Open Access
Antimicrobial Agents and Chemotherapy, volume 58, issue 9, pages 5269-5279
Synergy of Streptogramin Antibiotics Occurs Independently of Their Effects on Translation
Noeske Jonas
1
,
Huang Jian
2
,
Olivier Nelson B
2
,
Giacobbe Robert A
3
,
Zambrowski Mark
3
,
Cate Jamie H. D.
1
1
Department of Molecular Cell Biology, California Institute of Quantitative Biosciences, University of California, Berkeley, California, USA
|
2
AstraZeneca R&D Boston, Discovery Sciences, Waltham, Massachusetts, USA
|
3
AstraZeneca R&D Boston, Infection Innovative Medicines Unit, Waltham, Massachusetts, USA
|
Publication type: Journal Article
Publication date: 2014-06-23
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 4.9
ISSN: 00664804, 10986596
PubMed ID:
24957822
Pharmacology
Infectious Diseases
Pharmacology (medical)
Abstract
ABSTRACT Streptogramin antibiotics are divided into types A and B, which in combination can act synergistically. We compared the molecular interactions of the streptogramin combinations Synercid (type A, dalfopristin; type B, quinupristin) and NXL 103 (type A, flopristin; type B, linopristin) with the Escherichia coli 70S ribosome by X-ray crystallography. We further analyzed the activity of the streptogramin components individually and in combination. The streptogramin A and B components in Synercid and NXL 103 exhibit synergistic antimicrobial activity against certain pathogenic bacteria. However, in transcription-coupled translation assays, only combinations that include dalfopristin, the streptogramin A component of Synercid, show synergy. Notably, the diethylaminoethylsulfonyl group in dalfopristin reduces its activity but is the basis for synergy in transcription-coupled translation assays before its rapid hydrolysis from the depsipeptide core. Replacement of the diethylaminoethylsulfonyl group in dalfopristin by a nonhydrolyzable group may therefore be beneficial for synergy. The absence of general streptogramin synergy in transcription-coupled translation assays suggests that the synergistic antimicrobial activity of streptogramins can occur independently of the effects of streptogramin on translation.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Noeske J. et al. Synergy of Streptogramin Antibiotics Occurs Independently of Their Effects on Translation // Antimicrobial Agents and Chemotherapy. 2014. Vol. 58. No. 9. pp. 5269-5279.
GOST all authors (up to 50)
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Noeske J., Huang J., Olivier N. B., Giacobbe R. A., Zambrowski M., Cate J. H. D. Synergy of Streptogramin Antibiotics Occurs Independently of Their Effects on Translation // Antimicrobial Agents and Chemotherapy. 2014. Vol. 58. No. 9. pp. 5269-5279.
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RIS
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TY - JOUR
DO - 10.1128/AAC.03389-14
UR - https://doi.org/10.1128%2FAAC.03389-14
TI - Synergy of Streptogramin Antibiotics Occurs Independently of Their Effects on Translation
T2 - Antimicrobial Agents and Chemotherapy
AU - Noeske, Jonas
AU - Huang, Jian
AU - Olivier, Nelson B
AU - Giacobbe, Robert A
AU - Zambrowski, Mark
AU - Cate, Jamie H. D.
PY - 2014
DA - 2014/06/23 00:00:00
PB - American Society for Microbiology
SP - 5269-5279
IS - 9
VL - 58
PMID - 24957822
SN - 0066-4804
SN - 1098-6596
ER -
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BibTex
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@article{2014_Noeske,
author = {Jonas Noeske and Jian Huang and Nelson B Olivier and Robert A Giacobbe and Mark Zambrowski and Jamie H. D. Cate},
title = {Synergy of Streptogramin Antibiotics Occurs Independently of Their Effects on Translation},
journal = {Antimicrobial Agents and Chemotherapy},
year = {2014},
volume = {58},
publisher = {American Society for Microbiology},
month = {jun},
url = {https://doi.org/10.1128%2FAAC.03389-14},
number = {9},
pages = {5269--5279},
doi = {10.1128/AAC.03389-14}
}
Cite this
MLA
Copy
Noeske, Jonas, et al. “Synergy of Streptogramin Antibiotics Occurs Independently of Their Effects on Translation.” Antimicrobial Agents and Chemotherapy, vol. 58, no. 9, Jun. 2014, pp. 5269-5279. https://doi.org/10.1128%2FAAC.03389-14.