Pleiades Publishing
Russian Journal of Bioorganic Chemistry
,  volume 37 ,  issue 2 ,  pages 131-145

Mass spectrometric determination of the quantity and enzyme activity of cytochromes P450

Publication type: Journal Article
Publication date: 2011-03-01
Pleiades Publishing
scimago Q4
wos Q3
SJR: 0.267
CiteScore: 1.9
Impact factor: 1.7
ISSN: 10681620, 1608330X, 15739163
Organic Chemistry
Biochemistry
Abstract
Concentrations of selected members of cytochrome P450 1A, 3A, 1E, 2C, and 2D subfamilies were measured on a triple quadrupole mass spectrometer using the method of multiple reaction monitoring (MRM). The procedure was developed and tested on samples of mouse liver microsomes from control and phenobarbital or methylcholanthrene-induced groups. The procedure enabled the mass spectrometric quantitation of individual P450 isoforms without using isotopic labels or chemical derivatization. Quantitation results for certain P450 isoforms correlated with the changes in enzyme activity measured using isoform-specific marker substrates.
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Moskaleva N. E., Zgoda V. G., Archakov A. I. Mass spectrometric determination of the quantity and enzyme activity of cytochromes P450 // Russian Journal of Bioorganic Chemistry. 2011. Vol. 37. No. 2. pp. 131-145.
GOST all authors (up to 50) Copy
Moskaleva N. E., Zgoda V. G., Archakov A. I. Mass spectrometric determination of the quantity and enzyme activity of cytochromes P450 // Russian Journal of Bioorganic Chemistry. 2011. Vol. 37. No. 2. pp. 131-145.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1134/s1068162011010122
UR - https://doi.org/10.1134/s1068162011010122
TI - Mass spectrometric determination of the quantity and enzyme activity of cytochromes P450
T2 - Russian Journal of Bioorganic Chemistry
AU - Moskaleva, N E
AU - Zgoda, V G
AU - Archakov, A. I.
PY - 2011
DA - 2011/03/01
PB - Pleiades Publishing
SP - 131-145
IS - 2
VL - 37
PMID - 21721249
SN - 1068-1620
SN - 1608-330X
SN - 1573-9163
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2011_Moskaleva,
author = {N E Moskaleva and V G Zgoda and A. I. Archakov},
title = {Mass spectrometric determination of the quantity and enzyme activity of cytochromes P450},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2011},
volume = {37},
publisher = {Pleiades Publishing},
month = {mar},
url = {https://doi.org/10.1134/s1068162011010122},
number = {2},
pages = {131--145},
doi = {10.1134/s1068162011010122}
}
MLA
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MLA Copy
Moskaleva, N. E., et al. “Mass spectrometric determination of the quantity and enzyme activity of cytochromes P450.” Russian Journal of Bioorganic Chemistry, vol. 37, no. 2, Mar. 2011, pp. 131-145. https://doi.org/10.1134/s1068162011010122.