Schiff Bases of Indole-3-Carbaldehyde: Synthesis and Evaluation as Antimicrobial Agents

A series of Schiff bases of indole-3-carbaldehyde were synthesized by the condensation reaction of indole-3-carbaldehyde with different aryl amines. The reaction of indole-3-carbaldehyde with different aryl amines was carried out in the presence of glacial acetic acid. All the synthesized compounds were characterized with microanalytical data 1H and 13C NMR, FT-IR spectroscopy and Mass spectrometry and screened for their in vitro microbial activity against bacterial strain Dickeya species as well as fungal culture Fusarium oxysporum using agar well diffusion method. The standard used for bacterial and fungal cultures were Carbendazim and Gentamicin, respectively. The results revealed that the synthesized Schiff base N‑((indol-1H-3-yl)methylene)-4-nitrobenzenamine exhibited the maximum activity against both bacteria (MIC = 2000 µg/mL) as well as fungus (MFC = 5000 µg/mL) cultures as compared with all other synthesized compounds.