Open Access
Clinical Microbiology Reviews, volume 24, issue 1, pages 71-109
Challenges of Antibacterial Discovery
1
LL Silver Consulting, LLC, 955 S. Springfield Ave., Unit C403, Springfield, New Jersey 07081
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Publication type: Journal Article
Publication date: 2011-01-06
Journal:
Clinical Microbiology Reviews
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 36.8
ISSN: 08938512, 10986618
PubMed ID:
21233508
Microbiology (medical)
Infectious Diseases
General Immunology and Microbiology
Public Health, Environmental and Occupational Health
Epidemiology
Abstract
SUMMARY The discovery of novel small-molecule antibacterial drugs has been stalled for many years. The purpose of this review is to underscore and illustrate those scientific problems unique to the discovery and optimization of novel antibacterial agents that have adversely affected the output of the effort. The major challenges fall into two areas: (i) proper target selection, particularly the necessity of pursuing molecular targets that are not prone to rapid resistance development, and (ii) improvement of chemical libraries to overcome limitations of diversity, especially that which is necessary to overcome barriers to bacterial entry and proclivity to be effluxed, especially in Gram-negative organisms. Failure to address these problems has led to a great deal of misdirected effort.
Citations by journals
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Journal of Medicinal Chemistry
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Journal of Medicinal Chemistry
31 publications, 3.2%
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ACS Infectious Diseases
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ACS Infectious Diseases
28 publications, 2.89%
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Antibiotics
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25 publications, 2.58%
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Antimicrobial Agents and Chemotherapy
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25 publications, 2.58%
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Scientific Reports
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Scientific Reports
24 publications, 2.47%
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PLoS ONE
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PLoS ONE
19 publications, 1.96%
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Bioorganic and Medicinal Chemistry Letters
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Bioorganic and Medicinal Chemistry Letters
19 publications, 1.96%
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European Journal of Medicinal Chemistry
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European Journal of Medicinal Chemistry
17 publications, 1.75%
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Bioorganic and Medicinal Chemistry
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Bioorganic and Medicinal Chemistry
17 publications, 1.75%
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Molecules
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Molecules
15 publications, 1.55%
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Frontiers in Microbiology
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Frontiers in Microbiology
14 publications, 1.44%
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ACS Chemical Biology
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ACS Chemical Biology
12 publications, 1.24%
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Journal of Antimicrobial Chemotherapy
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Journal of Antimicrobial Chemotherapy
12 publications, 1.24%
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Bioorganic Chemistry
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Bioorganic Chemistry
11 publications, 1.13%
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Future Medicinal Chemistry
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Future Medicinal Chemistry
9 publications, 0.93%
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mBio
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mBio
9 publications, 0.93%
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Journal of Antibiotics
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Journal of Antibiotics
8 publications, 0.82%
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Expert Opinion on Drug Discovery
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Expert Opinion on Drug Discovery
8 publications, 0.82%
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Nature Communications
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Nature Communications
7 publications, 0.72%
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ACS Medicinal Chemistry Letters
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ACS Medicinal Chemistry Letters
7 publications, 0.72%
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Organic and Biomolecular Chemistry
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Organic and Biomolecular Chemistry
7 publications, 0.72%
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Science Translational Medicine
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Science Translational Medicine
7 publications, 0.72%
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Proceedings of the National Academy of Sciences of the United States of America
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Proceedings of the National Academy of Sciences of the United States of America
7 publications, 0.72%
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Marine Drugs
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Marine Drugs
6 publications, 0.62%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
6 publications, 0.62%
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Pharmaceuticals
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Pharmaceuticals
6 publications, 0.62%
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Nature
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Nature
6 publications, 0.62%
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Journal of Chemical Information and Modeling
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Journal of Chemical Information and Modeling
5 publications, 0.52%
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Microorganisms
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Microorganisms
5 publications, 0.52%
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35
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Citations by publishers
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Elsevier
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Elsevier
186 publications, 19.18%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
121 publications, 12.47%
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Springer Nature
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Springer Nature
96 publications, 9.9%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
78 publications, 8.04%
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Wiley
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Wiley
67 publications, 6.91%
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American Society for Microbiology
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American Society for Microbiology
51 publications, 5.26%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
37 publications, 3.81%
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Taylor & Francis
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Taylor & Francis
35 publications, 3.61%
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Frontiers Media S.A.
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Frontiers Media S.A.
27 publications, 2.78%
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Oxford University Press
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Oxford University Press
25 publications, 2.58%
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Public Library of Science (PLoS)
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Public Library of Science (PLoS)
24 publications, 2.47%
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Future Medicine
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Future Medicine
12 publications, 1.24%
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American Association for the Advancement of Science (AAAS)
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American Association for the Advancement of Science (AAAS)
10 publications, 1.03%
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Bentham Science
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Bentham Science
9 publications, 0.93%
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SAGE
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SAGE
8 publications, 0.82%
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Proceedings of the National Academy of Sciences (PNAS)
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Proceedings of the National Academy of Sciences (PNAS)
7 publications, 0.72%
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American Society for Biochemistry and Molecular Biology
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American Society for Biochemistry and Molecular Biology
5 publications, 0.52%
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Mary Ann Liebert
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Mary Ann Liebert
4 publications, 0.41%
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Thieme
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Thieme
4 publications, 0.41%
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Microbiology Society
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Microbiology Society
3 publications, 0.31%
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King Saud University
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King Saud University
3 publications, 0.31%
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IOP Publishing
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IOP Publishing
3 publications, 0.31%
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Wolters Kluwer Health
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Wolters Kluwer Health
2 publications, 0.21%
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Future Science
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Future Science, 2, 0.21%
Future Science
2 publications, 0.21%
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Cambridge University Press
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Cambridge University Press
2 publications, 0.21%
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BMJ
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BMJ
2 publications, 0.21%
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Annual Reviews
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Annual Reviews
2 publications, 0.21%
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Cold Spring Harbor Laboratory
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Cold Spring Harbor Laboratory
2 publications, 0.21%
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Han-Gug Misaengmul Hag-hoe/The Microbiological Society of Korea
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Han-Gug Misaengmul Hag-hoe/The Microbiological Society of Korea, 1, 0.1%
Han-Gug Misaengmul Hag-hoe/The Microbiological Society of Korea
1 publication, 0.1%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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RIS
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TY - JOUR
DO - 10.1128/CMR.00030-10
UR - https://doi.org/10.1128%2FCMR.00030-10
TI - Challenges of Antibacterial Discovery
T2 - Clinical Microbiology Reviews
AU - Silver, Lynn L
PY - 2011
DA - 2011/01/06 00:00:00
PB - American Society for Microbiology
SP - 71-109
IS - 1
VL - 24
PMID - 21233508
SN - 0893-8512
SN - 1098-6618
ER -
Cite this
BibTex
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@article{2011_Silver,
author = {Lynn L Silver},
title = {Challenges of Antibacterial Discovery},
journal = {Clinical Microbiology Reviews},
year = {2011},
volume = {24},
publisher = {American Society for Microbiology},
month = {jan},
url = {https://doi.org/10.1128%2FCMR.00030-10},
number = {1},
pages = {71--109},
doi = {10.1128/CMR.00030-10}
}
Cite this
MLA
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Silver, Lynn L.. “Challenges of Antibacterial Discovery.” Clinical Microbiology Reviews, vol. 24, no. 1, Jan. 2011, pp. 71-109. https://doi.org/10.1128%2FCMR.00030-10.