science of the Total Environment	Science of the Total Environment, 1, 2.33% Science of the Total Environment 1 publication, 2.33%
Next Nanotechnology	Next Nanotechnology, 1, 2.33% Next Nanotechnology 1 publication, 2.33%
Bioelectronic Medicine	Bioelectronic Medicine, 1, 2.33% Bioelectronic Medicine 1 publication, 2.33%
Journal of Materials Chemistry C	Journal of Materials Chemistry C, 1, 2.33% Journal of Materials Chemistry C 1 publication, 2.33%
Interdisciplinary Medicine	Interdisciplinary Medicine, 1, 2.33% Interdisciplinary Medicine 1 publication, 2.33%
Russian Chemical Reviews	Russian Chemical Reviews, 1, 2.33% Russian Chemical Reviews 1 publication, 2.33%
Nature Reviews Bioengineering	Nature Reviews Bioengineering, 1, 2.33% Nature Reviews Bioengineering 1 publication, 2.33%
Small	Small, 1, 2.33% Small 1 publication, 2.33%
Annual Review of Analytical Chemistry	Annual Review of Analytical Chemistry, 1, 2.33% Annual Review of Analytical Chemistry 1 publication, 2.33%
	1 2 3 4

Citations by publishers

	2 4 6 8 10 12 14 16 18
Wiley	Wiley, 17, 39.53% Wiley 17 publications, 39.53%
Elsevier	Elsevier, 6, 13.95% Elsevier 6 publications, 13.95%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 4, 9.3% Multidisciplinary Digital Publishing Institute (MDPI) 4 publications, 9.3%
Springer Nature	Springer Nature, 4, 9.3% Springer Nature 4 publications, 9.3%
American Chemical Society (ACS)	American Chemical Society (ACS), 3, 6.98% American Chemical Society (ACS) 3 publications, 6.98%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 2, 4.65% Cold Spring Harbor Laboratory 2 publications, 4.65%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 2.33% Public Library of Science (PLoS) 1 publication, 2.33%
IEEE	IEEE, 1, 2.33% IEEE 1 publication, 2.33%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 2.33% Royal Society of Chemistry (RSC) 1 publication, 2.33%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 2.33% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 2.33%
Annual Reviews	Annual Reviews, 1, 2.33% Annual Reviews 1 publication, 2.33%
	2 4 6 8 10 12 14 16 18

We do not take into account publications without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2022,2023,2024],"ids":[0,0,0],"codes":[0,0,0],"imageUrls":["","",""],"datasets":[{"label":"Citations number","data":[7,21,15],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6"],"percentage":["16.28","48.84","34.88"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Advanced Materials","Biosensors","Biosensors and Bioelectronics","Advanced Science","ACS applied materials & interfaces","Advanced Materials Interfaces","Nature Communications","Advanced Sensor Research","Advanced Materials Technologies","Nano Today","PLOS Global Public Health","Advanced Functional Materials","Bioengineering & Translational Medicine","Chemosensors","Chemistry - A European Journal","Science of the Total Environment","Next Nanotechnology","Bioelectronic Medicine","Journal of Materials Chemistry C","Interdisciplinary Medicine","Russian Chemical Reviews","Nature Reviews Bioengineering","Small","Annual Review of Analytical Chemistry"],"ids":[25159,5233,18799,4130,1458,18764,3231,29363,114,1433,28949,7715,26725,2627,24708,2679,35618,27791,3848,29950,23802,30634,9872,2861],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/9Mus3KG1Tkd7Bwaurt8H3RwWh0CxRlGoO6ng9UK1_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/A7oGMwx1m3fFJlKJvQUVra8h0itmEa7JZW0q3Q0b_medium.webp"],"datasets":[{"label":"","data":[4,3,3,3,3,2,2,2,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[9.3,6.98,6.98,6.98,6.98,4.65,4.65,4.65,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Wiley","Elsevier","Multidisciplinary Digital Publishing Institute (MDPI)","Springer Nature","American Chemical Society (ACS)","Cold Spring Harbor Laboratory","Public Library of Science (PLoS)","IEEE","Royal Society of Chemistry (RSC)","Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii","Annual Reviews"],"ids":[11,17,202,8,40,6909,344,6953,123,9422,6941],"codes":[0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/hg4jJjT8wVGtHstBCc0zk465Mg9pLx3G4odCDOqE_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/6scCJegesojp2jubwY3uKCzTAmgsaH2GIFlg6Hfk_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/9Mus3KG1Tkd7Bwaurt8H3RwWh0CxRlGoO6ng9UK1_medium.webp","\/storage\/images\/resized\/A7oGMwx1m3fFJlKJvQUVra8h0itmEa7JZW0q3Q0b_medium.webp"],"datasets":[{"label":"","data":[17,6,4,4,3,2,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[39.53,13.95,9.3,9.3,6.98,4.65,2.33,2.33,2.33,2.33,2.33],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartiles":{"type":"bar","data":{"show":true,"labels":[2022,2023,2024],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,0,0],"percentage":["0","0","0"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[0,0,0],"percentage":["0","0","0"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[0,1,0],"percentage":["0","2.33","0"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[3,15,12],"percentage":["6.98","34.88","27.91"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[4,5,3],"percentage":["9.3","11.63","6.98"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by SCImago per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartilesWs":{"type":"bar","data":{"show":true,"labels":[2022,2023,2024],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,0,0],"percentage":["0","0","0"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[0,0,0],"percentage":["0","0","0"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[1,3,0],"percentage":["2.33","6.98","0"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[2,13,12],"percentage":["4.65","30.23","27.91"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[4,5,3],"percentage":["9.3","11.63","6.98"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by WoS per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Publication PDF

Metrics

Cite this

GOST |

Cite this

GOST Copy

Macchia E. et al. A handheld intelligent single-molecule binary bioelectronic system for fast and reliable immunometric point-of-care testing // Science advances. 2022. Vol. 8. No. 27.

GOST all authors (up to 50) Copy

Macchia E., Kovács Vajna Z. M., Loconsole D., Sarcina L., Redolfi M., Chironna M., Torricelli F., Torsi L. A handheld intelligent single-molecule binary bioelectronic system for fast and reliable immunometric point-of-care testing // Science advances. 2022. Vol. 8. No. 27.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1126/sciadv.abo0881

UR - https://doi.org/10.1126/sciadv.abo0881

TI - A handheld intelligent single-molecule binary bioelectronic system for fast and reliable immunometric point-of-care testing

T2 - Science advances

AU - Macchia, Eleonora

AU - Kovács Vajna, Zsolt M

AU - Loconsole, Daniela

AU - Sarcina, Lucia

AU - Redolfi, Massimiliano

AU - Chironna, Maria

AU - Torricelli, Fabrizio

AU - Torsi, L.

PY - 2022

DA - 2022/07/08 00:00:00

PB - American Association for the Advancement of Science (AAAS)

IS - 27

VL - 8

SN - 2375-2548

ER -

BibTex

Cite this

BibTex Copy

@article{2022_Macchia,

author = {Eleonora Macchia and Zsolt M Kovács Vajna and Daniela Loconsole and Lucia Sarcina and Massimiliano Redolfi and Maria Chironna and Fabrizio Torricelli and L. Torsi},

title = {A handheld intelligent single-molecule binary bioelectronic system for fast and reliable immunometric point-of-care testing},

journal = {Science advances},

year = {2022},

volume = {8},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {jul},

url = {https://doi.org/10.1126/sciadv.abo0881},

number = {27},

doi = {10.1126/sciadv.abo0881}

}

Found error?

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science advances

Quartile SCImago

Quartile WOS

Impact factor

13.6

ISSN

23752548 (Electronic)