том 48 издание 3 страницы 628-635

New Hybrid Molecules Based on Sulfur-Containing Nicotinonitriles: Synthesis, Analgesic Activity in Acetic Acid-Induced Writhing Test, and Molecular Docking Studies

Тип публикацииJournal Article
Дата публикации2022-06-21
scimago Q4
wos Q3
БС2
SJR0.267
CiteScore1.9
Impact factor1.7
ISSN10681620, 1608330X, 15739163
Organic Chemistry
Biochemistry
Краткое описание
New hybrid molecules bearing furyl and 1,4-dihydronicotinonitrile (or 1,4,5,6-tetrahydronicotinonitrile) fragments have been prepared. The analgesic activity was studied in vivo (rats) in acetic acid-induced writhing test. Some compounds showed activity exceeding that of the reference compound (metamizole). Molecular docking was performed with all the compounds against COX-1 and COX-2. Also, we performed the docking studies in order to find new possible protein targets.
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Molecules
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Russian Journal of General Chemistry
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Russian Journal of Bioorganic Chemistry
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Биоорганическая химия
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Russian Chemical Reviews
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ACS Medicinal Chemistry Letters
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ГОСТ |
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Krivokolysko D. S. et al. New Hybrid Molecules Based on Sulfur-Containing Nicotinonitriles: Synthesis, Analgesic Activity in Acetic Acid-Induced Writhing Test, and Molecular Docking Studies // Russian Journal of Bioorganic Chemistry. 2022. Vol. 48. No. 3. pp. 628-635.
ГОСТ со всеми авторами (до 50) Скопировать
Krivokolysko D. S., Dotsenko V. V., Bibik E. Yu., Samokish A. A., Venidiktova Y. S., Frolov K. A., Krivokolysko S. G., PANKOV A. A., Aksenov N. A., Aksenova I. V. New Hybrid Molecules Based on Sulfur-Containing Nicotinonitriles: Synthesis, Analgesic Activity in Acetic Acid-Induced Writhing Test, and Molecular Docking Studies // Russian Journal of Bioorganic Chemistry. 2022. Vol. 48. No. 3. pp. 628-635.
RIS |
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TY - JOUR
DO - 10.1134/s1068162022030104
UR - https://doi.org/10.1134/s1068162022030104
TI - New Hybrid Molecules Based on Sulfur-Containing Nicotinonitriles: Synthesis, Analgesic Activity in Acetic Acid-Induced Writhing Test, and Molecular Docking Studies
T2 - Russian Journal of Bioorganic Chemistry
AU - Krivokolysko, D S
AU - Dotsenko, V V
AU - Bibik, E Yu
AU - Samokish, A A
AU - Venidiktova, Y S
AU - Frolov, K A
AU - Krivokolysko, S G
AU - PANKOV, A. A.
AU - Aksenov, N A
AU - Aksenova, I V
PY - 2022
DA - 2022/06/21
PB - Pleiades Publishing
SP - 628-635
IS - 3
VL - 48
SN - 1068-1620
SN - 1608-330X
SN - 1573-9163
ER -
BibTex |
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BibTex (до 50 авторов) Скопировать
@article{2022_Krivokolysko,
author = {D S Krivokolysko and V V Dotsenko and E Yu Bibik and A A Samokish and Y S Venidiktova and K A Frolov and S G Krivokolysko and A. A. PANKOV and N A Aksenov and I V Aksenova},
title = {New Hybrid Molecules Based on Sulfur-Containing Nicotinonitriles: Synthesis, Analgesic Activity in Acetic Acid-Induced Writhing Test, and Molecular Docking Studies},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2022},
volume = {48},
publisher = {Pleiades Publishing},
month = {jun},
url = {https://doi.org/10.1134/s1068162022030104},
number = {3},
pages = {628--635},
doi = {10.1134/s1068162022030104}
}
MLA
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Krivokolysko, D. S., et al. “New Hybrid Molecules Based on Sulfur-Containing Nicotinonitriles: Synthesis, Analgesic Activity in Acetic Acid-Induced Writhing Test, and Molecular Docking Studies.” Russian Journal of Bioorganic Chemistry, vol. 48, no. 3, Jun. 2022, pp. 628-635. https://doi.org/10.1134/s1068162022030104.