Schiff Bases of Indole-3-Carbaldehyde: Synthesis and Evaluation as Antimicrobial Agents
Publication type: Journal Article
Publication date: 2022-10-29
scimago Q4
wos Q3
SJR: 0.267
CiteScore: 1.9
Impact factor: 1.7
ISSN: 10681620, 1608330X, 15739163
Organic Chemistry
Biochemistry
Abstract
A series of Schiff bases of indole-3-carbaldehyde were synthesized by the condensation reaction of indole-3-carbaldehyde with different aryl amines. The reaction of indole-3-carbaldehyde with different aryl amines was carried out in the presence of glacial acetic acid. All the synthesized compounds were characterized with microanalytical data 1H and 13C NMR, FT-IR spectroscopy and Mass spectrometry and screened for their in vitro microbial activity against bacterial strain Dickeya species as well as fungal culture Fusarium oxysporum using agar well diffusion method. The standard used for bacterial and fungal cultures were Carbendazim and Gentamicin, respectively. The results revealed that the synthesized Schiff base N‑((indol-1H-3-yl)methylene)-4-nitrobenzenamine exhibited the maximum activity against both bacteria (MIC = 2000 µg/mL) as well as fungus (MFC = 5000 µg/mL) cultures as compared with all other synthesized compounds.
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7
Total citations:
7
Citations from 2025:
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(71.43%)
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GOST
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Priya B., Utreja D., Kalia A. Schiff Bases of Indole-3-Carbaldehyde: Synthesis and Evaluation as Antimicrobial Agents // Russian Journal of Bioorganic Chemistry. 2022.
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Priya B., Utreja D., Kalia A. Schiff Bases of Indole-3-Carbaldehyde: Synthesis and Evaluation as Antimicrobial Agents // Russian Journal of Bioorganic Chemistry. 2022.
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RIS
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TY - JOUR
DO - 10.1134/s1068162022060188
UR - https://doi.org/10.1134/s1068162022060188
TI - Schiff Bases of Indole-3-Carbaldehyde: Synthesis and Evaluation as Antimicrobial Agents
T2 - Russian Journal of Bioorganic Chemistry
AU - Priya, B.
AU - Utreja, D
AU - Kalia, A.
PY - 2022
DA - 2022/10/29
PB - Pleiades Publishing
SN - 1068-1620
SN - 1608-330X
SN - 1573-9163
ER -
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@article{2022_Priya,
author = {B. Priya and D Utreja and A. Kalia},
title = {Schiff Bases of Indole-3-Carbaldehyde: Synthesis and Evaluation as Antimicrobial Agents},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2022},
publisher = {Pleiades Publishing},
month = {oct},
url = {https://doi.org/10.1134/s1068162022060188},
doi = {10.1134/s1068162022060188}
}