Open Access

Science

, volume 373 , issue 6561

Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates

Kizzmekia S. Corbett ¹

M. Nason ²

Britta Flach ¹

Matthew Gagne ¹

Sarah O’Connell ¹

Matthew S Johnston ¹

Hairol Nizam Mohd Shah ¹

Venkata Viswanadh Edara ³

Katharine Floyd ³

Lilin Lai ³

Charlene McDanal ⁴

Joseph R. Francica ¹

Barbara Flynn ¹

Kai Wu ⁵

Angela Choi ⁵

Matthew Koch ⁵

Olubukola M. Abiona ¹

Anne P Werner ¹

Juan I. Moliva ¹

Shayne F Andrew ¹

Mitzi M. Donaldson ¹

Jonathan Fintzi ¹

Dillon R. Flebbe ¹

Evan Lamb ¹

Amy T. Noe ¹

Saule T Nurmukhambetova ¹

Samantha J Provost ¹

Anthony Cook ⁶

Alan Dodson ⁶

Andrew Faudree ⁶

Jack Greenhouse ⁶

Swagata Kar ⁶

Laurent Pessaint ⁶

Maciel Porto ⁶

Katelyn Steingrebe ⁶

Daniel Valentin ⁶

Serge Zouantcha ⁶

Kevin R. Bock ⁷

Mahnaz Minai ⁷

Bianca M. Nagata ⁷

R.A.C. van de Wetering ¹

Seyhan Boyoglu-Barnum ¹

Kwanyee Leung ¹

Wei Shi ¹

Eun-Sung Yang ¹

Yi Zhang ¹

John-Paul M. Todd ¹

Lingshu Wang ¹

Gabriela S Alvarado ¹

Hanne Andersen ⁶

Kathryn E. Foulds ¹

Darin K Edwards ⁵

John Mascola ¹

Ian N Moore ⁷

Mark G. Lewis ⁶

Andrea Carfi ⁵

David C. Montefiori ⁴

Mehul S. Suthar ^{3, 8}

Adrian B. McDermott ¹

Mario Roederer ¹

Nancy J Sullivan ¹

Daniel C. Douek ¹

B. Graham ¹

Robert A. Seder ¹

Hide authors affiliations Show authors affiliations: 8 affiliations

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. |

Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. |

Center for Childhood Infections and Vaccines of Children’s Healthcare of Atlanta, Department of Pediatrics, Department of Microbiology and Immunology, Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA. |

⁴

Department of Surgery, Duke University Medical Center, Durham, NC 27708, USA. |

⁵

Moderna Inc., Cambridge, MA 02139, USA. |

⁶

BIOQUAL Inc., Rockville, MD 20850, USA. |

⁷

Infectious Disease Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. |

⁸

Department of Microbiology and Immunology, Atlanta, GA 30329, USA. |

Publication type: Journal Article

Publication date: 2021-09-17

American Association for the Advancement of Science (AAAS)

Science

scimago Q1

wos Q1

SJR: 10.416

CiteScore: 48.4

Impact factor: 45.8

ISSN: 00368075, 10959203

DOI: 10.1126/science.abj0299

Copy DOI

PubMed ID: 34529476

Multidisciplinary

Abstract

Antibodies dovetail with protection

Immune correlates of protection are clinical end points used to gauge vaccine-induced immunogenicity and protection. Corbett et al . studied nonhuman primate (NHP) immune responses to various doses of the mRNA-1273 (Moderna) vaccine to provide a range of immune responses and protective outcomes. They determined that circulating spike protein–specific antibodies correlated with protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in the airways. Passively transferred NHP antibodies were sufficient to mediate protection against SARS-CoV-2 challenge in hamsters, emphasizing that antibodies are mechanistic correlates. Protection of the lower respiratory tract required lower serum antibody concentrations, possibly explaining why most current vaccines are highly effective against severe lower airway disease. The higher antibody threshold required for reducing upper airway infection has potential implications for boosting to limit transmission. —STS

Found

1 citation

Erbs Gitte

26 publications, 2 134 citations

h-index: 16

Statens Serum Institut

Top-30

Journals

	2 4 6 8 10 12 14 16 18
bioRxiv	bioRxiv, 17, 6.49% bioRxiv 17 publications, 6.49%
Nature Communications	Nature Communications, 15, 5.73% Nature Communications 15 publications, 5.73%
Frontiers in Immunology	Frontiers in Immunology, 13, 4.96% Frontiers in Immunology 13 publications, 4.96%
npj Vaccines	npj Vaccines, 11, 4.2% npj Vaccines 11 publications, 4.2%
Cell	Cell, 10, 3.82% Cell 10 publications, 3.82%
Science Translational Medicine	Science Translational Medicine, 8, 3.05% Science Translational Medicine 8 publications, 3.05%
Vaccines	Vaccines, 7, 2.67% Vaccines 7 publications, 2.67%
Science	Science, 5, 1.91% Science 5 publications, 1.91%
Viruses	Viruses, 5, 1.91% Viruses 5 publications, 1.91%
EBioMedicine	EBioMedicine, 5, 1.91% EBioMedicine 5 publications, 1.91%
Vaccine	Vaccine, 5, 1.91% Vaccine 5 publications, 1.91%
Immunity	Immunity, 4, 1.53% Immunity 4 publications, 1.53%
iScience	iScience, 4, 1.53% iScience 4 publications, 1.53%
PLoS Pathogens	PLoS Pathogens, 4, 1.53% PLoS Pathogens 4 publications, 1.53%
Science advances	Science advances, 4, 1.53% Science advances 4 publications, 1.53%
Science immunology	Science immunology, 4, 1.53% Science immunology 4 publications, 1.53%
Clinical Infectious Diseases	Clinical Infectious Diseases, 4, 1.53% Clinical Infectious Diseases 4 publications, 1.53%
JCI insight	JCI insight, 3, 1.15% JCI insight 3 publications, 1.15%
Nature Immunology	Nature Immunology, 3, 1.15% Nature Immunology 3 publications, 1.15%
Human Vaccines and Immunotherapeutics	Human Vaccines and Immunotherapeutics, 3, 1.15% Human Vaccines and Immunotherapeutics 3 publications, 1.15%
Open Forum Infectious Diseases	Open Forum Infectious Diseases, 3, 1.15% Open Forum Infectious Diseases 3 publications, 1.15%
Journal of Infectious Diseases	Journal of Infectious Diseases, 3, 1.15% Journal of Infectious Diseases 3 publications, 1.15%
Microbiology spectrum	Microbiology spectrum, 3, 1.15% Microbiology spectrum 3 publications, 1.15%
Microorganisms	Microorganisms, 2, 0.76% Microorganisms 2 publications, 0.76%
Nature Microbiology	Nature Microbiology, 2, 0.76% Nature Microbiology 2 publications, 0.76%
Signal Transduction and Targeted Therapy	Signal Transduction and Targeted Therapy, 2, 0.76% Signal Transduction and Targeted Therapy 2 publications, 0.76%
Nature Medicine	Nature Medicine, 2, 0.76% Nature Medicine 2 publications, 0.76%
Antiviral Research	Antiviral Research, 2, 0.76% Antiviral Research 2 publications, 0.76%
PLoS ONE	PLoS ONE, 2, 0.76% PLoS ONE 2 publications, 0.76%
	2 4 6 8 10 12 14 16 18

Publishers

	10 20 30 40 50 60
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 54, 20.61% Cold Spring Harbor Laboratory 54 publications, 20.61%
Elsevier	Elsevier, 46, 17.56% Elsevier 46 publications, 17.56%
Springer Nature	Springer Nature, 44, 16.79% Springer Nature 44 publications, 16.79%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 21, 8.02% American Association for the Advancement of Science (AAAS) 21 publications, 8.02%
Frontiers Media S.A.	Frontiers Media S.A., 16, 6.11% Frontiers Media S.A. 16 publications, 6.11%
MDPI	MDPI, 16, 6.11% MDPI 16 publications, 6.11%
Wiley	Wiley, 13, 4.96% Wiley 13 publications, 4.96%
Oxford University Press	Oxford University Press, 11, 4.2% Oxford University Press 11 publications, 4.2%
American Society for Microbiology	American Society for Microbiology, 9, 3.44% American Society for Microbiology 9 publications, 3.44%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 6, 2.29% Public Library of Science (PLoS) 6 publications, 2.29%
American Society for Clinical Investigation	American Society for Clinical Investigation, 4, 1.53% American Society for Clinical Investigation 4 publications, 1.53%
Taylor & Francis	Taylor & Francis, 4, 1.53% Taylor & Francis 4 publications, 1.53%
SAGE	SAGE, 3, 1.15% SAGE 3 publications, 1.15%
American College of Physicians	American College of Physicians, 1, 0.38% American College of Physicians 1 publication, 0.38%
Massachusetts Medical Society	Massachusetts Medical Society, 1, 0.38% Massachusetts Medical Society 1 publication, 0.38%
Ovid Technologies (Wolters Kluwer Health)	Ovid Technologies (Wolters Kluwer Health), 1, 0.38% Ovid Technologies (Wolters Kluwer Health) 1 publication, 0.38%
American Chemical Society (ACS)	American Chemical Society (ACS), 1, 0.38% American Chemical Society (ACS) 1 publication, 0.38%
The American Association of Immunologists	The American Association of Immunologists, 1, 0.38% The American Association of Immunologists 1 publication, 0.38%
BMJ	BMJ, 1, 0.38% BMJ 1 publication, 0.38%
American Society of Hematology	American Society of Hematology, 1, 0.38% American Society of Hematology 1 publication, 0.38%
American Society of Clinical Oncology (ASCO)	American Society of Clinical Oncology (ASCO), 1, 0.38% American Society of Clinical Oncology (ASCO) 1 publication, 0.38%
Annual Reviews	Annual Reviews, 1, 0.38% Annual Reviews 1 publication, 0.38%
American Society for Cell Biology (ASCB)	American Society for Cell Biology (ASCB), 1, 0.38% American Society for Cell Biology (ASCB) 1 publication, 0.38%
Research Square Platform LLC	Research Square Platform LLC, 1, 0.38% Research Square Platform LLC 1 publication, 0.38%
Cambridge University Press	Cambridge University Press, 1, 0.38% Cambridge University Press 1 publication, 0.38%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 0.38% Royal Society of Chemistry (RSC) 1 publication, 0.38%
	10 20 30 40 50 60

We do not take into account publications without a DOI.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

PDF

Metrics

263

Cite this

GOST |

Cite this

GOST Copy

Corbett K. S. et al. Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates // Science. 2021. Vol. 373. No. 6561.

GOST all authors (up to 50) Copy

Corbett K. S. et al. Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates // Science. 2021. Vol. 373. No. 6561.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1126/science.abj0299

UR - https://doi.org/10.1126/science.abj0299

TI - Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates

T2 - Science

AU - Corbett, Kizzmekia S.

AU - Nason, M.

AU - Flach, Britta

AU - Gagne, Matthew

AU - O’Connell, Sarah

AU - Johnston, Matthew S

AU - Shah, Hairol Nizam Mohd

AU - Edara, Venkata Viswanadh

AU - Floyd, Katharine

AU - Lai, Lilin

AU - McDanal, Charlene

AU - Francica, Joseph R.

AU - Flynn, Barbara

AU - Wu, Kai

AU - Choi, Angela

AU - Koch, Matthew

AU - Abiona, Olubukola M.

AU - Werner, Anne P

AU - Moliva, Juan I.

AU - Andrew, Shayne F

AU - Donaldson, Mitzi M.

AU - Fintzi, Jonathan

AU - Flebbe, Dillon R.

AU - Lamb, Evan

AU - Noe, Amy T.

AU - Nurmukhambetova, Saule T

AU - Provost, Samantha J

AU - Cook, Anthony

AU - Dodson, Alan

AU - Faudree, Andrew

AU - Greenhouse, Jack

AU - Kar, Swagata

AU - Pessaint, Laurent

AU - Porto, Maciel

AU - Steingrebe, Katelyn

AU - Valentin, Daniel

AU - Zouantcha, Serge

AU - Bock, Kevin R.

AU - Minai, Mahnaz

AU - Nagata, Bianca M.

AU - van de Wetering, R.A.C.

AU - Boyoglu-Barnum, Seyhan

AU - Leung, Kwanyee

AU - Shi, Wei

AU - Yang, Eun-Sung

AU - Zhang, Yi

AU - Todd, John-Paul M.

AU - Wang, Lingshu

AU - Alvarado, Gabriela S

AU - Andersen, Hanne

AU - Foulds, Kathryn E.

AU - Edwards, Darin K

AU - Mascola, John

AU - Moore, Ian N

AU - Lewis, Mark G.

AU - Carfi, Andrea

AU - Montefiori, David C.

AU - Suthar, Mehul S.

AU - McDermott, Adrian B.

AU - Roederer, Mario

AU - Sullivan, Nancy J

AU - Douek, Daniel C.

AU - Graham, B.

AU - Seder, Robert A.

PY - 2021

DA - 2021/09/17

PB - American Association for the Advancement of Science (AAAS)

IS - 6561

VL - 373

PMID - 34529476

SN - 0036-8075

SN - 1095-9203

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2021_Corbett,

author = {Kizzmekia S. Corbett and M. Nason and Britta Flach and Matthew Gagne and Sarah O’Connell and Matthew S Johnston and Hairol Nizam Mohd Shah and Venkata Viswanadh Edara and Katharine Floyd and Lilin Lai and Charlene McDanal and Joseph R. Francica and Barbara Flynn and Kai Wu and Angela Choi and Matthew Koch and Olubukola M. Abiona and Anne P Werner and Juan I. Moliva and Shayne F Andrew and Mitzi M. Donaldson and Jonathan Fintzi and Dillon R. Flebbe and Evan Lamb and Amy T. Noe and Saule T Nurmukhambetova and Samantha J Provost and Anthony Cook and Alan Dodson and Andrew Faudree and Jack Greenhouse and Swagata Kar and Laurent Pessaint and Maciel Porto and Katelyn Steingrebe and Daniel Valentin and Serge Zouantcha and Kevin R. Bock and Mahnaz Minai and Bianca M. Nagata and R.A.C. van de Wetering and Seyhan Boyoglu-Barnum and Kwanyee Leung and Wei Shi and Eun-Sung Yang and Yi Zhang and John-Paul M. Todd and Lingshu Wang and Gabriela S Alvarado and Hanne Andersen and others},

title = {Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates},

journal = {Science},

year = {2021},

volume = {373},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {sep},

url = {https://doi.org/10.1126/science.abj0299},

number = {6561},

doi = {10.1126/science.abj0299}

}

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science

scimago Q1

wos Q1

SJR

10.416

CiteScore

48.4

Impact factor

45.8

ISSN

00368075 (Print)

10959203 (Electronic)

Profiles