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Open access
volume 343 issue 6177 pages 1363-1366

Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand

Publication typeJournal Article
Publication date2014-03-21
scimago Q1
wos Q1
SJR10.416
CiteScore48.4
Impact factor45.8
ISSN00368075, 10959203
Multidisciplinary
Abstract
Translocation in Injury

The translocator protein TSPO is essential for the import of cholesterol and porphyrins into mitochondria. TSPO expression increases in areas of brain injury and during neuroinflammation and, thus, has diagnostic and therapeutic implications. Jaremko et al. (p. 1363 ) used nuclear magnetic resonance spectroscopy to determine the high-resolution structure of the 18- kilodalton mammalian TSPO with the ligand PK11195, which stabilized the structure and resolved the conformation as a tight bundle of five helices.

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GOST |
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GOST Copy
Jaremko Ł. et al. Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand // Science. 2014. Vol. 343. No. 6177. pp. 1363-1366.
GOST all authors (up to 50) Copy
Jaremko Ł., Jaremko M., Giller K., Becker S., Zweckstetter M. Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand // Science. 2014. Vol. 343. No. 6177. pp. 1363-1366.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1126/science.1248725
UR - https://doi.org/10.1126/science.1248725
TI - Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand
T2 - Science
AU - Jaremko, Łukasz
AU - Jaremko, Mariusz
AU - Giller, Karin
AU - Becker, Stefan
AU - Zweckstetter, Markus
PY - 2014
DA - 2014/03/21
PB - American Association for the Advancement of Science (AAAS)
SP - 1363-1366
IS - 6177
VL - 343
PMID - 24653034
SN - 0036-8075
SN - 1095-9203
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2014_Jaremko,
author = {Łukasz Jaremko and Mariusz Jaremko and Karin Giller and Stefan Becker and Markus Zweckstetter},
title = {Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand},
journal = {Science},
year = {2014},
volume = {343},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {mar},
url = {https://doi.org/10.1126/science.1248725},
number = {6177},
pages = {1363--1366},
doi = {10.1126/science.1248725}
}
MLA
Cite this
MLA Copy
Jaremko, Łukasz, et al. “Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand.” Science, vol. 343, no. 6177, Mar. 2014, pp. 1363-1366. https://doi.org/10.1126/science.1248725.