Design, Synthesis of Naphthyridine-Integrated Pyranopolyheterocycle Derivatives and Their Biological Activities

This study efforts on the synthesis of 1,5-naphthyridine derivatives and their biological activities. The structural characterization of the newly synthesized compounds was determined employing spectral data, including IR, NMR (1H and 13C), mass spectrometry, and elemental analysis. The SAR investigation, specifically with methoxy-substituted derivatives, exhibited notable antioxidant activity, nitro-substituted derivatives had discriminative anticancer activity against all cell lines, and chloro-substituted compounds had promising anti-tubercular activity. This study demonstrates that scaffold structures and variations of moieties can influence biological activity. Consequently, pyrano[2,3-b]pyridine-6-cabonitrile series represent acceptable drug candidates for further in vivo drug development, as they represent drug candidates for cancer and tuberculosis.