Synthesis and Analgesic Activity of N,6-Diaryl-4-hydroxy-4-methyl-2-oxocyclohexane-1-carboxamides and Their Dehydration Products
Publication type: Journal Article
Publication date: 2020-09-01
scimago Q4
wos Q4
SJR: 0.179
CiteScore: 1.4
Impact factor: 0.8
ISSN: 10703632, 16083350
General Chemistry
Abstract
A series of new N,6-diaryl-4-hydroxy-4-methyl-2-oxocyclohexane-1-carboxamides was obtained through the reaction of N-arylamides of acetoacetic acid with benzalacetone and 4-chlorobenzalacetone under basic conditions (KOH) in methanol at room temperature. Increasing of the amount of potassium hydroxide used in the reaction led to the formation of dehydration products, namely N,6-diaryl-4-methyl-2-oxocyclohex-3-ene-1-carboxamides. The latter were also formed by using unsubstituted acetoacetamide and N-methylacetoacetamide. The synthesized compounds were tested for analgesic activity.
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Nosova N. V. et al. Synthesis and Analgesic Activity of N,6-Diaryl-4-hydroxy-4-methyl-2-oxocyclohexane-1-carboxamides and Their Dehydration Products // Russian Journal of General Chemistry. 2020. Vol. 90. No. 9. pp. 1581-1590.
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Nosova N. V., Sokolov A. A., Gein O. N., Gein V. L., Yankin A. N., Danilov S. E., Dmitriev M. V. Synthesis and Analgesic Activity of N,6-Diaryl-4-hydroxy-4-methyl-2-oxocyclohexane-1-carboxamides and Their Dehydration Products // Russian Journal of General Chemistry. 2020. Vol. 90. No. 9. pp. 1581-1590.
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TY - JOUR
DO - 10.1134/S1070363220090017
UR - https://doi.org/10.1134/S1070363220090017
TI - Synthesis and Analgesic Activity of N,6-Diaryl-4-hydroxy-4-methyl-2-oxocyclohexane-1-carboxamides and Their Dehydration Products
T2 - Russian Journal of General Chemistry
AU - Nosova, N V
AU - Sokolov, A. A.
AU - Gein, O N
AU - Gein, V L
AU - Yankin, A N
AU - Danilov, S E
AU - Dmitriev, M V
PY - 2020
DA - 2020/09/01
PB - Pleiades Publishing
SP - 1581-1590
IS - 9
VL - 90
SN - 1070-3632
SN - 1608-3350
ER -
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@article{2020_Nosova,
author = {N V Nosova and A. A. Sokolov and O N Gein and V L Gein and A N Yankin and S E Danilov and M V Dmitriev},
title = {Synthesis and Analgesic Activity of N,6-Diaryl-4-hydroxy-4-methyl-2-oxocyclohexane-1-carboxamides and Their Dehydration Products},
journal = {Russian Journal of General Chemistry},
year = {2020},
volume = {90},
publisher = {Pleiades Publishing},
month = {sep},
url = {https://doi.org/10.1134/S1070363220090017},
number = {9},
pages = {1581--1590},
doi = {10.1134/S1070363220090017}
}
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MLA
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Nosova, N. V., et al. “Synthesis and Analgesic Activity of N,6-Diaryl-4-hydroxy-4-methyl-2-oxocyclohexane-1-carboxamides and Their Dehydration Products.” Russian Journal of General Chemistry, vol. 90, no. 9, Sep. 2020, pp. 1581-1590. https://doi.org/10.1134/S1070363220090017.
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