,  том 57 ,  издание 8 ,  страницы 4039-4041

MBX-500 Is Effective for Treatment of Clostridium difficile Infection in Gnotobiotic Piglets

Тип публикации: Journal Article
Дата публикации: 2013-08-09
SCImago Q1
Tоп 10% SCImago
WOS Q2
БС1
SJR: 1.473
CiteScore: 8
Impact factor: 4.2
ISSN: 00664804, 10986596
Pharmacology
Infectious Diseases
Pharmacology (medical)
Краткое описание
ABSTRACT

The novel antibiotic MBX-500, dosed at 100, 200, or 400 mg/kg twice daily for 7 days, was evaluated for the treatment of Clostridium difficile infection (CDI) in the gnotobiotic pig model. MBX-500 increased survival at all doses and at high doses improved clinical signs and reduced lesion severity, similar to vancomycin. Our results show that MBX-500 is an effective antibiotic for the treatment of diarrhea associated with CDI and prevents severe systemic disease.

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Future Medicinal Chemistry
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Russian Chemical Reviews
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ГОСТ |
Цитировать
Steele J. et al. MBX-500 Is Effective for Treatment of Clostridium difficile Infection in Gnotobiotic Piglets // Antimicrobial Agents and Chemotherapy. 2013. Vol. 57. No. 8. pp. 4039-4041.
ГОСТ со всеми авторами (до 50) Скопировать
Steele J., Zhang Q., Beamer G., Butler M., Bowlin T., Tzipori S. MBX-500 Is Effective for Treatment of Clostridium difficile Infection in Gnotobiotic Piglets // Antimicrobial Agents and Chemotherapy. 2013. Vol. 57. No. 8. pp. 4039-4041.
RIS |
Цитировать
TY - JOUR
DO - 10.1128/aac.00304-13
UR - https://doi.org/10.1128/aac.00304-13
TI - MBX-500 Is Effective for Treatment of Clostridium difficile Infection in Gnotobiotic Piglets
T2 - Antimicrobial Agents and Chemotherapy
AU - Steele, Jennifer
AU - Zhang, Quanshun
AU - Beamer, Gillian
AU - Butler, Michelle
AU - Bowlin, Terry
AU - Tzipori, Saul
PY - 2013
DA - 2013/08/09
PB - American Society for Microbiology
SP - 4039-4041
IS - 8
VL - 57
PMID - 23689716
SN - 0066-4804
SN - 1098-6596
ER -
BibTex |
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BibTex (до 50 авторов) Скопировать
@article{2013_Steele,
author = {Jennifer Steele and Quanshun Zhang and Gillian Beamer and Michelle Butler and Terry Bowlin and Saul Tzipori},
title = {MBX-500 Is Effective for Treatment of Clostridium difficile Infection in Gnotobiotic Piglets},
journal = {Antimicrobial Agents and Chemotherapy},
year = {2013},
volume = {57},
publisher = {American Society for Microbiology},
month = {aug},
url = {https://doi.org/10.1128/aac.00304-13},
number = {8},
pages = {4039--4041},
doi = {10.1128/aac.00304-13}
}
MLA
Цитировать
Steele, Jennifer, et al. “MBX-500 Is Effective for Treatment of Clostridium difficile Infection in Gnotobiotic Piglets.” Antimicrobial Agents and Chemotherapy, vol. 57, no. 8, Aug. 2013, pp. 4039-4041. https://doi.org/10.1128/aac.00304-13.
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