Open Access
A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen
Antonietta Impagliazzo
1
,
Fin Milder
1
,
Harmjan Kuipers
1
,
Michelle V Wagner
2
,
Xueyong Zhu
3
,
Ryan M B Hoffman
3
,
Ruud Van Meersbergen
1
,
Jeroen Huizingh
1
,
Patrick Wanningen
1
,
Johan Verspuij
1
,
Martijn De Man
1
,
Zhaoqing Ding
2
,
Adrian Apetri
1
,
Basak Kukrer
1
,
Eveline Sneekes Vriese
1
,
Danuta Tomkiewicz
1
,
Nick S Laursen
3
,
Peter S. Lee
3
,
Anna Zakrzewska
1
,
Liesbeth Dekking
1
,
Jeroen Tolboom
1
,
Lisanne Tettero
1
,
Sander Van Meerten
1
,
Wenli Yu
3
,
Wouter Koudstaal
1
,
Jaap Goudsmit
1
,
Andrew B. Ward
3
,
Wim Meijberg
1
,
IAN A. WILSON
3
,
Katarina Radošević
1
1
Crucell Vaccine Institute, Janssen Center of Excellence for Immunoprophylaxis, Archimedesweg 4-6, 2301 CA Leiden, Netherlands.
|
2
Crucell Vaccine Institute, Janssen Center of Excellence for Immunoprophylaxis, 3210 Merryfield Row, San Diego, CA 92121, USA.
|
Publication type: Journal Article
Publication date: 2015-09-18
scimago Q1
wos Q1
SJR: 10.416
CiteScore: 48.4
Impact factor: 45.8
ISSN: 00368075, 10959203
PubMed ID:
26303961
Multidisciplinary
Abstract
Flu vaccine candidate STEMs the tide
Every year we need a new flu vaccine, because influenza virus constantly mutates the major target of antibodies to flu: the “head” region of the viral hemagglutinin (HA) protein. Avoiding the problem of mutation requires a vaccine that elicits antibodies against the more conserved “stem” region of HA. During infection, antibodies are occasionally produced that recognize the stem and that neutralize a broad range of influenza virus strains. Impagliazzo et al. engineered an HA stem–only vaccine candidate that elicited broadly neutralizing antibodies in mice and nonhuman primates and that protected mice against multiple influenza strains.
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Total citations:
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Citations from 2025:
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Impagliazzo A. et al. A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen // Science. 2015. Vol. 349. No. 6254. pp. 1301-1306.
GOST all authors (up to 50)
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Impagliazzo A., Milder F., Kuipers H., Wagner M. V., Zhu X., Hoffman R. M. B., Van Meersbergen R., Huizingh J., Wanningen P., Verspuij J., De Man M., Ding Z., Apetri A., Kukrer B., Sneekes Vriese E., Tomkiewicz D., Laursen N. S., Lee P. S., Zakrzewska A., Dekking L., Tolboom J., Tettero L., Van Meerten S., Yu W., Koudstaal W., Goudsmit J., Ward A. B., Meijberg W., WILSON I. A., Radošević K. A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen // Science. 2015. Vol. 349. No. 6254. pp. 1301-1306.
Cite this
RIS
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TY - JOUR
DO - 10.1126/science.aac7263
UR - https://doi.org/10.1126/science.aac7263
TI - A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen
T2 - Science
AU - Impagliazzo, Antonietta
AU - Milder, Fin
AU - Kuipers, Harmjan
AU - Wagner, Michelle V
AU - Zhu, Xueyong
AU - Hoffman, Ryan M B
AU - Van Meersbergen, Ruud
AU - Huizingh, Jeroen
AU - Wanningen, Patrick
AU - Verspuij, Johan
AU - De Man, Martijn
AU - Ding, Zhaoqing
AU - Apetri, Adrian
AU - Kukrer, Basak
AU - Sneekes Vriese, Eveline
AU - Tomkiewicz, Danuta
AU - Laursen, Nick S
AU - Lee, Peter S.
AU - Zakrzewska, Anna
AU - Dekking, Liesbeth
AU - Tolboom, Jeroen
AU - Tettero, Lisanne
AU - Van Meerten, Sander
AU - Yu, Wenli
AU - Koudstaal, Wouter
AU - Goudsmit, Jaap
AU - Ward, Andrew B.
AU - Meijberg, Wim
AU - WILSON, IAN A.
AU - Radošević, Katarina
PY - 2015
DA - 2015/09/18
PB - American Association for the Advancement of Science (AAAS)
SP - 1301-1306
IS - 6254
VL - 349
PMID - 26303961
SN - 0036-8075
SN - 1095-9203
ER -
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BibTex (up to 50 authors)
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@article{2015_Impagliazzo,
author = {Antonietta Impagliazzo and Fin Milder and Harmjan Kuipers and Michelle V Wagner and Xueyong Zhu and Ryan M B Hoffman and Ruud Van Meersbergen and Jeroen Huizingh and Patrick Wanningen and Johan Verspuij and Martijn De Man and Zhaoqing Ding and Adrian Apetri and Basak Kukrer and Eveline Sneekes Vriese and Danuta Tomkiewicz and Nick S Laursen and Peter S. Lee and Anna Zakrzewska and Liesbeth Dekking and Jeroen Tolboom and Lisanne Tettero and Sander Van Meerten and Wenli Yu and Wouter Koudstaal and Jaap Goudsmit and Andrew B. Ward and Wim Meijberg and IAN A. WILSON and Katarina Radošević},
title = {A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen},
journal = {Science},
year = {2015},
volume = {349},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {sep},
url = {https://doi.org/10.1126/science.aac7263},
number = {6254},
pages = {1301--1306},
doi = {10.1126/science.aac7263}
}
Cite this
MLA
Copy
Impagliazzo, Antonietta, et al. “A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen.” Science, vol. 349, no. 6254, Sep. 2015, pp. 1301-1306. https://doi.org/10.1126/science.aac7263.