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том 343 издание 6177 страницы 1363-1366

Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand

Тип публикацииJournal Article
Дата публикации2014-03-21
scimago Q1
wos Q1
БС1
SJR10.416
CiteScore48.4
Impact factor45.8
ISSN00368075, 10959203
Multidisciplinary
Краткое описание
Translocation in Injury

The translocator protein TSPO is essential for the import of cholesterol and porphyrins into mitochondria. TSPO expression increases in areas of brain injury and during neuroinflammation and, thus, has diagnostic and therapeutic implications. Jaremko et al. (p. 1363 ) used nuclear magnetic resonance spectroscopy to determine the high-resolution structure of the 18- kilodalton mammalian TSPO with the ligand PK11195, which stabilized the structure and resolved the conformation as a tight bundle of five helices.

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ГОСТ |
Цитировать
Jaremko Ł. et al. Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand // Science. 2014. Vol. 343. No. 6177. pp. 1363-1366.
ГОСТ со всеми авторами (до 50) Скопировать
Jaremko Ł., Jaremko M., Giller K., Becker S., Zweckstetter M. Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand // Science. 2014. Vol. 343. No. 6177. pp. 1363-1366.
RIS |
Цитировать
TY - JOUR
DO - 10.1126/science.1248725
UR - https://doi.org/10.1126/science.1248725
TI - Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand
T2 - Science
AU - Jaremko, Łukasz
AU - Jaremko, Mariusz
AU - Giller, Karin
AU - Becker, Stefan
AU - Zweckstetter, Markus
PY - 2014
DA - 2014/03/21
PB - American Association for the Advancement of Science (AAAS)
SP - 1363-1366
IS - 6177
VL - 343
PMID - 24653034
SN - 0036-8075
SN - 1095-9203
ER -
BibTex |
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BibTex (до 50 авторов) Скопировать
@article{2014_Jaremko,
author = {Łukasz Jaremko and Mariusz Jaremko and Karin Giller and Stefan Becker and Markus Zweckstetter},
title = {Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand},
journal = {Science},
year = {2014},
volume = {343},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {mar},
url = {https://doi.org/10.1126/science.1248725},
number = {6177},
pages = {1363--1366},
doi = {10.1126/science.1248725}
}
MLA
Цитировать
Jaremko, Łukasz, et al. “Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand.” Science, vol. 343, no. 6177, Mar. 2014, pp. 1363-1366. https://doi.org/10.1126/science.1248725.