Antimicrobial Agents and Chemotherapy, volume 56, issue 7, pages 3984-3985

In Vitro Activities of the New Antitubercular Agents PA-824 and BTZ043 against Nocardia brasiliensis

Lucio Vera-Cabrera 1
Mayra Paola Campos Rivera 1
Norma Alejandra González Martínez 1
Jorge Ocampo-Candiani 1
Stewart T Cole 2
1
 
Laboratorio Interdisciplinario de Investigación Dermatológica, Servicio de Dermatología, Hospital Universitario, Monterrey, N.L., Mexico
Publication typeJournal Article
Publication date2012-07-09
scimago Q1
SJR1.357
CiteScore10.0
Impact factor4.1
ISSN00664804, 10986596
PubMed ID:  22526312
Pharmacology
Infectious Diseases
Pharmacology (medical)
Abstract
ABSTRACT

The in vitro activity of PA-824 and BTZ043 against 30 Nocardia brasiliensis isolates was tested. The MIC 50 and MIC 90 values for PA-824 were both >64 μg/ml. The same values for BTZ043 were 0.125 and 0.250 μg/ml. Given the MIC values for benzothiazinone (BTZ) compounds, we consider them good candidates to be tested in vivo against N. brasiliensis .

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