Russian Journal of Bioorganic Chemistry, volume 47, issue 4, pages 828-836
Preparing Modified Hyaluronic Acid with Tunable Content of Vinyl Groups for Use in Fabrication of Scaffolds by Photoinduced Crosslinking
Sochilina A V
1, 2
,
Savelyev A G
2, 3
,
Akasov R A
1, 2, 3
,
Zubov V.P
1
,
Khaydukov E V
1, 2, 3
,
Generalova A N
1
Publication type: Journal Article
Publication date: 2021-07-01
Quartile SCImago
Q4
Quartile WOS
Q4
Impact factor: 1
ISSN: 10681620, 1608330X
Organic Chemistry
Biochemistry
Abstract
Materials based on hyaluronic acid (HA) are extensively used in tissue engineering as scaffolds. Photoinduced crosslinking is one way to prepare them, and, for this, HA must be modified with vinyl groups, which are capable of participating in free-radical reactions upon exposure to light. The quantity of grafted vinyl groups, represented as the degree of substitution (DS), is an important parameter of modified HA (mHA) that is related to the mechanical, chemical, and biological properties of scaffolds. Here, we demonstrate the feasibility of tuning DS by varying the reaction parameters (composition and concentration of reaction components and reaction conditions) and investigate the effect of DS on the viscosity of mHA solutions. As example, we consider the photoinduced reaction of mHA in the presence of flavin mononucleotide as the initiator, which can be used in fabrication of noncytotoxic scaffolds by 3D printing. The growth behavior of fibroblasts on the scaffold surface is studied.
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Sochilina A. V. et al. Preparing Modified Hyaluronic Acid with Tunable Content of Vinyl Groups for Use in Fabrication of Scaffolds by Photoinduced Crosslinking // Russian Journal of Bioorganic Chemistry. 2021. Vol. 47. No. 4. pp. 828-836.
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Sochilina A. V., Savelyev A. G., Akasov R. A., Zubov V., Khaydukov E. V., Generalova A. N. Preparing Modified Hyaluronic Acid with Tunable Content of Vinyl Groups for Use in Fabrication of Scaffolds by Photoinduced Crosslinking // Russian Journal of Bioorganic Chemistry. 2021. Vol. 47. No. 4. pp. 828-836.
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TY - JOUR
DO - 10.1134/S1068162021040191
UR - https://doi.org/10.1134%2FS1068162021040191
TI - Preparing Modified Hyaluronic Acid with Tunable Content of Vinyl Groups for Use in Fabrication of Scaffolds by Photoinduced Crosslinking
T2 - Russian Journal of Bioorganic Chemistry
AU - Sochilina, A V
AU - Savelyev, A G
AU - Akasov, R A
AU - Zubov, V.P
AU - Khaydukov, E V
AU - Generalova, A N
PY - 2021
DA - 2021/07/01 00:00:00
PB - Pleiades Publishing
SP - 828-836
IS - 4
VL - 47
SN - 1068-1620
SN - 1608-330X
ER -
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@article{2021_Sochilina,
author = {A V Sochilina and A G Savelyev and R A Akasov and V.P Zubov and E V Khaydukov and A N Generalova},
title = {Preparing Modified Hyaluronic Acid with Tunable Content of Vinyl Groups for Use in Fabrication of Scaffolds by Photoinduced Crosslinking},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2021},
volume = {47},
publisher = {Pleiades Publishing},
month = {jul},
url = {https://doi.org/10.1134%2FS1068162021040191},
number = {4},
pages = {828--836},
doi = {10.1134/S1068162021040191}
}
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Sochilina, A. V., et al. “Preparing Modified Hyaluronic Acid with Tunable Content of Vinyl Groups for Use in Fabrication of Scaffolds by Photoinduced Crosslinking.” Russian Journal of Bioorganic Chemistry, vol. 47, no. 4, Jul. 2021, pp. 828-836. https://doi.org/10.1134%2FS1068162021040191.
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