Differential Inhibition of TRAIL-Mediated DR5-DISC Formation by Decoy Receptors 1 and 2
Тип публикации: Journal Article
Дата публикации: 2006-10-01
scimago Q2
wos Q3
БС1
SJR: 0.988
CiteScore: 5.9
Impact factor: 2.7
ISSN: 02707306, 10985549
PubMed ID:
16980609
Molecular Biology
Cell Biology
Краткое описание
ABSTRACT Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family that induces cancer cell death by apoptosis with some selectivity. TRAIL-induced apoptosis is mediated by the transmembrane receptors death receptor 4 (DR4) (also known as TRAIL-R1) and DR5 (TRAIL-R2). TRAIL can also bind decoy receptor 1 (DcR1) (TRAIL-R3) and DcR2 (TRAIL-R4) that fail to induce apoptosis since they lack and have a truncated cytoplasmic death domain, respectively. In addition, DcR1 and DcR2 inhibit DR4- and DR5-mediated, TRAIL-induced apoptosis and we demonstrate here that this occurs through distinct mechanisms. While DcR1 prevents the assembly of the death-inducing signaling complex (DISC) by titrating TRAIL within lipid rafts, DcR2 is corecruited with DR5 within the DISC, where it inhibits initiator caspase activation. In addition, DcR2 prevents DR4 recruitment within the DR5 DISC. The specificity of DcR1- and DcR2-mediated TRAIL inhibition reveals an additional level of complexity for the regulation of TRAIL signaling.
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ГОСТ
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Merino D. et al. Differential Inhibition of TRAIL-Mediated DR5-DISC Formation by Decoy Receptors 1 and 2 // Molecular and Cellular Biology. 2006. Vol. 26. No. 19. pp. 7046-7055.
ГОСТ со всеми авторами (до 50)
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Merino D., Lalaoui N., Morizot A., Schneider P., Solary E., Micheau O. Differential Inhibition of TRAIL-Mediated DR5-DISC Formation by Decoy Receptors 1 and 2 // Molecular and Cellular Biology. 2006. Vol. 26. No. 19. pp. 7046-7055.
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TY - JOUR
DO - 10.1128/MCB.00520-06
UR - https://doi.org/10.1128/MCB.00520-06
TI - Differential Inhibition of TRAIL-Mediated DR5-DISC Formation by Decoy Receptors 1 and 2
T2 - Molecular and Cellular Biology
AU - Merino, Delphine
AU - Lalaoui, Najoua
AU - Morizot, Alexandre
AU - Schneider, Pascal
AU - Solary, E
AU - Micheau, Olivier
PY - 2006
DA - 2006/10/01
PB - American Society for Microbiology
SP - 7046-7055
IS - 19
VL - 26
PMID - 16980609
SN - 0270-7306
SN - 1098-5549
ER -
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BibTex (до 50 авторов)
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@article{2006_Merino,
author = {Delphine Merino and Najoua Lalaoui and Alexandre Morizot and Pascal Schneider and E Solary and Olivier Micheau},
title = {Differential Inhibition of TRAIL-Mediated DR5-DISC Formation by Decoy Receptors 1 and 2},
journal = {Molecular and Cellular Biology},
year = {2006},
volume = {26},
publisher = {American Society for Microbiology},
month = {oct},
url = {https://doi.org/10.1128/MCB.00520-06},
number = {19},
pages = {7046--7055},
doi = {10.1128/MCB.00520-06}
}
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MLA
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Merino, Delphine, et al. “Differential Inhibition of TRAIL-Mediated DR5-DISC Formation by Decoy Receptors 1 and 2.” Molecular and Cellular Biology, vol. 26, no. 19, Oct. 2006, pp. 7046-7055. https://doi.org/10.1128/MCB.00520-06.