Efficient Synthesis of Deuterium-Labelled Ganciclovir-d5 and Its Prodrug Valganciclovir-d5
2
Faculty of Pharmaceutical Science, Assam Down Town University, Panikhaiti, Guwahati, Assam, India
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Publication type: Journal Article
Publication date: 2022-04-01
scimago Q4
wos Q4
SJR: 0.179
CiteScore: 1.4
Impact factor: 0.8
ISSN: 10703632, 16083350
General Chemistry
Abstract
An efficient protocol has been developed for the synthesis of deuterium labeled ganciclovir-d5, a potent anti-cytomegalovirus agent and its prodrug, valganciclovir-d5, by using inexpensive and commercially available glycerol-d5 reagent. Structure and purity of the synthesized compounds are confirmed by 1H NMR and MS spectral data. The deuterium incorporation in ganciclovir-d5 and its prodrug was >98% which resembles the reported earlier deuterium abundance in the labeled starting material (glycerol-d5, >98% atom D). The results indicate that there is no loss of deuterium by exchange in the course of synthesis. Hence, these molecules can be used as standards in bio-analytical studies.
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Parameshwar R., Durgaprasad K., Madheswaragupta P. Efficient Synthesis of Deuterium-Labelled Ganciclovir-d5 and Its Prodrug Valganciclovir-d5 // Russian Journal of General Chemistry. 2022. Vol. 92. No. 4. pp. 739-742.
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Parameshwar R., Durgaprasad K., Madheswaragupta P. Efficient Synthesis of Deuterium-Labelled Ganciclovir-d5 and Its Prodrug Valganciclovir-d5 // Russian Journal of General Chemistry. 2022. Vol. 92. No. 4. pp. 739-742.
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TY - JOUR
DO - 10.1134/s1070363222040168
UR - https://doi.org/10.1134/s1070363222040168
TI - Efficient Synthesis of Deuterium-Labelled Ganciclovir-d5 and Its Prodrug Valganciclovir-d5
T2 - Russian Journal of General Chemistry
AU - Parameshwar, R
AU - Durgaprasad, K
AU - Madheswaragupta, Prathap
PY - 2022
DA - 2022/04/01
PB - Pleiades Publishing
SP - 739-742
IS - 4
VL - 92
SN - 1070-3632
SN - 1608-3350
ER -
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BibTex (up to 50 authors)
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@article{2022_Parameshwar,
author = {R Parameshwar and K Durgaprasad and Prathap Madheswaragupta},
title = {Efficient Synthesis of Deuterium-Labelled Ganciclovir-d5 and Its Prodrug Valganciclovir-d5},
journal = {Russian Journal of General Chemistry},
year = {2022},
volume = {92},
publisher = {Pleiades Publishing},
month = {apr},
url = {https://doi.org/10.1134/s1070363222040168},
number = {4},
pages = {739--742},
doi = {10.1134/s1070363222040168}
}
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MLA
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Parameshwar, R., et al. “Efficient Synthesis of Deuterium-Labelled Ganciclovir-d5 and Its Prodrug Valganciclovir-d5.” Russian Journal of General Chemistry, vol. 92, no. 4, Apr. 2022, pp. 739-742. https://doi.org/10.1134/s1070363222040168.