Synthesis and Antimicrobial Evaluation of (E)-1-(2,4-Dichlorophenyl)-4-{3-methoxy-4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]benzylidene}-3-methyl-1H-pyrazol-5(4H)-one Derivatives

A series of novel pyrazolone-triazole compounds based on (E)-1-(2,4-dichlorophenyl)-4-[3-methoxy-4-(prop-2-yn-1-yloxy)benzylidene]-3-methyl-1H-pyrazol-5(4H)-one was synthesized the click chemistry methodology. Antibacterial and antifungal properties of the new compounds were tested. While seven compounds demonstrated antimicrobial activity against a range of bacterial strains, including Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Streptococcus pyogenes it was comparable to the drug ampicillin whereas one compound exhibited excellent antifungal activity in terms of its standard drug griseofulvin against Candida albicans. Rest of the compounds showed good antifungal activity against Candida albicans when compared to griseofulvin. The newly synthesized 1,2,3-triazoles showed good antibacterial activity and can be used as precursors of drug molecules in the future.