Russian Journal of Genetics, volume 60, issue 11, pages 1548-1555
Expression of miR-29a, miR-30c, and miR-150 microRNAs in the Long-Term Period after Chronic Radiation Exposure
M A Yanishevskaya
1
,
E.A. Blinova
1, 2
,
A V Akleyev
1, 2
1
Urals Research Center for Radiation Medicine, Federal Medical-Biological Agency of the Russian Federation, Chelyabinsk, Russia
Publication type: Journal Article
Publication date: 2024-11-25
Journal:
Russian Journal of Genetics
scimago Q4
wos Q4
SJR: 0.185
CiteScore: 1.0
Impact factor: 0.6
ISSN: 10227954, 16083369
Abstract
Every year, more and more data demonstrate that microRNA expression levels can be changed significantly after acute radiation exposure, and microRNAs themselves play an important role in the cellular response to ionizing radiation. However, regulation of microRNA expression after chronic radiation exposure within the low and middle dose range is poorly studied. In the present study, the expression of mature miR-29a, miR-30c, and miR-150 microRNAs in whole blood from 81 individuals in the long-term period after chronic low dose-rate radiation exposure was analyzed by real-time PCR method. The mean age of the studied people was 72 years, and the accumulated radiation doses in red bone marrow (RBM), thymus, and peripheral lymphoid organs ranged from 2.13 to 1867.55 mGy and from 0.18 to 488.79 mGy, respectively. More than 70 years after the onset of radiation exposure, a statistically significant dose-dependent decrease in miR-30c microRNA expression was found in exposed individuals in RBM, thymus, and peripheral lymphoid organs.
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