Open Access
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
Тип публикации: Journal Article
Дата публикации: 2020-12-04
SCImago Q1
Tоп 10% SCImago
WOS Q1
БС1
SJR: 10.948
CiteScore: 44.6
Impact factor: 47.3
ISSN: 00368075, 10959203
PubMed ID:
33060197
Multidisciplinary
Краткое описание
How lethal coronaviruses engage hosts
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is closely related to the deadly coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Considerable efforts are focused on developing treatments, and therapies that work across coronaviruses would be particularly valuable. Shedding light on the host factors hijacked by the viruses, Gordon et al. mapped the interactions between viral and human proteins for SARS-CoV-2, SARS-CoV-1, and MERS-CoV; analyzed the localization of viral proteins in human cells; and used genetic screening to identify host factors that either enhance or inhibit viral infection. For a subset of the interactions essential for the virus life cycle, the authors determined the cryo–electron microscopy structures and mined patient data to understand how targeting host factors may be relevant to clinical outcomes.
Science
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656
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Gordon I. E. et al. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms // Science. 2020. Vol. 370. No. 6521.
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Gordon I. E. et al. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms // Science. 2020. Vol. 370. No. 6521.
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@article{2020_Gordon,
author = {Iouli E Gordon and Joseph Hiatt and Mehdi Bouhaddou and Veronica V Rezelj and Svenja Ulferts and Hannes Braberg and Alexander S Jureka and Kirsten Obernier and Jeffrey Z Guo and Jyoti Batra and Robyn M Kaake and Andrew Weckstein and Tristan W Owens and Meghna Gupta and Sergei Pourmal and Erron W. Titus and Merve Cakir and Margaret Soucheray and Michael Michael N. McGregor and Zeynep Cakir and Gwendolyn M. Jang and Matthew J Omeara and Tia A Tummino and Ziyang Zhang and Hélène Foussard and Ajda Rojc and Yuan Zhou and Dmitry Kuchenov and Ruth Hüttenhain and Jiewei Xu and Manon Eckhardt and Danielle Swaney and Jacqueline M Fabius and Manisha Ummadi and Beril Tutuncuoglu and Ujjwal Rathore and Maya Modak and P Haas and Kelsey M Haas and Zun Zar Chi Naing and Ernst H. Pulido and Ying Shi and Inigo Barrio-Hernandez and Danish Memon and Eirini Petsalaki and Alistair S. Dunham and Miguel Correa Marrero and David F. Burke and Cassandra Koh and Thomas Vallet and others},
title = {Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms},
journal = {Science},
year = {2020},
volume = {370},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {dec},
url = {https://doi.org/10.1126/science.abe9403},
number = {6521},
doi = {10.1126/science.abe9403}
}
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