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, том 375 , издание 6576 , страницы 43-50

Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial

Тип публикации: Journal Article

Дата публикации: 2022-01-07

American Association for the Advancement of Science (AAAS)

Science

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SJR: 10.416

CiteScore: 48.4

Impact factor: 45.8

ISSN: 00368075, 10959203

DOI: 10.1126/science.abm3425

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PubMed ID: 34812653

Multidisciplinary

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Antibody levels predict vaccine efficacy

Symptomatic COVID-19 infection can be prevented by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines. A “correlate of protection” is a molecular biomarker to measure how much immunity is needed to fight infection and is key for successful global immunization programs. Gilbert et al . determined that antibodies are the correlate of protection in vaccinated individuals enrolled in the Moderna COVE phase 3 clinical trial (see the Perspective by Openshaw). By measuring binding and neutralizing antibodies against the viral spike protein, the authors found that the levels of both antibodies correlated with the degree of vaccine efficacy. The higher the antibody level, the greater the protection afforded by the messenger RNA (mRNA) vaccine. Antibody levels that predict mRNA vaccine efficacy can therefore be used to guide vaccine regimen modifications and support regulatory approvals for a broader spectrum of the population. —PNK

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Gilbert P. G. et al. Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial // Science. 2022. Vol. 375. No. 6576. pp. 43-50.

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Gilbert P. G., Montefiori D. C., McDermott A. B., Fong Y., Benkeser D., Deng W., Zhou H., Houchens C. R., Martins K. J., Jayashankar L., Castellino F., Flach B., Lin B. C., O’Connell S., McDanal C., Eaton A. J., Sarzotti-Kelsoe M., Lu Y., Yu C., Borate B., van der Laan L. W. P., Hejazi N. S., Chuong H., Miller J., El Sahly H. M., Baden L. R., Baron M., de la Cruz L., Gay C., Kalams S., Kelley C. F., Andrasik M. P., Kublin J. G., Corey L., Neuzil K. M., Carpp L. N., Pajon R., Follmann D., Donis R. O., Koup R. A. Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial // Science. 2022. Vol. 375. No. 6576. pp. 43-50.

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TY - JOUR

DO - 10.1126/science.abm3425

UR - https://doi.org/10.1126/science.abm3425

TI - Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial

T2 - Science

AU - Gilbert, Peter G.

AU - Montefiori, David C.

AU - McDermott, Adrian B.

AU - Fong, Youyi

AU - Benkeser, David

AU - Deng, Weiping

AU - Zhou, Honghong

AU - Houchens, Christopher R

AU - Martins, Karen J.B.

AU - Jayashankar, Lakshmi

AU - Castellino, Flora

AU - Flach, Britta

AU - Lin, Bob C

AU - O’Connell, Sarah

AU - McDanal, Charlene

AU - Eaton, Amanda J.

AU - Sarzotti-Kelsoe, Marcella

AU - Lu, Yiwen

AU - Yu, Chenchen

AU - Borate, Bhavesh

AU - van der Laan, Lars W. P.

AU - Hejazi, Nima S.

AU - Chuong, Huynh

AU - Miller, Jacqueline

AU - El Sahly, Hana M

AU - Baden, Lindsey R.

AU - Baron, Mira

AU - de la Cruz, Luis

AU - Gay, Cynthia

AU - Kalams, Spyros

AU - Kelley, Colleen F.

AU - Andrasik, Michele P

AU - Kublin, James G

AU - Corey, Lawrence

AU - Neuzil, Kathleen M.

AU - Carpp, Lindsay N.

AU - Pajon, Rolando

AU - Follmann, Dean

AU - Donis, Ruben O

AU - Koup, Richard A.

PY - 2022

DA - 2022/01/07

PB - American Association for the Advancement of Science (AAAS)

SP - 43-50

IS - 6576

VL - 375

PMID - 34812653

SN - 0036-8075

SN - 1095-9203

ER -

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@article{2022_Gilbert,

author = {Peter G. Gilbert and David C. Montefiori and Adrian B. McDermott and Youyi Fong and David Benkeser and Weiping Deng and Honghong Zhou and Christopher R Houchens and Karen J.B. Martins and Lakshmi Jayashankar and Flora Castellino and Britta Flach and Bob C Lin and Sarah O’Connell and Charlene McDanal and Amanda J. Eaton and Marcella Sarzotti-Kelsoe and Yiwen Lu and Chenchen Yu and Bhavesh Borate and Lars W. P. van der Laan and Nima S. Hejazi and Huynh Chuong and Jacqueline Miller and Hana M El Sahly and Lindsey R. Baden and Mira Baron and Luis de la Cruz and Cynthia Gay and Spyros Kalams and Colleen F. Kelley and Michele P Andrasik and James G Kublin and Lawrence Corey and Kathleen M. Neuzil and Lindsay N. Carpp and Rolando Pajon and Dean Follmann and Ruben O Donis and Richard A. Koup},

title = {Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial},

journal = {Science},

year = {2022},

volume = {375},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {jan},

url = {https://doi.org/10.1126/science.abm3425},

number = {6576},

pages = {43--50},

doi = {10.1126/science.abm3425}

}

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Gilbert, Peter G., et al. “Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial.” Science, vol. 375, no. 6576, Jan. 2022, pp. 43-50. https://doi.org/10.1126/science.abm3425.