Open Access
The Receptor for the Cytotoxic Ligand TRAIL
Guohua Pan
1
,
Karen O'Rourke
1
,
Arul M. Chinnaiyan
1
,
REINER GENTZ
2
,
Reinhard Ebner
2
,
Jian Ni
2
,
Vishva M. Dixit
1
2
Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850-3338, USA.
|
Publication type: Journal Article
Publication date: 1997-04-04
scimago Q1
wos Q1
SJR: 10.416
CiteScore: 48.4
Impact factor: 45.8
ISSN: 00368075, 10959203
PubMed ID:
9082980
Multidisciplinary
Abstract
TRAIL (also known as Apo-2L) is a member of the tumor necrosis factor (TNF) ligand family that rapidly induces apoptosis in a variety of transformed cell lines. The human receptor for TRAIL was found to be an undescribed member of the TNF-receptor family (designated death receptor-4, DR4) that contains a cytoplasmic “death domain” capable of engaging the cell suicide apparatus but not the nuclear factor kappa B pathway in the system studied. Unlike Fas, TNFR-1, and DR3, DR4 could not use FADD to transmit the death signal, suggesting the use of distinct proximal signaling machinery. Thus, the DR4-TRAIL axis defines another receptor-ligand pair involved in regulating cell suicide and tissue homeostasis.
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1.4k
Total citations:
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Citations from 2024:
35
(2.48%)
Cite this
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MLA
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GOST
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Pan G. et al. The Receptor for the Cytotoxic Ligand TRAIL // Science. 1997. Vol. 276. No. 5309. pp. 111-113.
GOST all authors (up to 50)
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Pan G., O'Rourke K., Chinnaiyan A. M., GENTZ R., Ebner R., Ni J., Dixit V. M. The Receptor for the Cytotoxic Ligand TRAIL // Science. 1997. Vol. 276. No. 5309. pp. 111-113.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1126/science.276.5309.111
UR - https://doi.org/10.1126/science.276.5309.111
TI - The Receptor for the Cytotoxic Ligand TRAIL
T2 - Science
AU - Pan, Guohua
AU - O'Rourke, Karen
AU - Chinnaiyan, Arul M.
AU - GENTZ, REINER
AU - Ebner, Reinhard
AU - Ni, Jian
AU - Dixit, Vishva M.
PY - 1997
DA - 1997/04/04
PB - American Association for the Advancement of Science (AAAS)
SP - 111-113
IS - 5309
VL - 276
PMID - 9082980
SN - 0036-8075
SN - 1095-9203
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1997_Pan,
author = {Guohua Pan and Karen O'Rourke and Arul M. Chinnaiyan and REINER GENTZ and Reinhard Ebner and Jian Ni and Vishva M. Dixit},
title = {The Receptor for the Cytotoxic Ligand TRAIL},
journal = {Science},
year = {1997},
volume = {276},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {apr},
url = {https://doi.org/10.1126/science.276.5309.111},
number = {5309},
pages = {111--113},
doi = {10.1126/science.276.5309.111}
}
Cite this
MLA
Copy
Pan, Guohua, et al. “The Receptor for the Cytotoxic Ligand TRAIL.” Science, vol. 276, no. 5309, Apr. 1997, pp. 111-113. https://doi.org/10.1126/science.276.5309.111.