Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Processing by the Endoprotease SKI-1/S1P Is Critical for Virus Infectivity
Publication type: Journal Article
Publication date: 2007-12-09
scimago Q1
wos Q2
SJR: 1.283
CiteScore: 7.8
Impact factor: 3.8
ISSN: 0022538X, 10985514
PubMed ID:
17898072
Microbiology
Immunology
Insect Science
Virology
Abstract
ABSTRACT
Crimean-Congo hemorrhagic fever virus (CCHFV) causes severe human disease. The CCHFV medium RNA encodes a polyprotein which is proteolytically processed to yield the glycoprotein precursors PreGn and PreGc, followed by structural glycoproteins Gn and Gc. Subtilisin kexin isozyme-1/site-1 protease (SKI-1/S1P) plays a central role in Gn processing. Here we show that CCHFV-infected cells deficient in SKI-1/S1P produce no infectious virus, although PreGn and PreGc accumulated normally in the Golgi apparatus, the site of virus assembly. Only nucleoprotein-containing particles which lacked virus glycoproteins (Gn/Gc or PreGn/PreGc) were secreted. Complementation of SKI-1/S1P-deficient cells with a SKI-1/S1P expression vector restored release of infectious virus (>10 6 PFU/ml), confirming that SKI-1/S1P processing is required for incorporation of viral glycoproteins. SKI-1/S1P may represent a promising antiviral target.
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Total citations:
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Citations from 2024:
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(20.93%)
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Bergeron É., Vincent M. J., Nichol S. T. Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Processing by the Endoprotease SKI-1/S1P Is Critical for Virus Infectivity // Journal of Virology. 2007. Vol. 81. No. 23. pp. 13271-13276.
GOST all authors (up to 50)
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Bergeron É., Vincent M. J., Nichol S. T. Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Processing by the Endoprotease SKI-1/S1P Is Critical for Virus Infectivity // Journal of Virology. 2007. Vol. 81. No. 23. pp. 13271-13276.
Cite this
RIS
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TY - JOUR
DO - 10.1128/jvi.01647-07
UR - https://doi.org/10.1128/jvi.01647-07
TI - Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Processing by the Endoprotease SKI-1/S1P Is Critical for Virus Infectivity
T2 - Journal of Virology
AU - Bergeron, Éric
AU - Vincent, Martin J.
AU - Nichol, Stuart T.
PY - 2007
DA - 2007/12/09
PB - American Society for Microbiology
SP - 13271-13276
IS - 23
VL - 81
PMID - 17898072
SN - 0022-538X
SN - 1098-5514
ER -
Cite this
BibTex (up to 50 authors)
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@article{2007_Bergeron,
author = {Éric Bergeron and Martin J. Vincent and Stuart T. Nichol},
title = {Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Processing by the Endoprotease SKI-1/S1P Is Critical for Virus Infectivity},
journal = {Journal of Virology},
year = {2007},
volume = {81},
publisher = {American Society for Microbiology},
month = {dec},
url = {https://doi.org/10.1128/jvi.01647-07},
number = {23},
pages = {13271--13276},
doi = {10.1128/jvi.01647-07}
}
Cite this
MLA
Copy
Bergeron, Éric, et al. “Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Processing by the Endoprotease SKI-1/S1P Is Critical for Virus Infectivity.” Journal of Virology, vol. 81, no. 23, Dec. 2007, pp. 13271-13276. https://doi.org/10.1128/jvi.01647-07.