Biology Bulletin, volume 37, issue 6, pages 612-618
The effect of volatile antioxidants of plant origin on leukemogenesis in mice
E. B. Burlakova
1
,
V N Erokhin
1
,
T. A. Misharina
1
,
L. D. Fatkullina
1
,
A V Krementsova
1
,
Vitaly Semenov
1
,
M. B. Terenina
1
,
A K Vorobyova
1
,
A N Goloshchapov
1
Publication type: Journal Article
Publication date: 2010-12-01
Journal:
Biology Bulletin
scimago Q3
wos Q4
SJR: 0.190
CiteScore: 0.7
Impact factor: 0.5
ISSN: 10623590, 16083059
General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences
Abstract
The effect of savory essential oil added with drinking water (150 ng/ml) or with feed (2.5 μg/g) on the lifetime of AKR mice and the parameters of oxidative stress in animal blood were investigated. It was found for the first time that long-term administration of an essential oil in low doses increased the average lifetime of mice by 20–35% and was accompanied by a decrease in the hemolysis level and the content of lipid peroxidation products in erythrocytes of mice, as well as alteration in the structural state of their membranes and stabilization of polyunsaturated fatty acids level in mice liver cells.
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