Open Access
Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates
Тип публикации: Journal Article
Дата публикации: 2021-09-17
scimago Q1
wos Q1
БС1
SJR: 10.416
CiteScore: 48.4
Impact factor: 45.8
ISSN: 00368075, 10959203
PubMed ID:
34529476
Multidisciplinary
Краткое описание
Antibodies dovetail with protection
Immune correlates of protection are clinical end points used to gauge vaccine-induced immunogenicity and protection. Corbett et al . studied nonhuman primate (NHP) immune responses to various doses of the mRNA-1273 (Moderna) vaccine to provide a range of immune responses and protective outcomes. They determined that circulating spike protein–specific antibodies correlated with protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in the airways. Passively transferred NHP antibodies were sufficient to mediate protection against SARS-CoV-2 challenge in hamsters, emphasizing that antibodies are mechanistic correlates. Protection of the lower respiratory tract required lower serum antibody concentrations, possibly explaining why most current vaccines are highly effective against severe lower airway disease. The higher antibody threshold required for reducing upper airway infection has potential implications for boosting to limit transmission. —STS
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ГОСТ |
RIS |
BibTex
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ГОСТ
Скопировать
Corbett K. S. et al. Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates // Science. 2021. Vol. 373. No. 6561.
ГОСТ со всеми авторами (до 50)
Скопировать
Corbett K. S. et al. Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates // Science. 2021. Vol. 373. No. 6561.
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RIS
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TY - JOUR
DO - 10.1126/science.abj0299
UR - https://doi.org/10.1126/science.abj0299
TI - Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates
T2 - Science
AU - Corbett, Kizzmekia S.
AU - Nason, M.
AU - Flach, Britta
AU - Gagne, Matthew
AU - O’Connell, Sarah
AU - Johnston, Matthew S
AU - Shah, Hairol Nizam Mohd
AU - Edara, Venkata Viswanadh
AU - Floyd, Katharine
AU - Lai, Lilin
AU - McDanal, Charlene
AU - Francica, Joseph R.
AU - Flynn, Barbara
AU - Wu, Kai
AU - Choi, Angela
AU - Koch, Matthew
AU - Abiona, Olubukola M.
AU - Werner, Anne P
AU - Moliva, Juan I.
AU - Andrew, Shayne F
AU - Donaldson, Mitzi M.
AU - Fintzi, Jonathan
AU - Flebbe, Dillon R.
AU - Lamb, Evan
AU - Noe, Amy T.
AU - Nurmukhambetova, Saule T
AU - Provost, Samantha J
AU - Cook, Anthony
AU - Dodson, Alan
AU - Faudree, Andrew
AU - Greenhouse, Jack
AU - Kar, Swagata
AU - Pessaint, Laurent
AU - Porto, Maciel
AU - Steingrebe, Katelyn
AU - Valentin, Daniel
AU - Zouantcha, Serge
AU - Bock, Kevin R.
AU - Minai, Mahnaz
AU - Nagata, Bianca M.
AU - van de Wetering, R.A.C.
AU - Boyoglu-Barnum, Seyhan
AU - Leung, Kwanyee
AU - Shi, Wei
AU - Yang, Eun-Sung
AU - Zhang, Yi
AU - Todd, John-Paul M.
AU - Wang, Lingshu
AU - Alvarado, Gabriela S
AU - Andersen, Hanne
AU - Foulds, Kathryn E.
AU - Edwards, Darin K
AU - Mascola, John
AU - Moore, Ian N
AU - Lewis, Mark G.
AU - Carfi, Andrea
AU - Montefiori, David C.
AU - Suthar, Mehul S.
AU - McDermott, Adrian B.
AU - Roederer, Mario
AU - Sullivan, Nancy J
AU - Douek, Daniel C.
AU - Graham, B.
AU - Seder, Robert A.
PY - 2021
DA - 2021/09/17
PB - American Association for the Advancement of Science (AAAS)
IS - 6561
VL - 373
PMID - 34529476
SN - 0036-8075
SN - 1095-9203
ER -
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BibTex (до 50 авторов)
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@article{2021_Corbett,
author = {Kizzmekia S. Corbett and M. Nason and Britta Flach and Matthew Gagne and Sarah O’Connell and Matthew S Johnston and Hairol Nizam Mohd Shah and Venkata Viswanadh Edara and Katharine Floyd and Lilin Lai and Charlene McDanal and Joseph R. Francica and Barbara Flynn and Kai Wu and Angela Choi and Matthew Koch and Olubukola M. Abiona and Anne P Werner and Juan I. Moliva and Shayne F Andrew and Mitzi M. Donaldson and Jonathan Fintzi and Dillon R. Flebbe and Evan Lamb and Amy T. Noe and Saule T Nurmukhambetova and Samantha J Provost and Anthony Cook and Alan Dodson and Andrew Faudree and Jack Greenhouse and Swagata Kar and Laurent Pessaint and Maciel Porto and Katelyn Steingrebe and Daniel Valentin and Serge Zouantcha and Kevin R. Bock and Mahnaz Minai and Bianca M. Nagata and R.A.C. van de Wetering and Seyhan Boyoglu-Barnum and Kwanyee Leung and Wei Shi and Eun-Sung Yang and Yi Zhang and John-Paul M. Todd and Lingshu Wang and Gabriela S Alvarado and Hanne Andersen and others},
title = {Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates},
journal = {Science},
year = {2021},
volume = {373},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {sep},
url = {https://doi.org/10.1126/science.abj0299},
number = {6561},
doi = {10.1126/science.abj0299}
}