An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
Timothy P. Sheahan
1
,
Amy R. Sims
1
,
Shuntai Zhou
2
,
Rachel L Graham
1
,
Andrea J Pruijssers
3
,
Maria L Agostini
3
,
Sarah R. Leist
1
,
Alexandra Schäfer
1
,
Kenneth H Dinnon Iii
1, 4
,
Laura J Stevens
3
,
James D. Chappell
3
,
Xiaotao Lu
3
,
Tia M Hughes
3
,
Amelia S George
3
,
Collin S Hill
2
,
Stephanie Montgomery
5
,
Ariane J Brown
1
,
Gregory R Bluemling
6, 7
,
Michael G Natchus
6
,
Manohar Saindane
6
,
Alexander A Kolykhalov
6, 7
,
George R. Painter
6, 7, 8
,
Jennifer L. Harcourt
9
,
Azaibi Tamin
9
,
Natalie J. Thornburg
9
,
Ronald Swanstrom
2, 10
,
MARK DENISON
3
,
Ralph Baric
1, 4
1
7
Drug Innovation Ventures at Emory (DRIVE), Atlanta, GA 30322, USA.
|
Publication type: Journal Article
Publication date: 2020-04-29
scimago Q1
wos Q1
SJR: 6.722
CiteScore: 27.9
Impact factor: 14.6
ISSN: 19466234, 19466242
PubMed ID:
32253226
General Medicine
Abstract
A ribonucleoside analog inhibits SARS-CoV-2 in human airway epithelial cell cultures and SARS-CoV and MERS-CoV in mice.
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Total citations:
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GOST
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Sheahan T. P. et al. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice // Science Translational Medicine. 2020. Vol. 12. No. 541.
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Sheahan T. P., Sims A. R., Zhou S., Graham R. L., Pruijssers A. J., Agostini M. L., Leist S. R., Schäfer A., Dinnon Iii K. H., Stevens L. J., Chappell J. D., Lu X., Hughes T. M., George A. S., Hill C. S., Montgomery S., Brown A. J., Bluemling G. R., Natchus M. G., Saindane M., Kolykhalov A. A., Painter G. R., Harcourt J. L., Tamin A., Thornburg N. J., Swanstrom R., DENISON M., Baric R. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice // Science Translational Medicine. 2020. Vol. 12. No. 541.
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RIS
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TY - JOUR
DO - 10.1126/scitranslmed.abb5883
UR - https://doi.org/10.1126/scitranslmed.abb5883
TI - An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
T2 - Science Translational Medicine
AU - Sheahan, Timothy P.
AU - Sims, Amy R.
AU - Zhou, Shuntai
AU - Graham, Rachel L
AU - Pruijssers, Andrea J
AU - Agostini, Maria L
AU - Leist, Sarah R.
AU - Schäfer, Alexandra
AU - Dinnon Iii, Kenneth H
AU - Stevens, Laura J
AU - Chappell, James D.
AU - Lu, Xiaotao
AU - Hughes, Tia M
AU - George, Amelia S
AU - Hill, Collin S
AU - Montgomery, Stephanie
AU - Brown, Ariane J
AU - Bluemling, Gregory R
AU - Natchus, Michael G
AU - Saindane, Manohar
AU - Kolykhalov, Alexander A
AU - Painter, George R.
AU - Harcourt, Jennifer L.
AU - Tamin, Azaibi
AU - Thornburg, Natalie J.
AU - Swanstrom, Ronald
AU - DENISON, MARK
AU - Baric, Ralph
PY - 2020
DA - 2020/04/29
PB - American Association for the Advancement of Science (AAAS)
IS - 541
VL - 12
PMID - 32253226
SN - 1946-6234
SN - 1946-6242
ER -
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@article{2020_Sheahan,
author = {Timothy P. Sheahan and Amy R. Sims and Shuntai Zhou and Rachel L Graham and Andrea J Pruijssers and Maria L Agostini and Sarah R. Leist and Alexandra Schäfer and Kenneth H Dinnon Iii and Laura J Stevens and James D. Chappell and Xiaotao Lu and Tia M Hughes and Amelia S George and Collin S Hill and Stephanie Montgomery and Ariane J Brown and Gregory R Bluemling and Michael G Natchus and Manohar Saindane and Alexander A Kolykhalov and George R. Painter and Jennifer L. Harcourt and Azaibi Tamin and Natalie J. Thornburg and Ronald Swanstrom and MARK DENISON and Ralph Baric},
title = {An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice},
journal = {Science Translational Medicine},
year = {2020},
volume = {12},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {apr},
url = {https://doi.org/10.1126/scitranslmed.abb5883},
number = {541},
doi = {10.1126/scitranslmed.abb5883}
}