Open Access

Science, volume 317, issue 5839, pages 783-787

Label-Free, Single-Molecule Detection with Optical Microcavities

Andrea M Armani ^{1, 2, 3}

Rajan P Kulkarni ^{1, 2, 3}

Scott E. Fraser ^{1, 2, 3}

Richard C. Flagan ^{1, 2, 3}

KERRY J. VAHALA ^{1, 2, 3}

Hide authors affiliations Show authors affiliations: 3 affiliations

Department of Applied Physics, MC 128-95, California Institute of Technology, Pasadena, CA 91125, USA. |

Division of Biology, MC 139-74, California Institute of Technology, Pasadena, CA 91125, USA. |

Division of Chemistry and Chemical Engineering, MC 210-41, California Institute of Technology, Pasadena, CA 91125, USA. |

Publication type: Journal Article

Publication date: 2007-08-10

American Association for the Advancement of Science (AAAS)

Journal: Science

Quartile SCImago

Quartile WOS

Impact factor: 56.9

ISSN: 00368075, 10959203

DOI: 10.1126/science.1145002

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Multidisciplinary

Abstract

Current single-molecule detection techniques require labeling the target molecule. We report a highly specific and sensitive optical sensor based on an ultrahigh quality (Q) factor (Q > 108) whispering-gallery microcavity. The silica surface is functionalized to bind the target molecule; binding is detected by a resonant wavelength shift. Single-molecule detection is confirmed by observation of single-molecule binding events that shift the resonant frequency, as well as by the statistics for these shifts over many binding events. These shifts result from a thermo-optic mechanism. Additionally, label-free, single-molecule detection of interleukin-2 was demonstrated in serum. These experiments demonstrate a dynamic range of 1012 in concentration, establishing the microcavity as a sensitive and versatile detector.

By date By citations

Top-30

Citations by journals

	10 20 30 40 50 60 70 80 90
Optics Express	Optics Express, 85, 8.99% Optics Express 85 publications, 8.99%
Applied Physics Letters	Applied Physics Letters, 50, 5.29% Applied Physics Letters 50 publications, 5.29%
Optics Letters	Optics Letters, 31, 3.28% Optics Letters 31 publications, 3.28%
Sensors	Sensors, 26, 2.75% Sensors 26 publications, 2.75%
Physical Review A	Physical Review A, 23, 2.43% Physical Review A 23 publications, 2.43%
Analytical Chemistry	Analytical Chemistry, 23, 2.43% Analytical Chemistry 23 publications, 2.43%
Proceedings of SPIE - The International Society for Optical Engineering	Proceedings of SPIE - The International Society for Optical Engineering, 22, 2.33% Proceedings of SPIE - The International Society for Optical Engineering 22 publications, 2.33%
Journal of the Optical Society of America B: Optical Physics	Journal of the Optical Society of America B: Optical Physics, 18, 1.9% Journal of the Optical Society of America B: Optical Physics 18 publications, 1.9%
Optics Communications	Optics Communications, 16, 1.69% Optics Communications 16 publications, 1.69%
Nano Letters	Nano Letters, 16, 1.69% Nano Letters 16 publications, 1.69%
IEEE Photonics Technology Letters	IEEE Photonics Technology Letters, 15, 1.59% IEEE Photonics Technology Letters 15 publications, 1.59%
Scientific Reports	Scientific Reports, 14, 1.48% Scientific Reports 14 publications, 1.48%
Sensors and Actuators, B: Chemical	Sensors and Actuators, B: Chemical, 13, 1.37% Sensors and Actuators, B: Chemical 13 publications, 1.37%
Advanced Optical Materials	Advanced Optical Materials, 13, 1.37% Advanced Optical Materials 13 publications, 1.37%
Lab on a Chip	Lab on a Chip, 12, 1.27% Lab on a Chip 12 publications, 1.27%
IEEE Sensors Journal	IEEE Sensors Journal, 10, 1.06% IEEE Sensors Journal 10 publications, 1.06%
Nature Photonics	Nature Photonics, 9, 0.95% Nature Photonics 9 publications, 0.95%
Nature Communications	Nature Communications, 9, 0.95% Nature Communications 9 publications, 0.95%
Optik	Optik, 9, 0.95% Optik 9 publications, 0.95%
Journal of Lightwave Technology	Journal of Lightwave Technology, 9, 0.95% Journal of Lightwave Technology 9 publications, 0.95%
Analytical and Bioanalytical Chemistry	Analytical and Bioanalytical Chemistry, 8, 0.85% Analytical and Bioanalytical Chemistry 8 publications, 0.85%
IEEE Journal of Selected Topics in Quantum Electronics	IEEE Journal of Selected Topics in Quantum Electronics, 8, 0.85% IEEE Journal of Selected Topics in Quantum Electronics 8 publications, 0.85%
Physical Review Letters	Physical Review Letters, 7, 0.74% Physical Review Letters 7 publications, 0.74%
Biosensors and Bioelectronics	Biosensors and Bioelectronics, 7, 0.74% Biosensors and Bioelectronics 7 publications, 0.74%
ACS Nano	ACS Nano, 7, 0.74% ACS Nano 7 publications, 0.74%
ACS Photonics	ACS Photonics, 7, 0.74% ACS Photonics 7 publications, 0.74%
Nanoscale	Nanoscale, 7, 0.74% Nanoscale 7 publications, 0.74%
The Analyst	The Analyst, 7, 0.74% The Analyst 7 publications, 0.74%
IEEE Photonics Journal	IEEE Photonics Journal, 7, 0.74% IEEE Photonics Journal 7 publications, 0.74%
	10 20 30 40 50 60 70 80 90

Citations by publishers

	20 40 60 80 100 120 140 160
Optical Society of America	Optical Society of America, 158, 16.7% Optical Society of America 158 publications, 16.7%
Elsevier	Elsevier, 101, 10.68% Elsevier 101 publications, 10.68%
Springer Nature	Springer Nature, 91, 9.62% Springer Nature 91 publications, 9.62%
American Chemical Society (ACS)	American Chemical Society (ACS), 75, 7.93% American Chemical Society (ACS) 75 publications, 7.93%
IEEE	IEEE, 70, 7.4% IEEE 70 publications, 7.4%
American Institute of Physics (AIP)	American Institute of Physics (AIP), 61, 6.45% American Institute of Physics (AIP) 61 publications, 6.45%
Wiley	Wiley, 59, 6.24% Wiley 59 publications, 6.24%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 49, 5.18% Multidisciplinary Digital Publishing Institute (MDPI) 49 publications, 5.18%
American Physical Society (APS)	American Physical Society (APS), 42, 4.44% American Physical Society (APS) 42 publications, 4.44%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 41, 4.33% Royal Society of Chemistry (RSC) 41 publications, 4.33%
SPIE	SPIE, 30, 3.17% SPIE 30 publications, 3.17%
IOP Publishing	IOP Publishing, 22, 2.33% IOP Publishing 22 publications, 2.33%
Taylor & Francis	Taylor & Francis, 7, 0.74% Taylor & Francis 7 publications, 0.74%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 6, 0.63% American Association for the Advancement of Science (AAAS) 6 publications, 0.63%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 6, 0.63% Proceedings of the National Academy of Sciences (PNAS) 6 publications, 0.63%
Walter de Gruyter	Walter de Gruyter, 5, 0.53% Walter de Gruyter 5 publications, 0.53%
Trans Tech Publications	Trans Tech Publications, 5, 0.53% Trans Tech Publications 5 publications, 0.53%
Japan Society of Applied Physics	Japan Society of Applied Physics, 4, 0.42% Japan Society of Applied Physics 4 publications, 0.42%
Pleiades Publishing	Pleiades Publishing, 4, 0.42% Pleiades Publishing 4 publications, 0.42%
American Vacuum Society	American Vacuum Society, 2, 0.21% American Vacuum Society 2 publications, 0.21%
Maruzen Co., Ltd/Maruzen Kabushikikaisha	Maruzen Co., Ltd/Maruzen Kabushikikaisha, 2, 0.21% Maruzen Co., Ltd/Maruzen Kabushikikaisha 2 publications, 0.21%
V. N. Orekhovich Research Institute of Biomedical Chemistry	V. N. Orekhovich Research Institute of Biomedical Chemistry, 2, 0.21% V. N. Orekhovich Research Institute of Biomedical Chemistry 2 publications, 0.21%
Chinese Physical Society	Chinese Physical Society, 2, 0.21% Chinese Physical Society 2 publications, 0.21%
Hindawi Limited	Hindawi Limited, 2, 0.21% Hindawi Limited 2 publications, 0.21%
Begell House	Begell House, 1, 0.11% Begell House 1 publication, 0.11%
Canadian Science Publishing	Canadian Science Publishing, 1, 0.11% Canadian Science Publishing 1 publication, 0.11%
EDP Sciences	EDP Sciences, 1, 0.11% EDP Sciences 1 publication, 0.11%
Institution of Engineering and Technology (IET)	Institution of Engineering and Technology (IET), 1, 0.11% Institution of Engineering and Technology (IET) 1 publication, 0.11%
IOS Press	IOS Press, 1, 0.11% IOS Press 1 publication, 0.11%
	20 40 60 80 100 120 140 160

We do not take into account publications without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

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Armani A. M. et al. Label-Free, Single-Molecule Detection with Optical Microcavities // Science. 2007. Vol. 317. No. 5839. pp. 783-787.

GOST all authors (up to 50) Copy

Armani A. M., Kulkarni R. P., Fraser S. E., Flagan R. C., VAHALA K. J. Label-Free, Single-Molecule Detection with Optical Microcavities // Science. 2007. Vol. 317. No. 5839. pp. 783-787.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1126/science.1145002

UR - https://doi.org/10.1126/science.1145002

TI - Label-Free, Single-Molecule Detection with Optical Microcavities

T2 - Science

AU - Armani, Andrea M

AU - Kulkarni, Rajan P

AU - Fraser, Scott E.

AU - Flagan, Richard C.

AU - VAHALA, KERRY J.

PY - 2007

DA - 2007/08/10 00:00:00

PB - American Association for the Advancement of Science (AAAS)

SP - 783-787

IS - 5839

VL - 317

SN - 0036-8075

SN - 1095-9203

ER -

BibTex |

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BibTex Copy

@article{2007_Armani,

author = {Andrea M Armani and Rajan P Kulkarni and Scott E. Fraser and Richard C. Flagan and KERRY J. VAHALA},

title = {Label-Free, Single-Molecule Detection with Optical Microcavities},

journal = {Science},

year = {2007},

volume = {317},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {aug},

url = {https://doi.org/10.1126/science.1145002},

number = {5839},

pages = {783--787},

doi = {10.1126/science.1145002}

}

MLA

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MLA Copy

Armani, Andrea M., et al. “Label-Free, Single-Molecule Detection with Optical Microcavities.” Science, vol. 317, no. 5839, Aug. 2007, pp. 783-787. https://doi.org/10.1126/science.1145002.

Found error?

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science

Quartile SCImago

Quartile WOS

Impact factor

56.9

ISSN

00368075 (Print)
10959203 (Electronic)