Russian Journal of Genetics, volume 60, issue 11, pages 1584-1587

Genome Analysis of Fur Color in Sable (Martes zibellina L.), the Search for Mutations Determining the Absence of Pigmentation (Albino)

P A Filimonov 1
A D Manakhov 1, 2, 3
M. Y. Mitina 2
A A Onokhov 1
I E Chernova 4
L V Maksimova 4
S N Kashtanov 1
E I Rogaev 2, 3, 5
2
 
Center for Genetics and Life Science, Sirius University of Science and Technology, Sirius, Sochi, Russia
4
 
AO “Russian Sable” Moscow oblast, Zverosovkhoz, Russia
5
 
Department of Psychiatry, University of Massachusetts Chan Medical School, Worcester, USA
Publication typeJournal Article
Publication date2024-11-25
scimago Q4
wos Q4
SJR0.185
CiteScore1.0
Impact factor0.6
ISSN10227954, 16083369
Abstract
In domesticated sable population, after almost 100 years of selective breeding, individuals with colored fur began to be recorded. In particular, in the offspring of a pair of sables with black coat color, a puppy with pastel coat color was identified. In the TYRP1 gene that determines this sable coat color, single nucleotide insertion was determined, and the trait inheritance mode was recessive. In 2022, in this population, puppies with white coat color were born simultaneously to the representatives of two sable lines. In most mammalian species, albinism is caused by the mutations in the TYR gene, which encodes the tyrosinase enzyme. In the present study, the sable TYR gene was analyzed as a functional candidate gene for albinism. Sequence analysis of the TYR gene coding region and splicing sites did not reveal any differences of white sables from standard colored sables, which suggested that the studied phenotype was caused by genetic variants in other genes.

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