Synthesis and Antinociceptive Activity of Substituted 2-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thiophene-2-ylamino)-4-oxobut-2-enoates
Тип публикации: Journal Article
Дата публикации: 2022-10-01
SCImago Q4
WOS Q4
БС2
SJR: 0.205
CiteScore: 1.4
Impact factor: 0.8
ISSN: 10703632, 16083350
General Chemistry
Краткое описание
A method was proposed for the synthesis of substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxobut-2-enoates containing a nitrile substituent in the thiophene ring by reacting the corresponding 3-thienylimino-3H-furan-2-ones with primary alcohols. The antinociceptive activity and acute toxicity of the obtained compounds were investigated. It was found that the substituted esters have pronounced antinociceptive activity and low toxicity. According to the classification of toxicity of drugs, the obtained substituted of 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxobut-2-enoates belong to the V class toxicity.
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Gorbunova I. A. et al. Synthesis and Antinociceptive Activity of Substituted 2-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thiophene-2-ylamino)-4-oxobut-2-enoates // Russian Journal of General Chemistry. 2022. Vol. 92. No. 10. pp. 1899-1905.
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Gorbunova I. A., Sharavyeva Yu. O., Makhmudov R. R., Shipilovskikh D. A., Shadrin V. M., Pulina N. A., Shipilovskikh S. A. Synthesis and Antinociceptive Activity of Substituted 2-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thiophene-2-ylamino)-4-oxobut-2-enoates // Russian Journal of General Chemistry. 2022. Vol. 92. No. 10. pp. 1899-1905.
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TY - JOUR
DO - 10.1134/s1070363222100048
UR - https://doi.org/10.1134/s1070363222100048
TI - Synthesis and Antinociceptive Activity of Substituted 2-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thiophene-2-ylamino)-4-oxobut-2-enoates
T2 - Russian Journal of General Chemistry
AU - Gorbunova, I A
AU - Sharavyeva, Yu O
AU - Makhmudov, R R
AU - Shipilovskikh, D A
AU - Shadrin, V M
AU - Pulina, N A
AU - Shipilovskikh, Sergei A
PY - 2022
DA - 2022/10/01
PB - Pleiades Publishing
SP - 1899-1905
IS - 10
VL - 92
SN - 1070-3632
SN - 1608-3350
ER -
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@article{2022_Gorbunova,
author = {I A Gorbunova and Yu O Sharavyeva and R R Makhmudov and D A Shipilovskikh and V M Shadrin and N A Pulina and Sergei A Shipilovskikh},
title = {Synthesis and Antinociceptive Activity of Substituted 2-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thiophene-2-ylamino)-4-oxobut-2-enoates},
journal = {Russian Journal of General Chemistry},
year = {2022},
volume = {92},
publisher = {Pleiades Publishing},
month = {oct},
url = {https://doi.org/10.1134/s1070363222100048},
number = {10},
pages = {1899--1905},
doi = {10.1134/s1070363222100048}
}
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MLA
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Gorbunova, I. A., et al. “Synthesis and Antinociceptive Activity of Substituted 2-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thiophene-2-ylamino)-4-oxobut-2-enoates.” Russian Journal of General Chemistry, vol. 92, no. 10, Oct. 2022, pp. 1899-1905. https://doi.org/10.1134/s1070363222100048.
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