Neuropilin-1 Mediates SARS-CoV-2 Infection of Astrocytes in Brain Organoids, Inducing Inflammation Leading to Dysfunction and Death of Neurons

Weili Kong ^{1, 2}

Mauricio Montano ^{1, 2}

Michael J. Corley ³

Ekram Helmy ^{1, 2}

Hirofumi Kobayashi ⁴

Martin Kinisu ^{1, 2}

Rahul Suryawanshi ²

Xiaoyu Luo ^{1, 2}

Loic A Royer ⁴

Nadia R. Roan ^{1, 2, 5}

Melanie Ott ^{1, 2, 6, 7}

Lishomwa C. Ndhlovu ³

Warner C. Greene ^{1, 2, 6, 7}

Show full list: 13 authors

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Michael Hulton Center for HIV Cure Research at Gladstone, San Francisco, California, USA |

Gladstone Institute of Virology, San Francisco, California, USA |

Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, New York, USA |

⁴

CZ Biohub, San Francisco, California, USA |

⁵

Department of Urology, University of California, San Francisco, San Francisco, California, USA |

⁶

Department of Medicine, University of California, San Francisco, San Francisco, California, USA |

⁷

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, USA |

Publication type: Journal Article

Publication date: 2022-10-31

American Society for Microbiology

Journal: mBio

scimago Q1

SJR: 2.028

CiteScore: 10.5

Impact factor: 5.1

ISSN: 21612129, 21507511

DOI: 10.1128/mbio.02308-22

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Microbiology

Virology

Abstract

SARS-CoV-2 infection primarily targets the lung but may also damage other organs, including the brain, heart, kidney, and intestine. Central nervous system (CNS) pathologies include loss of smell and taste, headache, delirium, acute psychosis, seizures, and stroke.

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