Open Access

Science

, volume 370 , issue 6521

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

Iouli E Gordon ^{1, 2, 3, 4}

Joseph Hiatt ^{1, 4, 5, 6, 7}

Mehdi Bouhaddou ^{1, 2, 3, 4}

Veronica V Rezelj ⁸

Svenja Ulferts ⁹

Hannes Braberg ^{1, 2, 3, 4}

Alexander S Jureka ¹⁰

Kirsten Obernier ^{1, 2, 3, 4}

Jeffrey Z Guo ^{1, 2, 3, 4}

Jyoti Batra ^{1, 2, 3, 4}

Robyn M Kaake ^{1, 2, 3, 4}

Andrew Weckstein ¹¹

Tristan W Owens ¹²

Meghna Gupta ¹²

Sergei Pourmal ¹²

Erron W. Titus ¹²

Merve Cakir ^{1, 2, 3, 4}

Margaret Soucheray ^{1, 2, 3, 4}

Michael Michael N. McGregor ^{1, 2, 3, 4}

Zeynep Cakir ^{1, 2, 3, 4}

Gwendolyn M. Jang ^{1, 2, 3, 4}

Matthew J Omeara ¹³

Tia A Tummino ^{1, 2, 14}

Ziyang Zhang ^{1, 2, 3, 15}

Hélène Foussard ^{1, 2, 3, 4}

Ajda Rojc ^{1, 2, 3, 4}

Yuan Zhou ^{1, 2, 3, 4}

Dmitry Kuchenov ^{1, 2, 3, 4}

Ruth Hüttenhain ^{1, 2, 3, 4}

Jiewei Xu ^{1, 2, 3, 4}

Manon Eckhardt ^{1, 2, 3, 4}

Danielle Swaney ^{1, 2, 3, 4}

Jacqueline M Fabius ^{1, 2}

Manisha Ummadi ^{1, 2, 3, 4}

Beril Tutuncuoglu ^{1, 2, 3, 4}

Ujjwal Rathore ^{1, 2, 3, 4}

Maya Modak ^{1, 2, 3, 4}

P Haas ^{1, 2, 3, 4}

Kelsey M Haas ^{1, 2, 3, 4}

Zun Zar Chi Naing ^{1, 2, 3, 4}

Ernst H. Pulido ^{1, 2, 3, 4}

Ying Shi ^{1, 2, 3, 15}

Inigo Barrio-Hernandez ¹⁶

Danish Memon ¹⁶

Eirini Petsalaki ¹⁶

Alistair S. Dunham ¹⁶

Miguel Correa Marrero ¹⁶

David F. Burke ¹⁶

Cassandra Koh ⁸

Thomas Vallet ⁸

Jesus A Silvas ¹⁰

C. M. Azumaya ¹²

Christian B Billesbølle ¹²

Axel F. Brilot ¹²

Melody Campbell ^{12, 17}

Amy Diallo ¹²

Miles Sasha Dickinson ¹²

Devan Diwanji ¹²

Nick Hoppe ¹²

H. Kratochvil ¹²

Yanxin Liu ¹²

Gregory E Merz ¹²

Michelle Moritz ¹²

Kim Cuong Nguyen ¹²

Carlos Nowotny ¹²

Cristina Puchades ¹²

Alexandrea Rizo ¹²

Ursula Schulze-Gahmen ¹²

Joel M Smith ¹²

Ming Sun ^{12, 18}

Iris D. Young ¹²

Jianhua Zhao ¹²

J. T. Biel ¹²

Alisa Bowen ¹²

Julian R Braxton ¹²

Cynthia M Chio ¹²

Un Seng Chio ¹²

Ishan Deshpande ¹²

Bryan Faust ¹²

Sebastian Flores ¹²

M Jin ¹²

K H Kim ¹²

Fei Li ¹²

Junrui Li ¹²

George C. Lu ¹²

Yang Li ¹²

Xi Liu ¹²

Megan Lo ¹²

Arthur A Melo ¹²

Frank R Moss ¹²

Joana Paulino ¹²

Komal Ishwar Pawar ¹²

Jessica K Peters ¹²

Thomas H Pospiech ¹²

Maliheh Safari ¹²

Smriti Sangwan ¹²

Paul V Thomas ¹²

Aye C Thwin ¹²

R Trenker ¹²

Eric Tse ¹²

Tsz Kin Martin Tsui ¹²

Feng Wang ¹²

Natalie Whitis ¹²

Yi-Fan Cheng ¹²

Kaihua Zhang ¹²

Sunny Zhang ¹²

D. Saltzberg ^{1, 2, 19}

Anthony J Hodder ²⁰

Amber S. Shun-Shion ²⁰

Daniel M. Williams ²⁰

Kris M White ^{21, 22}

Romel Rosales ^{21, 22}

Thomas Kehrer ^{21, 22}

Lisa Miorin ^{21, 22}

E. Moreno ^{21, 22}

Arvind Patel ²³

Suzannah Rihn ²³

Mir M. Khalid ⁴

Albert Vallejo Gracia ⁴

Parinaz Fozouni ^{4, 5, 7}

Camille R. Simoneau ^{4, 7}

Theodore L Roth ^{5, 6, 7}

David Wu ^{5, 7}

Mohd Anisul Karim ^{24, 25}

Maya Ghoussaini ^{24, 25}

Ian Dunham ^{16, 25}

Francesco Berardi ²⁶

Sebastian Weigang ²⁷

Maxime Chazal ²⁸

Jisoo Park ²⁹

James Logue ³⁰

Marisa McGrath ³⁰

Stuart Weston ³⁰

Robert Haupt ³⁰

C. James Hastie ³¹

M S Elliott ³¹

Fiona Brown ³¹

Kerry A Burness ³¹

Elaine Reid ³¹

Mark Dorward ³¹

Clare Johnson ³¹

Stuart G Wilkinson ³¹

Anna Geyer ³¹

Daniel M Giesel ³¹

Carla Baillie ³¹

Samantha Raggett ³¹

Hannah Leech ³¹

Rachel Toth ³¹

Nicola Goodman ³¹

Kathleen C Keough ⁴

Abigail L Lind ⁴

Reyna Klesh ³²

Kafi R Hemphill ³³

Jared Carlson Stevermer ³⁴

Jennifer Oki ³⁴

Kevin Holden ³⁴

Travis Maures ³⁴

Katherine Pollard ^{4, 35, 36}

Andrej Sali ^{1, 2, 14, 19}

David A. Agard ^{1, 2, 12, 37}

Yifan Cheng ^{1, 2, 12, 15, 37}

James M. Fraser ^{1, 2, 12, 19}

Adam Frost ^{1, 2, 12, 37}

Natalia Jura ^{1, 2, 3, 12, 38}

Tanja Kortemme ^{1, 2, 12, 19, 39}

Aashish Manglik ^{1, 2, 12, 14}

Robert M Stroud ^{1, 2, 12, 37}

Dario R. Alessi ³¹

P. Davies ³¹

Matthew Frieman ³⁰

Trey Ideker ^{29, 40}

Carmen Abate ²⁶

Nolwenn Jouvenet ^{27, 28}

Georg Kochs ²⁷

Brian Shoichet ^{1, 2, 14}

Melanie Ott ^{4, 41}

Massimo Palmarini ²³

Kevan M. Shokat ^{1, 2, 3, 15}

Adolfo García-Sastre ^{21, 22, 42, 43}

Jeremy A. Rassen ¹¹

Robert Grosse ^{9, 44}

Oren S. Rosenberg ^{1, 2, 12, 36, 37}

Klim Verba ^{1, 2, 12, 14}

Christopher F. Basler ¹⁰

Marco Vignuzzi ⁸

A. A. Peden ²⁰

Pedro Beltrao ¹⁶

Nevan J. Krogan ^{1, 2, 3, 4, 21}

Hide authors affiliations Show authors affiliations: 44 affiliations

Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA. |

QBI, University of California, San Francisco, CA 94158, USA. |

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA. |

⁴

J. David Gladstone Institutes, San Francisco, CA 94158, USA. |

⁵

Medical Scientist Training Program, University of California, San Francisco, CA 94143, USA. |

⁶

Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA. |

⁷

Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA. |

⁸

Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724, Paris, cedex 15, France. |

⁹

Institute for Clinical and Experimental Pharmacology and Toxicology I, University of Freiburg, 79104 Freiburg, Germany. |

¹⁰

Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. |

¹¹

Aetion, Inc., New York, NY 10001, USA. |

¹²

QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA. |

¹³

Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA. |

¹⁴

Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA. |

¹⁵

Howard Hughes Medical Institute, San Francisco, CA 94158, USA. |

¹⁶

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK. |

¹⁷

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. |

¹⁸

Beam Therapeutics, Cambridge, MA 02139, USA. |

¹⁹

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA. |

²⁰

Department of Biomedical Science, Centre for Membrane Interactions and Dynamics, University of Sheffield, Firth Court, Sheffield S10 2TN, UK. |

²¹

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. |

²²

Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. |

²³

MRC–University of Glasgow Centre for Virus Research, Glasgow G61 1QH, Scotland, UK. |

²⁴

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK. |

²⁵

Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK. |

²⁶

Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari ‘ALDO MORO’, Via Orabona, 4 70125, Bari, Italy. |

²⁷

Institute of Virology, Medical Center–University of Freiburg, 79104 Freiburg, Germany. |

²⁸

Département de Virologie, CNRS UMR 3569, Institut Pasteur, Paris 75015, France. |

²⁹

Department of Medicine, University of California, San Diego, CA 92093, USA. |

³⁰

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. |

³¹

MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. |

³²

HealthVerity, Philadelphia, PA 19103, USA. |

³³

Department of Neurology, University of California, San Francisco, CA 94143, USA. |

³⁴

Synthego Corporation, Redwood City, CA 94063, USA. |

³⁵

Department of Epidemiology & Biostatistics, University of California, San Francisco, CA 94158, USA. |

³⁶

Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA. |

³⁷

Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA. |

³⁸

Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA. |

³⁹

The University of California, Berkeley–University of California, San Francisco Graduate Program in Bioengineering, University of California, San Francisco, CA 94158, USA.

University of California, Berkeley

University of California, San Francisco

⁴⁰

Department to Bioengineering, University of California, San Diego, CA 92093, USA. |

⁴¹

Department of Medicine, University of California, San Francisco, CA 94143, USA. |

⁴²

Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. |

⁴³

The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. |

⁴⁴

Centre for Integrative Biological Signaling Studies (CIBSS), University of Freiburg, 79104 Freiburg, Germany. |

Publication type: Journal Article

Publication date: 2020-12-04

American Association for the Advancement of Science (AAAS)

Science

scimago Q1

wos Q1

SJR: 10.416

CiteScore: 48.4

Impact factor: 45.8

ISSN: 00368075, 10959203

DOI: 10.1126/science.abe9403

Copy DOI

PubMed ID: 33060197

Multidisciplinary

Abstract

How lethal coronaviruses engage hosts

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is closely related to the deadly coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Considerable efforts are focused on developing treatments, and therapies that work across coronaviruses would be particularly valuable. Shedding light on the host factors hijacked by the viruses, Gordon et al. mapped the interactions between viral and human proteins for SARS-CoV-2, SARS-CoV-1, and MERS-CoV; analyzed the localization of viral proteins in human cells; and used genetic screening to identify host factors that either enhance or inhibit viral infection. For a subset of the interactions essential for the virus life cycle, the authors determined the cryo–electron microscopy structures and mined patient data to understand how targeting host factors may be relevant to clinical outcomes.

Science , this issue p. eabe9403

Found

3 citations

Roviello Giovanni

🥼 🤝

150 publications, 3 198 citations

h-index: 30

Institute of Biostructure and Bioimaging

Research interests

Biomedicine

Computational chemistry

DNA

RNA

1 citation

Stepanic Visnja

🥼 🤝

55 publications, 1 684 citations, 59 reviews

h-index: 23

Ruđer Bošković Institute

Research interests

Bioinformatics

Medicinal Chemistry

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Gordon I. E. et al. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms // Science. 2020. Vol. 370. No. 6521.

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Gordon I. E. et al. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms // Science. 2020. Vol. 370. No. 6521.

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BibTex (up to 50 authors) Copy

@article{2020_Gordon,

author = {Iouli E Gordon and Joseph Hiatt and Mehdi Bouhaddou and Veronica V Rezelj and Svenja Ulferts and Hannes Braberg and Alexander S Jureka and Kirsten Obernier and Jeffrey Z Guo and Jyoti Batra and Robyn M Kaake and Andrew Weckstein and Tristan W Owens and Meghna Gupta and Sergei Pourmal and Erron W. Titus and Merve Cakir and Margaret Soucheray and Michael Michael N. McGregor and Zeynep Cakir and Gwendolyn M. Jang and Matthew J Omeara and Tia A Tummino and Ziyang Zhang and Hélène Foussard and Ajda Rojc and Yuan Zhou and Dmitry Kuchenov and Ruth Hüttenhain and Jiewei Xu and Manon Eckhardt and Danielle Swaney and Jacqueline M Fabius and Manisha Ummadi and Beril Tutuncuoglu and Ujjwal Rathore and Maya Modak and P Haas and Kelsey M Haas and Zun Zar Chi Naing and Ernst H. Pulido and Ying Shi and Inigo Barrio-Hernandez and Danish Memon and Eirini Petsalaki and Alistair S. Dunham and Miguel Correa Marrero and David F. Burke and Cassandra Koh and Thomas Vallet and others},

title = {Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms},

journal = {Science},

year = {2020},

volume = {370},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {dec},

url = {https://doi.org/10.1126/science.abe9403},

number = {6521},

doi = {10.1126/science.abe9403}

}

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science

scimago Q1

wos Q1

SJR

10.416

CiteScore

48.4

Impact factor

45.8

ISSN

00368075 (Print)

10959203 (Electronic)

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