Open Access
Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM
Publication type: Journal Article
Publication date: 2019-04-26
scimago Q1
wos Q1
SJR: 10.416
CiteScore: 48.4
Impact factor: 45.8
ISSN: 00368075, 10959203
PubMed ID:
30975770
Multidisciplinary
Abstract
Diversity in ion channel complexes
AMPA receptors are glutamate activated ion channels that mediate fast synaptic transmission in the nervous system and play a key role in learning and memory. The receptors are tetramers built from various combinations of four subunits, with functional diversity coming from the range of subunit compositions. Zhao et al. purified native receptors from rat brains and determined the structures of 10 different complexes by cryo–electron microscopy. Certain arrangements of the four subunits are preferred. The structure of a key gating element—a linker between the transmembrane and ligand binding domains—reveals how this receptor may function.
Science
, this issue p.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
2
4
6
8
10
|
|
|
Nature Communications
10 publications, 5.62%
|
|
|
Neuropharmacology
9 publications, 5.06%
|
|
|
Nature
8 publications, 4.49%
|
|
|
eLife
8 publications, 4.49%
|
|
|
bioRxiv
7 publications, 3.93%
|
|
|
International Journal of Molecular Sciences
4 publications, 2.25%
|
|
|
Molecular Neurobiology
4 publications, 2.25%
|
|
|
Nature Structural and Molecular Biology
4 publications, 2.25%
|
|
|
Cell Reports
4 publications, 2.25%
|
|
|
Journal of Biological Chemistry
4 publications, 2.25%
|
|
|
Journal of Physiology
4 publications, 2.25%
|
|
|
Proceedings of the National Academy of Sciences of the United States of America
4 publications, 2.25%
|
|
|
Scientific Reports
3 publications, 1.69%
|
|
|
Frontiers in Molecular Neuroscience
2 publications, 1.12%
|
|
|
Cells
2 publications, 1.12%
|
|
|
Biomolecules
2 publications, 1.12%
|
|
|
PLoS ONE
2 publications, 1.12%
|
|
|
Cellular and Molecular Life Sciences
2 publications, 1.12%
|
|
|
Bioorganic Chemistry
2 publications, 1.12%
|
|
|
Journal of Molecular Biology
2 publications, 1.12%
|
|
|
Neuron
2 publications, 1.12%
|
|
|
Current Opinion in Neurobiology
2 publications, 1.12%
|
|
|
Biochimica et Biophysica Acta - Biomembranes
2 publications, 1.12%
|
|
|
Journal of Neuroscience
2 publications, 1.12%
|
|
|
Science
2 publications, 1.12%
|
|
|
Journal of General Physiology
2 publications, 1.12%
|
|
|
Pharmacological Reviews
1 publication, 0.56%
|
|
|
Molecular Pharmacology
1 publication, 0.56%
|
|
|
Biochemical Society Transactions
1 publication, 0.56%
|
|
|
2
4
6
8
10
|
Publishers
|
5
10
15
20
25
30
35
40
45
|
|
|
Elsevier
41 publications, 23.03%
|
|
|
Springer Nature
40 publications, 22.47%
|
|
|
Cold Spring Harbor Laboratory
29 publications, 16.29%
|
|
|
Wiley
13 publications, 7.3%
|
|
|
MDPI
10 publications, 5.62%
|
|
|
eLife Sciences Publications
8 publications, 4.49%
|
|
|
Frontiers Media S.A.
4 publications, 2.25%
|
|
|
Proceedings of the National Academy of Sciences (PNAS)
4 publications, 2.25%
|
|
|
American Association for the Advancement of Science (AAAS)
3 publications, 1.69%
|
|
|
Rockefeller University Press
3 publications, 1.69%
|
|
|
American Society for Pharmacology and Experimental Therapeutics
2 publications, 1.12%
|
|
|
SAGE
2 publications, 1.12%
|
|
|
Public Library of Science (PLoS)
2 publications, 1.12%
|
|
|
American Society for Biochemistry and Molecular Biology
2 publications, 1.12%
|
|
|
American Chemical Society (ACS)
2 publications, 1.12%
|
|
|
Society for Neuroscience
2 publications, 1.12%
|
|
|
Portland Press
1 publication, 0.56%
|
|
|
Pleiades Publishing
1 publication, 0.56%
|
|
|
Taylor & Francis
1 publication, 0.56%
|
|
|
AME Publishing Company
1 publication, 0.56%
|
|
|
Institute of Electrical and Electronics Engineers (IEEE)
1 publication, 0.56%
|
|
|
Bentham Science Publishers Ltd.
1 publication, 0.56%
|
|
|
Oxford University Press
1 publication, 0.56%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 publication, 0.56%
|
|
|
Society of Nuclear Medicine
1 publication, 0.56%
|
|
|
5
10
15
20
25
30
35
40
45
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
178
Total citations:
178
Citations from 2025:
25
(14.04%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Zhao Y. et al. Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM // Science. 2019. Vol. 364. No. 6438. pp. 355-362.
GOST all authors (up to 50)
Copy
Zhao Y., Chen S., Swensen A. C., Qian W., Gouaux E. Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM // Science. 2019. Vol. 364. No. 6438. pp. 355-362.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1126/science.aaw8250
UR - https://doi.org/10.1126/science.aaw8250
TI - Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM
T2 - Science
AU - Zhao, Yan
AU - Chen, Shanshuang
AU - Swensen, Adam C
AU - Qian, Wei-Jun
AU - Gouaux, Eric
PY - 2019
DA - 2019/04/26
PB - American Association for the Advancement of Science (AAAS)
SP - 355-362
IS - 6438
VL - 364
PMID - 30975770
SN - 0036-8075
SN - 1095-9203
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Zhao,
author = {Yan Zhao and Shanshuang Chen and Adam C Swensen and Wei-Jun Qian and Eric Gouaux},
title = {Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM},
journal = {Science},
year = {2019},
volume = {364},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {apr},
url = {https://doi.org/10.1126/science.aaw8250},
number = {6438},
pages = {355--362},
doi = {10.1126/science.aaw8250}
}
Cite this
MLA
Copy
Zhao, Yan, et al. “Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM.” Science, vol. 364, no. 6438, Apr. 2019, pp. 355-362. https://doi.org/10.1126/science.aaw8250.